Results for the Category
REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING
(Pathway_457)
| RNAi screen result | RNAPII IP (MG132) | CSB IP | CSB IP (MG132) | Chrom. | Chrom. (MG132) | Ubi /Phospo | Ubi /Phospho (MG132) |
| W | |||||||
| Gene name | MGoogle Score | RNAi high | RNAi low | RNAPII-IP (MG132) | CSB-IP | CSB-IP (MG132) | Chrom. | Chrom. (MG132) |
|---|---|---|---|---|---|---|---|---|
| HMGB1 | 2 | -1.590 | 3.400 | 2.856 | -1.899 | 0.030 | -0.792 | |
| PRKCSH | 1 | 0.550 | 0.060 | 0.459 | 0.419 | |||
| CAPZA2 | 1 | -1.410 | 3.640 | -0.055 | -0.006 | 0.467 | -0.183 | |
| MAPK3 | 0 | |||||||
| CAPZA1 | 0 | 0.560 | -0.680 | |||||
| CAPZA1 | 0 | 0.560 | -0.680 | -0.049 | -0.077 | 0.058 | 0.155 | -0.264 |
| LGALS3 | 0 | 0.430 | -0.510 | -0.143 | -1.425 | |||
| APP | 0 | 0.100 | -0.260 | 0.285 | ||||
| DDOST | 0 | 1.280 | -0.390 | 0.151 | -0.462 | 0.509 | 0.295 |
| Gene name | PTM type | PTM site | UV | UV (MG132) | Sequence |
|---|---|---|---|---|---|
| APP | Ubiquitylation | K751 | -1.778 | -1.280 | _HLSK(gl)M(ox)QQNGYENPTYK_ |
| CAPZA1 | Phosphorylation | S9 | 0.754 | 0.930 | _(ac)ADFDDRVS(ph)DEEKVR_ |
| CAPZA1 | Ubiquitylation | K118 | -1.483 | -1.231 | _EASDPQPEEADGGLK(gl)SWR_ |
| CAPZA2 | Phosphorylation | S9 | 0.432 | 0.806 | _(ac)ADLEEQLS(ph)DEEKVR_ |
| CAPZA2 | Ubiquitylation | K147 | -0.399 | _EHYPNGVCTVYGKK(gl)_ | |
| CAPZA2 | Ubiquitylation | K268 | 0.156 | 0.188 | _TK(gl)IDWNK_ |
| CAPZA2 | Ubiquitylation | K278 | -0.071 | -0.333 | _ILSYK(gl)IGK_ |
| CAPZA2 | Ubiquitylation | K281 | -0.195 | -0.420 | _IGK(gl)EMQNA_ |
| DDOST | Ubiquitylation | K189 | -0.337 | _APTIVGK(gl)SSLNPILFR_ | |
| HMGB1 | Ubiquitylation | K50 | 0.651 | _WK(gl)TMSAK_ | |
| HMGB1 | Ubiquitylation | K59 | 1.001 | 0.009 | _GK(gl)FEDMAK_ |
| HMGB1 | Ubiquitylation | K114 | 0.314 | _IK(gl)GEHPGLSIGDVAK_ | |
| HMGB1 | Ubiquitylation | K127 | 0.018 | _IKGEHPGLSIGDVAK(gl)K_ | |
| HMGB1 | Ubiquitylation | K128 | -0.407 | _K(gl)LGEMWNNTAADDKQPYEK_ | |
| HMGB1 | Ubiquitylation | K157 | 0.850 | _YEK(gl)DIAAYR_ | |
| MAPK3 | Phosphorylation | Y204 | -0.807 | -2.487 | _IADPEHDHTGFLTEY(ph)VATR_ |
| MAPK3 | Ubiquitylation | K289 | -0.608 | _NYLQSLPSKTK(gl)_ | |
| PRKCSH | Ubiquitylation | K383 | 1.564 | 0.883 | _NK(gl)FEEAER_ |
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