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Query: SRPK1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SRPK1 2 3.040 -2.020 3.440
SRPK1 2 3.040 -2.020 3.440 -0.227 0.204
SRPK1 2 3.040 -2.020 3.440 1.541 -0.249 -0.327

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SRPK1 Phosphorylation S67 -1.128 -1.153 _GSAPHSESDLPEQEEEILGS(ph)DDDEQEDPNDYCK_
SRPK1 Ubiquitylation K579 0.354 _K(gl)LIVAGK_
SRPK1 Ubiquitylation K585 0.939 _KLIVAGK(gl)YSK_

Background Information for SRPK1:


Pubmed-SRPK1 »
Uniprot-SRPK1 »
Biogrid-SRPK1 »
ProteomicsDB-SRPK1 »

Tumorportal-SRPK1 »
COSMIC-SRPK1 »
GenomeRNAi-SRPK1 »
Genecards-SRPK1


Protein-protein Interactions for SRPK1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait GTF3C4 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCAPH Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARL6IP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DGCR8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DHX8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LUC7L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LUC7L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPS14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait U2AF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait U2AF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZRSR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SRPK1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring SRPK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3055 Nop56p-associated pre-rRNA complex Database INF
Category members Corum 924 Toposome Database 0.88
Category members Corum 1332 Large Drosha complex Database 0.08


Categories featuring SRPK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0045070 positive regulation of viral genome replication Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0035092 sperm chromatin condensation Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0045071 negative regulation of viral genome replication Database 0
Category members GO Category GO:0048024 regulation of mRNA splicing, via spliceosome Database 0
Category members GO Category GO:0050684 regulation of mRNA processing Database 0


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