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Query: KSR1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
KSR1 0 0.600 0.100 0.600

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
KSR1 Phosphorylation S334 0.052 _FDLSHGS(ph)PQMVR_
KSR1 Phosphorylation S406 -0.052 -0.067 _RTES(ph)VPSDINNPVDR_
KSR1 Phosphorylation S569 -0.413 -0.383 _ADVLEAHEAEAEEPEAGKS(ph)EAEDDEDEVDDLPSSR_

Background Information for KSR1:


Pubmed-KSR1 »
Uniprot-KSR1 »
Biogrid-KSR1 »
ProteomicsDB-KSR1 »

Tumorportal-KSR1 »
COSMIC-KSR1 »
GenomeRNAi-KSR1 »
Genecards-KSR1


Protein-protein Interactions for KSR1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MAP2K1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRMT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SKAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in KSR1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PE/DAG-bd IPR002219 0.63
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring KSR1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5877 MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex Database 0.31
Category members Corum 5920 KSR1-RAF1-MEK complex Database 0
Category members Corum 5921 KSR1-BRAF-MEK complex Database 0


Categories featuring KSR1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0043410 positive regulation of MAPK cascade Database 0.06
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_734 PID_CERAMIDE_PATHWAY 0 0
Category members GO Category GO:0005078 MAP-kinase scaffold activity Database 0
Category members GO Category GO:0007265 Ras protein signal transduction Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0031434 mitogen-activated protein kinase kinase binding Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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