bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: ERCC6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ERCC6 4 18.353 -1.310 2.800 0.074 0.258
ERCC6 4 18.353 -1.310 2.800 5.118 1.227 2.135
ERCC6 4 18.353 0.480 0.030 0.074 0.258
ERCC6 4 18.353 0.480 0.030 5.118 1.227 2.135

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ERCC6 Ubiquitylation K1360 2.898 _CQDGIMKK(gl)_
ERCC6 Ubiquitylation K774 0.041 1.536 _LTDEQHK(gl)VYQNFVDSK_
ERCC6 Ubiquitylation K1457 0.602 1.210 _EILQEFESK(gl)LSASQSCVFR_
ERCC6 Phosphorylation S1146 1.367 0.961 _TSMPSGDES(ph)IDEK_
ERCC6 Phosphorylation S1142 0.830 0.891 _TSMPS(ph)GDESIDEK_
ERCC6 Phosphorylation T1347 0.180 0.745 _NSNFSVQHPSST(ph)SPTEK_
ERCC6 Phosphorylation S1346 0.052 0.548 _NSNFSVQHPSS(ph)TSPTEK_
ERCC6 Phosphorylation S1068 0.742 0.512 _KFPASNISVNDATS(ph)SEEKSEAK_
ERCC6 Ubiquitylation K729 1.490 0.510 _TAYK(gl)CACVLR_
ERCC6 Phosphorylation S1345 0.486 0.469 _NSNFSVQHPS(ph)STSPTEK_
ERCC6 Phosphorylation S158 0.039 0.466 _IIEQLS(ph)PQAATSR_
ERCC6 Ubiquitylation K1295 0.149 0.443 _VAQDALK(gl)ALR_
ERCC6 Phosphorylation S1379 0.589 0.418 _AEDADS(ph)SSGPLASSSLLAK_
ERCC6 Phosphorylation S1348 0.238 0.374 _NSNFSVQHPSSTS(ph)PTEK_
ERCC6 Ubiquitylation K1328 -0.793 0.232 _GISGAPAGKK(gl)_
ERCC6 Ubiquitylation K1327 -0.793 0.156 _GISGAPAGK(gl)K_
ERCC6 Ubiquitylation K663 -0.597 0.145 _NPNAAVTLACK(gl)QFR_
ERCC6 Ubiquitylation K759 -0.019 _MSLSLPDK(gl)NEQVLFCR_
ERCC6 Ubiquitylation K783 0.262 -0.019 _VYQNFVDSK(gl)EVYR_
ERCC6 Ubiquitylation K1156 0.818 -0.034 _LGLSYK(gl)R_
ERCC6 Ubiquitylation K345 0.454 -0.211 _ALQFQGK(gl)VGLPK_
ERCC6 Ubiquitylation K1487 -0.363 -0.266 _TSGGEGIWK(gl)LKPEYC_
ERCC6 Ubiquitylation K1392 -0.822 -0.293 _AEDADSSSGPLASSSLLAK(gl)MR_
ERCC6 Phosphorylation S212 -0.295 _IELDHAS(ph)LEEDAEPGPSSLGSMLMPVQETAWEELIR_
ERCC6 Ubiquitylation K955 -0.048 -0.623 _K(gl)QVTVYR_
ERCC6 Ubiquitylation K1363 -0.116 -0.707 _EGK(gl)DNVPEHFSGR_
ERCC6 Ubiquitylation K255 0.184 -1.007 _TGQMTPFGTQIPQK(gl)QEK_
ERCC6 Ubiquitylation K258 0.830 -1.007 _TGQMTPFGTQIPQKQEK(gl)_
ERCC6 Phosphorylation T303 -1.105 _KAPAPVT(ph)PPAPVQNK_
ERCC6 Ubiquitylation K606 0.305 _VAILHETGSYTHK(gl)K_
ERCC6 Ubiquitylation K607 0.278 _VAILHETGSYTHKK(gl)_
ERCC6 Ubiquitylation K1352 -1.415 _NSNFSVQHPSSTSPTEK(gl)CQDGIMK_
ERCC6 Ubiquitylation K1359 0.923 _CQDGIMK(gl)K_

Background Information for ERCC6:


Pubmed-ERCC6 »
Uniprot-ERCC6 »
Biogrid-ERCC6 »
ProteomicsDB-ERCC6 »

Tumorportal-ERCC6 »
COSMIC-ERCC6 »
GenomeRNAi-ERCC6 »
Genecards-ERCC6


Protein-protein Interactions for ERCC6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAX Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2AP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait MPHOSPH8 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NAA50 Cat. description Hein, Mann, Cell 2015
Category members IP bait NOP56 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015


Protein Domains in ERCC6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SNF2_N IPR000330 3.38
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48


Protein complexes (CORUM database) featuring ERCC6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ERCC6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_351 REACTOME_RNA_POL_I_TRANSCRIPTION 0 8.31
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_350 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION 0 7.97
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006283 transcription-coupled nucleotide-excision repair Database 6.58
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members Pathway Pathway_336 REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 0 4.6
Category members Pathway Pathway_378 REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX 0 3.95
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_346 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION 0 3.42
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0008094 DNA-dependent ATPase activity Database 2.31
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0032786 positive regulation of DNA-dependent transcription, elongation Database 1.27
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members Disease phenotype COFS_syndrome COFS syndrome Database 0.98
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members Disease phenotype UV-sensitive_syndrome UV-sensitive syndrome Database 0.82
Category members GO Category GO:0009411 response to UV Database 0.79
Category members Disease phenotype Cockayne_syndrome_type_2 Cockayne syndrome type 2 Database 0.54
Category members GO Category GO:0010332 response to gamma radiation Database 0.52
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0010224 response to UV-B Database 0.44
Category members Disease phenotype Cockayne_syndrome_type_3 Cockayne syndrome type 3 Database 0.33
Category members GO Category GO:0032784 regulation of DNA-dependent transcription, elongation Database 0.33
Category members GO Category GO:0010165 response to X-ray Database 0.32
Category members Disease phenotype Cockayne_syndrome_type_1 Cockayne syndrome type 1 Database 0.29
Category members GO Category GO:0006290 pyrimidine dimer repair Database 0.25
Category members GO Category GO:0000303 response to superoxide Database 0.23
Category members GO Category GO:0007256 activation of JNKK activity Database 0.1
Category members GO Category GO:0007257 activation of JUN kinase activity Database 0.08
Category members GO Category GO:0006284 base-excision repair Database 0.04
Category members GO Category GO:0035264 multicellular organism growth Database 0.04
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0008023 transcription elongation factor complex Database 0
Category members GO Category GO:0009636 response to toxic substance Database 0
Category members GO Category GO:0045494 photoreceptor cell maintenance Database 0


.

© Copyright Svejstrup Laboratory 2015