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Query: CAV1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CAV1 0 3.418 1.150 -0.150

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CAV1 Ubiquitylation K39 0.690 1.170 _AMADELSEK(gl)QVYDAHTK_
CAV1 Ubiquitylation K5 0.591 0.963 _(ac)SGGK(gl)YVDSEGHLYTVPIR_
CAV1 Ubiquitylation K26 0.724 0.894 _EQGNIYK(gl)PNNK_
CAV1 Ubiquitylation K8 0.244 0.734 _(ac)ADELSEK(gl)QVYDAHTK_
CAV1 Phosphorylation S6 0.836 0.688 _(ac)ADELS(ph)EKQVYDAHTK_
CAV1 Phosphorylation S76 0.607 0.527 _AMADELS(ph)EK_
CAV1 Ubiquitylation K30 -0.008 0.317 _EQGNIYKPNNK(gl)AMADELSEK_
CAV1 Ubiquitylation K176 -0.259 _INLQK(gl)EI_

Background Information for CAV1:


Pubmed-CAV1 »
Uniprot-CAV1 »
Biogrid-CAV1 »
ProteomicsDB-CAV1 »

Tumorportal-CAV1 »
COSMIC-CAV1 »
GenomeRNAi-CAV1 »
Genecards-CAV1


Protein-protein Interactions for CAV1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait C1QBP Cat. description Hein, Mann, Cell 2015
Category members IP bait CD2AP Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTC Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNLL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FAM82A2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FGFR1OP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait KCNK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MBOAT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MMGT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PTPN23 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB2A Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5C Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB7A Cat. description Hein, Mann, Cell 2015
Category members IP bait SPAST Cat. description Hein, Mann, Cell 2015
Category members IP bait TAPT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMED2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMEM63B Cat. description Hein, Mann, Cell 2015
Category members IP bait TSG101 Cat. description Hein, Mann, Cell 2015
Category members IP bait VAPA Cat. description Hein, Mann, Cell 2015
Category members IP bait YIPF5 Cat. description Hein, Mann, Cell 2015
Category members IP bait AGTR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAV3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHRM3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FNDC4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR2C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPAR4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPAR6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P2RY12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC22A9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC37A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC5A8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC6A15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMPD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TACR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM184A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YIPF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CAV1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Caveolin IPR001612 0.17


Protein complexes (CORUM database) featuring CAV1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 557 TRP1-G alpha-11-IP3R3-CAV1 signaling complex Database 0.41
Category members Corum 5862 CAV1-VDAC1-ESR1 complex Database 0.11
Category members Corum 753 UTM-SGCE-DAG1-CAV1-NOS3 complex Database 0.02
Category members Corum 550 NOS3-CAV1-NOSTRIN complex Database 0
Category members Corum 5714 eNOS-CAV1 complex Database 0


