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negative regulation of viral genome replication
(GO:0045071)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
W

Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
SRPK1 2 -2.020 3.440
SRPK1 2 -2.020 3.440 -0.227 0.204
SRPK1 2 -2.020 3.440 1.541 -0.249 -0.327
SRPK3 1 -0.520 0.710 1.541 -0.249 -0.327
ILF3 1 -2.400 4.920
ILF3 1 -2.400 4.920 -3.271 -0.998 -0.391 -0.709 -0.019
ILF3 1 -2.400 4.920 -0.465 -5.193 -2.940 -2.419
RNASEL 1 -0.830 1.400 1.079 -0.385 0.549 0.456
EIF2AK2 0 -1.060 1.180 -0.657 -0.502 0.213 -0.027
MAVS 0 1.610 -0.380 -1.056 -0.630
ZC3HAV1 0 0.080 -0.160 -0.228 -0.608 -0.294 -0.298 0.086
ZC3HAV1 0 0.080 -0.160
PROX1 0 0.800 -0.550
APOBEC3F 0 -0.400 0.970 -0.141 0.306 1.390 0.929
SRPK2 0 -0.090 0.510 -0.634
TNIP1 0 1.510 -0.910
TNIP1 0 1.510 -0.910
IFI16 0 0.400 -0.680 0.620 0.590
IFITM1 0 0.560 -0.530
IFITM1 0 1.200 -0.770
PLSCR1 0 -0.520 0.570
APOBEC3C 0 -0.880 1.220 -0.141 0.306 1.390 0.929

