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Query: CXCR4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CXCR4 0 1.553 0.640 -0.440

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CXCR4 Ubiquitylation K327 0.978 0.329 _GSSLK(gl)ILSK_
CXCR4 Phosphorylation S319 0.861 -0.615 _TSAQHALTS(ph)VSR_

Background Information for CXCR4:


Pubmed-CXCR4 »
Uniprot-CXCR4 »
Biogrid-CXCR4 »
ProteomicsDB-CXCR4 »

Tumorportal-CXCR4 »
COSMIC-CXCR4 »
GenomeRNAi-CXCR4 »
Genecards-CXCR4


Protein-protein Interactions for CXCR4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait KCNK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMEM63B Cat. description Hein, Mann, Cell 2015
Category members IP bait B3GNT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC107 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD79B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GCNT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IPPK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPAR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NT5E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NTRK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM171 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VIPR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CXCR4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members GPCR_Rhodpsn IPR000276 2.56
Category members GPCR_Rhodpsn_7TM IPR017452 2.32
Category members 7TM_GPCR_olfarory/Srsx IPR019424 0.46
Category members Chemokine_rcpt IPR000355 0
Category members Chemokine_CXCR4 IPR001277 0


Protein complexes (CORUM database) featuring CXCR4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CXCR4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0003779 actin binding Database 5.41
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0031252 cell leading edge Database 2.52
Category members Pathway Pathway_1105 REACTOME_GPCR_LIGAND_BINDING 0 2.35
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0004930 G-protein coupled receptor activity Database 2.1
Category members Pathway Pathway_448 KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0 2.05
Category members Pathway Pathway_1182 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 0 1.69
Category members GO Category GO:0030426 growth cone Database 1.61
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members Pathway Pathway_859 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE 0 1.34
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members GO Category GO:0005769 early endosome Database 1.26
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0043130 ubiquitin binding Database 1.22
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0001618 virus receptor activity Database 0.83
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0030334 regulation of cell migration Database 0.61
Category members Pathway Pathway_1186 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS 0 0.54
Category members GO Category GO:0006954 inflammatory response Database 0.49
Category members Pathway Pathway_263 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 0 0.49
Category members Pathway Pathway_1215 REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION 0 0.32
Category members GO Category GO:0030260 entry into host cell Database 0.32
Category members Pathway Pathway_1132 KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION 0 0.3
Category members Pathway Pathway_1093 PID_SYNDECAN_4_PATHWAY 0 0.28
Category members Pathway Pathway_987 PID_S1P_S1P3_PATHWAY 0 0.28
Category members GO Category GO:0042098 T cell proliferation Database 0.21
Category members GO Category GO:0008354 germ cell migration Database 0.21
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members GO Category GO:0043217 myelin maintenance Database 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0016023 cytoplasmic membrane-bounded vesicle Database 0.17
Category members Pathway Pathway_525 BIOCARTA_CXCR4_PATHWAY 0 0.11
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members GO Category GO:0005770 late endosome Database 0.09
Category members GO Category GO:0015026 coreceptor activity Database 0.07
Category members GO Category GO:0048714 positive regulation of oligodendrocyte differentiation Database 0.07
Category members GO Category GO:0048699 generation of neurons Database 0.04
Category members GO Category GO:0001667 ameboidal cell migration Database 0.04
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members GO Category GO:0002407 dendritic cell chemotaxis Database 0.04
Category members Pathway Pathway_690 BIOCARTA_CCR5_PATHWAY 0 0.03
Category members GO Category GO:0009897 external side of plasma membrane Database 0
Category members Pathway Pathway_1212 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_547 PID_EPHRINB_REV_PATHWAY 0 0
Category members Pathway Pathway_899 BIOCARTA_NKT_PATHWAY 0 0
Category members GO Category GO:0000187 activation of MAPK activity Database 0
Category members GO Category GO:0001569 patterning of blood vessels Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0005764 lysosome Database 0
Category members GO Category GO:0007204 positive regulation of cytosolic calcium ion concentration Database 0
Category members GO Category GO:0007281 germ cell development Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0008045 motor neuron axon guidance Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0016494 C-X-C chemokine receptor activity Database 0
Category members GO Category GO:0019722 calcium-mediated signaling Database 0
Category members GO Category GO:0019955 cytokine binding Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0042119 neutrophil activation Database 0
Category members GO Category GO:0050920 regulation of chemotaxis Database 0
Category members GO Category GO:0061351 neural precursor cell proliferation Database 0
Category members GO Category GO:0071345 cellular response to cytokine stimulus Database 0


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