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Query: NF2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NF2 0 4.524 -1.080 1.470
NF2 0 4.524 -1.080 1.470 0.218 -0.073

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NF2 Phosphorylation S493 1.436 1.115 _RLS(ph)MEIEK_
NF2 Phosphorylation S13 0.833 0.924 _MSFSS(ph)LKR_
NF2 Ubiquitylation K586 0.399 -0.041 _LTLQSAK(gl)SR_

Background Information for NF2:


Pubmed-NF2 »
Uniprot-NF2 »
Biogrid-NF2 »
ProteomicsDB-NF2 »

Tumorportal-NF2 »
COSMIC-NF2 »
GenomeRNAi-NF2 »
Genecards-NF2


Protein-protein Interactions for NF2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIN7C Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait NF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC33A1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TNKS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait YAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF166 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NF2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members Ez/rad/moesin_like IPR000798 0.38
Category members FERM_N IPR018979 0.36
Category members FERM_PH-like_C IPR018980 0.35
Category members Band_41_fam IPR019750 0.33
Category members Tropomyosin IPR000533 0.08
Category members FERM_domain IPR000299 0
Category members Moesin_tail IPR008954 0
Category members ERM IPR011174 0
Category members ERM_C_dom IPR011259 0
Category members FERM_central IPR019748 0
Category members Band_41_domain IPR019749 0


Protein complexes (CORUM database) featuring NF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003779 actin binding Database 5.41
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0032154 cleavage furrow Database 2.01
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members GO Category GO:0005769 early endosome Database 1.26
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members GO Category GO:0043409 negative regulation of MAPK cascade Database 0.87
Category members GO Category GO:0030336 negative regulation of cell migration Database 0.85
Category members GO Category GO:0031527 filopodium membrane Database 0.74
Category members GO Category GO:0032587 ruffle membrane Database 0.65
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0008092 cytoskeletal protein binding Database 0.5
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0001726 ruffle Database 0.33
Category members Disease phenotype MESOTHELIOMA_MALIGNANT MESOTHELIOMA MALIGNANT Database 0.31
Category members Disease phenotype SCHWANNOMATOSIS_1 SCHWANNOMATOSIS 1 Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0014010 Schwann cell proliferation Database 0.28
Category members GO Category GO:0035330 regulation of hippo signaling Database 0.27
Category members GO Category GO:0005912 adherens junction Database 0.25
Category members Pathway Pathway_532 PID_ERBB2_ERBB3_PATHWAY 0 0.13
Category members GO Category GO:0070306 lens fiber cell differentiation Database 0.13
Category members GO Category GO:0001707 mesoderm formation Database 0.11
Category members GO Category GO:0045216 cell-cell junction organization Database 0.1
Category members GO Category GO:0042524 negative regulation of tyrosine phosphorylation of Stat5 protein Database 0.08
Category members Disease phenotype Neurofibromatosis_type_3 Neurofibromatosis type 3 Database 0.08
Category members GO Category GO:0030864 cortical actin cytoskeleton Database 0.06
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0030175 filopodium Database 0.05
Category members GO Category GO:0007398 ectoderm development Database 0.04
Category members GO Category GO:0008156 negative regulation of DNA replication Database 0.03
Category members GO Category GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein Database 0.02
Category members GO Category GO:0001953 negative regulation of cell-matrix adhesion Database 0
Category members GO Category GO:0006469 negative regulation of protein kinase activity Database 0
Category members GO Category GO:0019898 extrinsic to membrane Database 0
Category members GO Category GO:0022408 negative regulation of cell-cell adhesion Database 0
Category members GO Category GO:0042475 odontogenesis of dentin-containing tooth Database 0
Category members GO Category GO:0046426 negative regulation of JAK-STAT cascade Database 0
Category members GO Category GO:0051496 positive regulation of stress fiber assembly Database 0


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