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Query: HMGB1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HMGB1 2 4.910 -1.590 3.400 2.856 -1.899 0.030 -0.792

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HMGB1 Ubiquitylation K114 0.314 _IK(gl)GEHPGLSIGDVAK_
HMGB1 Ubiquitylation K59 1.001 0.009 _GK(gl)FEDMAK_
HMGB1 Ubiquitylation K50 0.651 _WK(gl)TMSAK_
HMGB1 Ubiquitylation K127 0.018 _IKGEHPGLSIGDVAK(gl)K_
HMGB1 Ubiquitylation K128 -0.407 _K(gl)LGEMWNNTAADDKQPYEK_
HMGB1 Ubiquitylation K157 0.850 _YEK(gl)DIAAYR_

Background Information for HMGB1:


Pubmed-HMGB1 »
Uniprot-HMGB1 »
Biogrid-HMGB1 »
ProteomicsDB-HMGB1 »

Tumorportal-HMGB1 »
COSMIC-HMGB1 »
GenomeRNAi-HMGB1 »
Genecards-HMGB1


Protein-protein Interactions for HMGB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AIFM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NRIP3 Cat. description Hein, Mann, Cell 2015


Protein Domains in HMGB1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HMG_box_dom IPR009071 0.31


Protein complexes (CORUM database) featuring HMGB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 280 HMGB1-HMGB2-HSC70-ERP60-GAPDH complex Database 1.56
Category members Corum 2719 Casein kinase II-HMG1 complex Database 0.13


Categories featuring HMGB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0006265 DNA topological change Database 1.92
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0000793 condensed chromosome Database 1.32
Category members GO Category GO:0051103 DNA ligation involved in DNA repair Database 1.31
Category members GO Category GO:0005125 cytokine activity Database 1.06
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_956 BIOCARTA_DNAFRAGMENT_PATHWAY 0 0.62
Category members GO Category GO:0006288 base-excision repair, DNA ligation Database 0.6
Category members GO Category GO:0033151 V(D)J recombination Database 0.52
Category members Pathway Pathway_955 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION 0 0.51
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members GO Category GO:0006309 apoptotic DNA fragmentation Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members Pathway Pathway_957 PID_AMB2_NEUTROPHILS_PATHWAY 0 0.2
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0009986 cell surface Database 0.17
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_797 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 0 0.12
Category members GO Category GO:0031175 neuron projection development Database 0.12
Category members Pathway Pathway_813 REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 0 0.11
Category members Pathway Pathway_484 REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 0 0.06
Category members Pathway Pathway_953 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI 0 0.06
Category members Pathway Pathway_814 REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_457 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING 0 0.04
Category members Pathway Pathway_834 REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 0 0.04
Category members GO Category GO:0002407 dendritic cell chemotaxis Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_334 KEGG_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_740 PID_INTEGRIN3_PATHWAY 0 0
Category members Pathway Pathway_850 PID_TOLL_ENDOGENOUS_PATHWAY 0 0
Category members Pathway Pathway_954 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION 0 0
Category members Pathway Pathway_958 REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX 0 0
Category members GO Category GO:0001773 myeloid dendritic cell activation Database 0
Category members GO Category GO:0002437 inflammatory response to antigenic stimulus Database 0
Category members GO Category GO:0008301 DNA binding, bending Database 0
Category members GO Category GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly Database 0
Category members GO Category GO:0042056 chemoattractant activity Database 0
Category members GO Category GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0043388 positive regulation of DNA binding Database 0
Category members GO Category GO:0050786 RAGE receptor binding Database 0
Category members GO Category GO:0050918 positive chemotaxis Database 0
Category members GO Category GO:0070491 repressing transcription factor binding Database 0


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