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Query: APP

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
APP 0 -2.773 0.100 -0.260 0.285

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
APP Ubiquitylation K751 -1.778 -1.280 _HLSK(gl)M(ox)QQNGYENPTYK_

Background Information for APP:


Pubmed-APP »
Uniprot-APP »
Biogrid-APP »
ProteomicsDB-APP »

Tumorportal-APP »
COSMIC-APP »
GenomeRNAi-APP »
Genecards-APP


Protein-protein Interactions for APP
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZFC3H1 Cat. description Hein, Mann, Cell 2015
Category members IP bait APBA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APBB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APBB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APBB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLEC12A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait F11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HS2ST1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL20RB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait QTRT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM30A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM30B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in APP
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Amyloid_glyco_extra IPR008154 0.26
Category members Amyloid_glyco IPR008155 0.26
Category members Amyloid_glyco_Cu-bd IPR011178 0.26
Category members Amyloid_glyco_heparin-bd IPR015849 0.26
Category members APP_amyloid_C IPR019543 0.26
Category members Amyloid_glyco_E2_domain IPR024329 0.26
Category members Prot_inh_Kunz-m IPR002223 0.05


Protein complexes (CORUM database) featuring APP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 143 APP-FE65-LRP complex Database 0


Categories featuring APP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_1105 REACTOME_GPCR_LIGAND_BINDING 0 2.35
Category members Pathway Pathway_1182 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 0 1.69
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0004867 serine-type endopeptidase inhibitor activity Database 1.42
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0043198 dendritic shaft Database 0.93
Category members GO Category GO:0043197 dendritic spine Database 0.86
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_1043 REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 0 0.78
Category members Pathway Pathway_920 REACTOME_AMYLOIDS 0 0.68
Category members Pathway Pathway_1186 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS 0 0.54
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_1203 REACTOME_INFLAMMASOMES 0 0.5
Category members Pathway Pathway_263 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 0 0.49
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0040014 regulation of multicellular organism growth Database 0.35
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0008201 heparin binding Database 0.27
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0046914 transition metal ion binding Database 0.26
Category members GO Category GO:0051402 neuron apoptotic process Database 0.25
Category members GO Category GO:0030424 axon Database 0.23
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members GO Category GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Database 0.21
Category members Pathway Pathway_1204 REACTOME_THE_NLRP3_INFLAMMASOME 0 0.2
Category members Pathway Pathway_1141 BIOCARTA_P35ALZHEIMERS_PATHWAY 0 0.19
Category members GO Category GO:0033130 acetylcholine receptor binding Database 0.19
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0005905 coated pit Database 0.17
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_797 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 0 0.12
Category members GO Category GO:0031175 neuron projection development Database 0.12
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_813 REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 0 0.11
Category members GO Category GO:0006378 mRNA polyadenylation Database 0.1
Category members GO Category GO:0008203 cholesterol metabolic process Database 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0010971 positive regulation of G2/M transition of mitotic cell cycle Database 0.07
Category members Pathway Pathway_484 REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 0 0.06
Category members Pathway Pathway_953 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI 0 0.06
Category members GO Category GO:0045202 synapse Database 0.06
Category members GO Category GO:0016504 peptidase activator activity Database 0.06
Category members Pathway Pathway_814 REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0001967 suckling behavior Database 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0043393 regulation of protein binding Database 0.04
Category members GO Category GO:0045665 negative regulation of neuron differentiation Database 0.04
Category members GO Category GO:0045931 positive regulation of mitotic cell cycle Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_457 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING 0 0.04
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members Pathway Pathway_834 REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 0 0.04
Category members Disease phenotype Early-onset_autosomal_dominant_Alzheimer_disease Early-onset autosomal dominant Alzheimer disease Database 0.04
Category members GO Category GO:0070851 growth factor receptor binding Database 0.04
Category members Pathway Pathway_1241 BIOCARTA_PLATELETAPP_PATHWAY 0 0.04
Category members Pathway Pathway_486 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 0 0.04
Category members GO Category GO:0006878 cellular copper ion homeostasis Database 0.04
Category members GO Category GO:0035253 ciliary rootlet Database 0.03
Category members GO Category GO:0050885 neuromuscular process controlling balance Database 0.02
Category members GO Category GO:0051425 PTB domain binding Database 0.02
Category members GO Category GO:0007617 mating behavior Database 0.01
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_487 REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 0 0
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_718 PID_GLYPICAN_1PATHWAY 0 0
Category members Pathway Pathway_954 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION 0 0
Category members Pathway Pathway_958 REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX 0 0
Category members Disease phenotype ALZHEIMER_DISEASE ALZHEIMER DISEASE Database 0
Category members GO Category GO:0000085 mitotic G2 phase Database 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0006417 regulation of translation Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007176 regulation of epidermal growth factor-activated receptor activity Database 0
Category members GO Category GO:0007626 locomotory behavior Database 0
Category members GO Category GO:0008088 axon cargo transport Database 0
Category members GO Category GO:0008344 adult locomotory behavior Database 0
Category members GO Category GO:0008542 visual learning Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0010952 positive regulation of peptidase activity Database 0
Category members GO Category GO:0016199 axon midline choice point recognition Database 0
Category members GO Category GO:0016322 neuron remodeling Database 0
Category members GO Category GO:0016358 dendrite development Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0031093 platelet alpha granule lumen Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0031594 neuromuscular junction Database 0
Category members GO Category GO:0035235 ionotropic glutamate receptor signaling pathway Database 0
Category members GO Category GO:0045177 apical part of cell Database 0
Category members GO Category GO:0048669 collateral sprouting in absence of injury Database 0
Category members GO Category GO:0050803 regulation of synapse structure and activity Database 0
Category members GO Category GO:0051124 synaptic growth at neuromuscular junction Database 0
Category members GO Category GO:0051233 spindle midzone Database 0
Category members GO Category GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis Database 0


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