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
APOBEC3C Ubiquitylation K197 0.530 _GLK(gl)TNFR_
APOBEC3F Ubiquitylation K197 0.530 _GLK(gl)TNFR_
EIF2AK2 Phosphorylation S83 0.256 _KAVS(ph)PLLLTTTNSSEGLSMGNYIGLINR_
IFITM1 Ubiquitylation K3 -0.716 -1.338 _M(ox)HK(gl)EEHEVAVLGPPPSTILPR_
ILF3 Phosphorylation S62 -0.267 -0.683 _GSSEQAES(ph)DNMDVPPEDDSK_
ILF3 Ubiquitylation K100 0.868 0.952 _VGLVAK(gl)GLLLK_
ILF3 Ubiquitylation K119 0.194 _EK(gl)PTTALLDK_
ILF3 Ubiquitylation K202 0.668 0.564 _QK(gl)CLAALASLR_
ILF3 Phosphorylation S382 0.107 0.115 _RPM(ox)EEDGEEKS(ph)PSK_
ILF3 Phosphorylation S384 0.054 _RPM(ox)EEDGEEKS(ph)PSK_
ILF3 Ubiquitylation K454 1.019 _TAK(gl)LHVAVK_
ILF3 Phosphorylation S482 -1.214 -1.233 _GEDS(ph)AEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVK_
ILF3 Phosphorylation S482 -1.655 -1.471 _GEDS(ph)AEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAEQGPILTK_
ILF3 Phosphorylation T486 -1.747 -6.485 _DSSKGEDSAEET(ph)EAKPAVVAPAPVVEAVSTPSAAFPSDATAENVK_
ILF3 Phosphorylation T486 -1.655 -1.310 _GEDS(ph)AEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAEQGPILTK_
ILF3 Phosphorylation T592 -0.375 -0.375 _LFPDT(ph)PLALDANK_
ILF3 Ubiquitylation K604 -0.285 _LFPDTPLALDANK(gl)K_
ILF3 Ubiquitylation K605 -0.285 _LFPDTPLALDANK(gl)K_
ILF3 Phosphorylation S812 0.288 0.380 _FNYSGS(ph)GGR_
MAVS Phosphorylation S152 0.146 -0.466 _EKEPSYPMPVQETQAPES(ph)PGENSEQALQTLSPR_
MAVS Phosphorylation S165 -0.888 _EKEPSYPMPVQETQAPESPGENSEQALQTLS(ph)PR_
MAVS Phosphorylation S222 1.349 1.006 _GPVS(ph)PSVSFQPLAR_
MAVS Ubiquitylation K362 0.082 _AGMVPSK(gl)VPTSMVLTK_
PLSCR1 Ubiquitylation K223 -0.674 -0.495 _FTIQNEK(gl)REDVLK_
PROX1 Phosphorylation S511 0.460 0.502 _DRAS(ph)PESLDLTR_
RNASEL Phosphorylation S21 0.047 -0.107 _YIASVQGSTPS(ph)PR_
RNASEL Ubiquitylation K94 -0.527 _SVELNPTQK(gl)DLVLK_
RNASEL Ubiquitylation K106 0.667 _IAELLCK(gl)NDVTDGR_
RNASEL Ubiquitylation K776 -0.046 -0.521 _NADSEIK(gl)HSTPSPTR_
RNASEL Phosphorylation S788 0.362 -0.041 _YSLS(ph)PSK_
RNASEL Phosphorylation S796 0.553 0.575 _SYKYS(ph)PK_
RNASEL Phosphorylation S955 -0.786 0.030 _FESPATGILS(ph)PR_
RNASEL Phosphorylation S1160 -1.328 _NHETDGGS(ph)AHGDDDDDGPHFEPVVPLPDKIEVK_
RNASEL Ubiquitylation K1220 0.641 _GIGNVK(gl)ILR_
RNASEL Phosphorylation T1396 -0.510 -0.398 _ELVGPPLAETVFT(ph)PKT(ph)SPENVQDR_
RNASEL Phosphorylation T1399 -0.665 _ELVGPPLAETVFT(ph)PKT(ph)SPENVQDR_
RNASEL Phosphorylation S1400 -0.440 0.082 _ELVGPPLAETVFT(ph)PKTS(ph)PENVQDR_
RNASEL Phosphorylation S1456 0.018 0.508 _SGSSFVHQAS(ph)FK_
RNASEL Phosphorylation S1573 0.499 _CVACQNPDKPS(ph)PSTSVPAPASFK_
RNASEL Ubiquitylation K1963 -0.768 _STSGEGFQFGK(gl)K_
RNASEL Ubiquitylation K1964 -0.768 _STSGEGFQFGK(gl)K_
RNASEL Ubiquitylation K2061 0.441 0.872 _GLGNLK(gl)ILK_
RNASEL Phosphorylation S2250 1.539 -0.701 _EDALDDSVSSSSVHASPLAS(ph)SPVRK_
RNASEL Phosphorylation S2251 -0.023 _EDALDDSVSSSSVHASPLASS(ph)PVRK_
RNASEL Phosphorylation S2276 0.074 0.029 _SALS(ph)PSKSPAK_
RNASEL Phosphorylation S2280 0.065 0.135 _SALSPSKS(ph)PAK_
RNASEL Phosphorylation T2293 0.717 0.584 _LNQSGTSVGT(ph)DEESDVTQEEER_
RNASEL Ubiquitylation K2358 0.436 0.327 _GIGDIK(gl)ILQNYDNK_
RNASEL Ubiquitylation K2379 -0.664 0.332 _DQVLK(gl)LCANHR_
RNASEL Ubiquitylation K2396 -0.954 0.190 _ITPDMTLQNMK(gl)GTER_
RNASEL Phosphorylation S2454 0.335 0.393 _DSLIT(ph)PHVS(ph)R_
RNASEL Phosphorylation S2510 -0.171 0.107 _AVVS(ph)PPKFVFGSESVK_
RNASEL Ubiquitylation K2592 -0.298 _NSDIEQSSDSK(gl)VK_
RNASEL Ubiquitylation K2594 -0.298 _NSDIEQSSDSK(gl)VK_
RNASEL Phosphorylation T2613 -0.775 -0.709 _NLFASFPTEESSINYTFKT(ph)PEK_
RNASEL Ubiquitylation K2650 0.439 _ALATK(gl)LK_
RNASEL Phosphorylation Y2666 0.598 _NRPDY(ph)VSEEEEDDEDFETAVKK_
RNASEL Phosphorylation S2668 0.584 0.573 _NRPDYVS(ph)EEEEDDEDFETAVK_
RNASEL Phosphorylation S2804 0.874 _SIS(ph)SPSVSSETM(ox)DKPVDLSTR_
RNASEL Phosphorylation S2805 -0.018 0.448 _SISS(ph)PSVSSETMDKPVDLSTR_
RNASEL Phosphorylation S2900 -0.395 -0.513 _VGEDEDGS(ph)DEEVVHNEDIHFEPIVSLPEVEVK_
RNASEL Ubiquitylation K2935 -1.498 0.007 _SGEEDEEILFK(gl)ER_
RNASEL Phosphorylation S3207 0.368 0.527 _IESFGS(ph)PK_
SRPK1 Phosphorylation S67 -1.128 -1.153 _GSAPHSESDLPEQEEEILGS(ph)DDDEQEDPNDYCK_
SRPK1 Ubiquitylation K579 0.354 _K(gl)LIVAGK_
SRPK1 Ubiquitylation K585 0.939 _KLIVAGK(gl)YSK_
SRPK2 Phosphorylation S483 -1.638 _IPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEES(ph)SPSHDR_
SRPK2 Phosphorylation S496 0.096 _TVSAS(ph)STGDLPK_
SRPK2 Phosphorylation S497 -0.015 -0.154 _TVSASS(ph)TGDLPK_
SRPK2 Ubiquitylation K618 0.453 _HFALSGK(gl)YSR_
TNIP1 Phosphorylation S77 -0.684 _DNELLPPPS(ph)PSLGSFDPLAELTGK_
TNIP1 Ubiquitylation K371 -0.625 _LLLAK(gl)SK_
TNIP1 Ubiquitylation K373 -0.353 _LLLAKSK(gl)_
TNIP1 Phosphorylation S403 0.455 0.424 _YLQDQLS(ph)PLTR_
ZC3HAV1 Phosphorylation S275 0.409 0.461 _SCTPS(ph)PDQISHR_
ZC3HAV1 Phosphorylation S284 0.511 0.451 _AS(ph)LEDAPVDDLTR_
ZC3HAV1 Phosphorylation S302 1.342 _KFTYLGS(ph)QDR_
ZC3HAV1 Ubiquitylation K374 -1.233 _RK(gl)TVFSPTLPAAR_
ZC3HAV1 Phosphorylation S378 -0.240 0.105 _TVFS(ph)PTLPAAR_
ZC3HAV1 Phosphorylation S386 -0.801 0.173 _S(ph)SLGSLQTPEAVTTR_
ZC3HAV1 Phosphorylation S387 -0.905 0.173 _SS(ph)LGSLQTPEAVTTR_
ZC3HAV1 Ubiquitylation K448 0.090 _SLNYK(gl)STSSGHR_


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