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Query: EIF2AK2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF2AK2 0 0.463 -1.060 1.180 -0.657 -0.502 0.213 -0.027

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF2AK2 Phosphorylation S83 0.256 _KAVS(ph)PLLLTTTNSSEGLSMGNYIGLINR_

Background Information for EIF2AK2:


Pubmed-EIF2AK2 »
Uniprot-EIF2AK2 »
Biogrid-EIF2AK2 »
ProteomicsDB-EIF2AK2 »

Tumorportal-EIF2AK2 »
COSMIC-EIF2AK2 »
GenomeRNAi-EIF2AK2 »
Genecards-EIF2AK2


Protein-protein Interactions for EIF2AK2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDCA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait ELMSAN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF18B Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SCARB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CYP1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPX7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IQCF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MECP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF2AK2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members dsRNA-bd_dom IPR014720 0.23
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring EIF2AK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring EIF2AK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0019058 viral life cycle Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_689 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 0 3.51
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members Pathway Pathway_628 BIOCARTA_GSK3_PATHWAY 0 0.6
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0017148 negative regulation of translation Database 0.34
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members Pathway Pathway_1174 BIOCARTA_EIF2_PATHWAY 0 0.22
Category members Pathway Pathway_1050 BIOCARTA_RNA_PATHWAY 0 0.21
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity Database 0.17
Category members GO Category GO:0000186 activation of MAPKK activity Database 0.16
Category members GO Category GO:0003725 double-stranded RNA binding Database 0.1
Category members GO Category GO:0035455 response to interferon-alpha Database 0.08
Category members GO Category GO:0051607 defense response to virus Database 0.07
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0001819 positive regulation of cytokine production Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1096 BIOCARTA_RANKL_PATHWAY 0 0
Category members Pathway Pathway_593 PID_TCPTP_PATHWAY 0 0
Category members Pathway Pathway_734 PID_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_937 BIOCARTA_TOLL_PATHWAY 0 0
Category members GO Category GO:0004715 non-membrane spanning protein tyrosine kinase activity Database 0
Category members GO Category GO:0006926 virus-infected cell apoptotic process Database 0
Category members GO Category GO:0008601 protein phosphatase type 2A regulator activity Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0019054 modulation by virus of host process Database 0
Category members GO Category GO:0032722 positive regulation of chemokine production Database 0
Category members GO Category GO:0032874 positive regulation of stress-activated MAPK cascade Database 0
Category members GO Category GO:0033689 negative regulation of osteoblast proliferation Database 0
Category members GO Category GO:0045071 negative regulation of viral genome replication Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0


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