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Query: TRAF3

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TRAF3 0 -2.159 -1.050 1.040

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TRAF3 Ubiquitylation K369 -1.061 -2.137 _VTELESVDK(gl)SAGQVAR_

Background Information for TRAF3:


Pubmed-TRAF3 »
Uniprot-TRAF3 »
Biogrid-TRAF3 »
ProteomicsDB-TRAF3 »

Tumorportal-TRAF3 »
COSMIC-TRAF3 »
GenomeRNAi-TRAF3 »
Genecards-TRAF3


Protein-protein Interactions for TRAF3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ECH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EDA2R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LTBR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAP3K14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SHPK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNAP29 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSKS Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TRAF3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TNF_rcpt--assoc_TRAF IPR012227 0.05
Category members Znf_TRAF IPR001293 0
Category members Znf_RING IPR001841 0
Category members MATH IPR002083 0
Category members TRAF-like IPR008974 0


Protein complexes (CORUM database) featuring TRAF3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5210 TANK-TRAF2-TRAF3 complex Database 0


Categories featuring TRAF3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_608 SIG_CD40PATHWAYMAP 0 0.89
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0035666 TRIF-dependent toll-like receptor signaling pathway Database 0.29
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0034138 toll-like receptor 3 signaling pathway Database 0.28
Category members GO Category GO:0034142 toll-like receptor 4 signaling pathway Database 0.27
Category members GO Category GO:0002756 MyD88-independent toll-like receptor signaling pathway Database 0.25
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members Pathway Pathway_1005 ST_ERK1_ERK2_MAPK_PATHWAY 0 0.06
Category members Pathway Pathway_484 REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 0 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_1226 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY 0 0.05
Category members GO Category GO:0032088 negative regulation of NF-kappaB transcription factor activity Database 0.04
Category members Pathway Pathway_1045 BIOCARTA_TNFR2_PATHWAY 0 0
Category members Pathway Pathway_1049 BIOCARTA_TALL1_PATHWAY 0 0
Category members Pathway Pathway_1055 BIOCARTA_CD40_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_483 KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_612 KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_785 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING 0 0
Category members Pathway Pathway_825 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON 0 0
Category members Pathway Pathway_986 PID_CD40_PATHWAY 0 0
Category members Disease phenotype Herpetic_encephalitis Herpetic encephalitis Database 0
Category members GO Category GO:0001817 regulation of cytokine production Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0008063 Toll signaling pathway Database 0
Category members GO Category GO:0009898 cytoplasmic side of plasma membrane Database 0
Category members GO Category GO:0030162 regulation of proteolysis Database 0
Category members GO Category GO:0031996 thioesterase binding Database 0
Category members GO Category GO:0032480 negative regulation of type I interferon production Database 0
Category members GO Category GO:0032648 regulation of interferon-beta production Database 0
Category members GO Category GO:0033209 tumor necrosis factor-mediated signaling pathway Database 0
Category members GO Category GO:0035631 CD40 receptor complex Database 0
Category members GO Category GO:0050688 regulation of defense response to virus Database 0


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