Categories featuring CAV1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0005198 structural molecule activity Database 0.94
Category members GO Category GO:0043409 negative regulation of MAPK cascade Database 0.87
Category members GO Category GO:0032947 protein complex scaffold Database 0.82
Category members Pathway Pathway_995 PID_ALK1_PATHWAY 0 0.69
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members Pathway Pathway_671 PID_WNT_CANONICAL_PATHWAY 0 0.64
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members GO Category GO:0008104 protein localization Database 0.5
Category members GO Category GO:0043627 response to estrogen Database 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0016050 vesicle organization Database 0.31
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0030193 regulation of blood coagulation Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0033137 negative regulation of peptidyl-serine phosphorylation Database 0.21
Category members GO Category GO:0032507 maintenance of protein location in cell Database 0.17
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0032570 response to progesterone Database 0.1
Category members GO Category GO:0042524 negative regulation of tyrosine phosphorylation of Stat5 protein Database 0.08
Category members GO Category GO:0032091 negative regulation of protein binding Database 0.08
Category members GO Category GO:0030666 endocytic vesicle membrane Database 0.08
Category members Pathway Pathway_496 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS 0 0.07
Category members GO Category GO:0016504 peptidase activator activity Database 0.06
Category members Pathway Pathway_600 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 0 0.05
Category members GO Category GO:0015485 cholesterol binding Database 0.04
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members GO Category GO:0002931 response to ischemia Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0009267 cellular response to starvation Database 0.03
Category members GO Category GO:0033138 positive regulation of peptidyl-serine phosphorylation Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_927 REACTOME_BASIGIN_INTERACTIONS 0 0
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_301 BIOCARTA_NO1_PATHWAY 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_431 PID_VEGFR1_PATHWAY 0 0
Category members Pathway Pathway_438 REACTOME_ENOS_ACTIVATION_AND_REGULATION 0 0
Category members Pathway Pathway_490 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 0 0
Category members Pathway Pathway_531 PID_PDGFRA_PATHWAY 0 0
Category members Pathway Pathway_571 PID_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_602 PID_PTP1B_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members Disease phenotype Berardinelli-Seip_congenital_lipodystrophy Berardinelli-Seip congenital lipodystrophy Database 0
Category members Disease phenotype Diffuse_cutaneous_systemic_sclerosis Diffuse cutaneous systemic sclerosis Database 0
Category members Disease phenotype Heritable_pulmonary_arterial_hypertension Heritable pulmonary arterial hypertension Database 0
Category members Disease phenotype Limited_cutaneous_systemic_sclerosis Limited cutaneous systemic sclerosis Database 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0000165 MAPK cascade Database 0
Category members GO Category GO:0000188 inactivation of MAPK activity Database 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001570 vasculogenesis Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001937 negative regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0001960 negative regulation of cytokine-mediated signaling pathway Database 0
Category members GO Category GO:0002026 regulation of the force of heart contraction Database 0
Category members GO Category GO:0002080 acrosomal membrane Database 0
Category members GO Category GO:0003057 regulation of the force of heart contraction by chemical signal Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0005113 patched binding Database 0
Category members GO Category GO:0005811 lipid particle Database 0
Category members GO Category GO:0005901 caveola Database 0
Category members GO Category GO:0005929 cilium Database 0
Category members GO Category GO:0006641 triglyceride metabolic process Database 0
Category members GO Category GO:0006816 calcium ion transport Database 0
Category members GO Category GO:0006874 cellular calcium ion homeostasis Database 0
Category members GO Category GO:0006940 regulation of smooth muscle contraction Database 0
Category members GO Category GO:0007519 skeletal muscle tissue development Database 0
Category members GO Category GO:0007595 lactation Database 0
Category members GO Category GO:0009968 negative regulation of signal transduction Database 0
Category members GO Category GO:0010524 positive regulation of calcium ion transport into cytosol Database 0
Category members GO Category GO:0010952 positive regulation of peptidase activity Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0019217 regulation of fatty acid metabolic process Database 0
Category members GO Category GO:0019915 lipid storage Database 0
Category members GO Category GO:0030301 cholesterol transport Database 0
Category members GO Category GO:0030514 negative regulation of BMP signaling pathway Database 0
Category members GO Category GO:0030857 negative regulation of epithelial cell differentiation Database 0
Category members GO Category GO:0030879 mammary gland development Database 0
Category members GO Category GO:0031295 T cell costimulation Database 0
Category members GO Category GO:0031397 negative regulation of protein ubiquitination Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0042310 vasoconstriction Database 0
Category members GO Category GO:0042632 cholesterol homeostasis Database 0
Category members GO Category GO:0043407 negative regulation of MAP kinase activity Database 0
Category members GO Category GO:0045019 negative regulation of nitric oxide biosynthetic process Database 0
Category members GO Category GO:0045907 positive regulation of vasoconstriction Database 0
Category members GO Category GO:0046209 nitric oxide metabolic process Database 0
Category members GO Category GO:0046426 negative regulation of JAK-STAT cascade Database 0
Category members GO Category GO:0048554 positive regulation of metalloenzyme activity Database 0
Category members GO Category GO:0050998 nitric-oxide synthase binding Database 0
Category members GO Category GO:0050999 regulation of nitric-oxide synthase activity Database 0
Category members GO Category GO:0051001 negative regulation of nitric-oxide synthase activity Database 0
Category members GO Category GO:0051259 protein oligomerization Database 0
Category members GO Category GO:0051260 protein homooligomerization Database 0
Category members GO Category GO:0051480 cytosolic calcium ion homeostasis Database 0
Category members GO Category GO:0051592 response to calcium ion Database 0
Category members GO Category GO:0051899 membrane depolarization Database 0
Category members GO Category GO:0055074 calcium ion homeostasis Database 0
Category members GO Category GO:0060056 mammary gland involution Database 0
Category members GO Category GO:0070836 caveola assembly Database 0
Category members GO Category GO:0071455 cellular response to hyperoxia Database 0


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