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Query: WNK2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
WNK2 0 1.292 -0.660 0.130
WNK2 0 1.292 -0.660 0.130 0.546 0.639

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
WNK2 Phosphorylation S2530 0.202 -0.225 _DVDDGSGSPHS(ph)PHQLSSK_
WNK2 Phosphorylation S2509 -0.298 _KEKPELSEPSHLNGPS(ph)SDPEAAFLSR_
WNK2 Phosphorylation S2510 -0.532 -0.298 _KEKPELSEPSHLNGPSS(ph)DPEAAFLSR_
WNK2 Phosphorylation S1777 -0.593 _KRPEQQDVSS(ph)PAK_
WNK2 Phosphorylation S2503 -0.810 -0.764 _KEKPELSEPS(ph)HLNGPSSDPEAAFLSR_
WNK2 Phosphorylation S2476 -0.727 -0.899 _KEGPVAS(ph)PPFMDLEQAVLPAVIPK_
WNK2 Phosphorylation S1776 -1.152 _KRPEQQDVS(ph)SPAK_
WNK2 Phosphorylation S2527 -0.349 _DVDDGSGS(ph)PHSPHQLSSK_

Background Information for WNK2:


Pubmed-WNK2 »
Uniprot-WNK2 »
Biogrid-WNK2 »
ProteomicsDB-WNK2 »

Tumorportal-WNK2 »
COSMIC-WNK2 »
GenomeRNAi-WNK2 »
Genecards-WNK2


Protein-protein Interactions for WNK2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SPATA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSC22D4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in WNK2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase_OSR1/WNK_CCT IPR024678 0.04
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring WNK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring WNK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0070373 negative regulation of ERK1 and ERK2 cascade Database 0.1
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0


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