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Query: IFIH1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
IFIH1 0 -1.067 1.630 -0.790

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
IFIH1 Phosphorylation S301 -1.067 _AS(ph)PEPELQLRPYQMEVAQPALEGK_

Background Information for IFIH1:


Pubmed-IFIH1 »
Uniprot-IFIH1 »
Biogrid-IFIH1 »
ProteomicsDB-IFIH1 »

Tumorportal-IFIH1 »
COSMIC-IFIH1 »
GenomeRNAi-IFIH1 »
Genecards-IFIH1


Protein-protein Interactions for IFIH1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC9 Cat. description Hein, Mann, Cell 2015
Category members IP bait G3BP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait SART1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MPZL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in IFIH1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members DEATH-like_dom IPR011029 1.15
Category members Helicase/UvrB_dom IPR006935 0.78
Category members CARD IPR001315 0.55
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members RIG-I_C-RD IPR021673 0


Protein complexes (CORUM database) featuring IFIH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring IFIH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0016925 protein sumoylation Database 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members GO Category GO:0003725 double-stranded RNA binding Database 0.1
Category members GO Category GO:0016817 hydrolase activity, acting on acid anhydrides Database 0.06
Category members Pathway Pathway_484 REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 0 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Disease phenotype Aicardi-Goutieres_Syndrome Aicardi-Goutieres Syndrome Database 0.05
Category members Pathway Pathway_1226 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY 0 0.05
Category members Pathway Pathway_1042 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 0 0
Category members Pathway Pathway_1165 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION 0 0
Category members Pathway Pathway_483 KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_785 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING 0 0
Category members Pathway Pathway_954 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION 0 0
Category members GO Category GO:0003727 single-stranded RNA binding Database 0
Category members GO Category GO:0009597 detection of virus Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0032480 negative regulation of type I interferon production Database 0
Category members GO Category GO:0032727 positive regulation of interferon-alpha production Database 0
Category members GO Category GO:0032728 positive regulation of interferon-beta production Database 0
Category members GO Category GO:0034344 regulation of type III interferon production Database 0
Category members GO Category GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus Database 0
Category members GO Category GO:0043021 ribonucleoprotein complex binding Database 0


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