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Query: BCL2L1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BCL2L1 0 0.026

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BCL2L1 Ubiquitylation K87 0.026 _EVIPMAAVK(gl)QALR_

Background Information for BCL2L1:


Pubmed-BCL2L1 »
Uniprot-BCL2L1 »
Biogrid-BCL2L1 »
ProteomicsDB-BCL2L1 »

Tumorportal-BCL2L1 »
COSMIC-BCL2L1 »
GenomeRNAi-BCL2L1 »
Genecards-BCL2L1


Protein-protein Interactions for BCL2L1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAX Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPH1 Cat. description Hein, Mann, Cell 2015


Protein Domains in BCL2L1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Blc2_fam IPR026298 0.14
Category members Bcl2-like IPR002475 0.05


Protein complexes (CORUM database) featuring BCL2L1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5749 MRIT complex Database 0


Categories featuring BCL2L1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members Pathway Pathway_934 PID_PI3KCI_AKT_PATHWAY 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0051881 regulation of mitochondrial membrane potential Database 1.57
Category members Pathway Pathway_1023 PID_NFAT_3PATHWAY 0 1.46
Category members GO Category GO:0030672 synaptic vesicle membrane Database 1.16
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members Pathway Pathway_1043 REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 0 0.78
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members Pathway Pathway_754 SA_PROGRAMMED_CELL_DEATH 0 0.61
Category members Pathway Pathway_651 BIOCARTA_RAS_PATHWAY 0 0.61
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_1203 REACTOME_INFLAMMASOMES 0 0.5
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members Pathway Pathway_420 KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 0 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0046902 regulation of mitochondrial membrane permeability Database 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0007093 mitotic cell cycle checkpoint Database 0.27
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0051402 neuron apoptotic process Database 0.25
Category members Pathway Pathway_964 BIOCARTA_CHEMICAL_PATHWAY 0 0.24
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members GO Category GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Database 0.21
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0001836 release of cytochrome c from mitochondria Database 0.18
Category members Pathway Pathway_165 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 0 0.18
Category members GO Category GO:0000910 cytokinesis Database 0.15
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members Pathway Pathway_447 KEGG_JAK_STAT_SIGNALING_PATHWAY 0 0.13
Category members Pathway Pathway_418 PID_ATF2_PATHWAY 0 0.08
Category members GO Category GO:0009314 response to radiation Database 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0008637 apoptotic mitochondrial changes Database 0.01
Category members GO Category GO:0071312 cellular response to alkaloid Database 0.01
Category members Pathway Pathway_1012 BIOCARTA_MITOCHONDRIA_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_250 BIOCARTA_BAD_PATHWAY 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_419 PID_IL4_2PATHWAY 0 0
Category members Pathway Pathway_550 PID_IL3_PATHWAY 0 0
Category members Pathway Pathway_567 PID_IL2_STAT5_PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_585 PID_IL2_PI3K_PATHWAY 0 0
Category members Pathway Pathway_591 BIOCARTA_IL2RB_PATHWAY 0 0
Category members Pathway Pathway_652 PID_IL6_7_PATHWAY 0 0
Category members Pathway Pathway_703 PID_EPO_PATHWAY 0 0
Category members Pathway Pathway_986 PID_CD40_PATHWAY 0 0
Category members Pathway Pathway_990 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS 0 0
Category members GO Category GO:0001541 ovarian follicle development Database 0
Category members GO Category GO:0007281 germ cell development Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0008584 male gonad development Database 0
Category members GO Category GO:0009566 fertilization Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0010507 negative regulation of autophagy Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0031966 mitochondrial membrane Database 0
Category members GO Category GO:0034097 response to cytokine Database 0
Category members GO Category GO:0040007 growth Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0051434 BH3 domain binding Database 0
Category members GO Category GO:0060154 cellular process regulating host cell cycle in response to virus Database 0
Category members GO Category GO:0071230 cellular response to amino acid stimulus Database 0


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