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Query: PPP3CA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PPP3CA 0 2.860 1.550 -1.230 -0.298 1.130
PPP3CA 0 2.860 1.550 -1.230 0.923 0.537

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PPP3CA Ubiquitylation K323 0.705 _AAVLK(gl)YENNVMNIR_
PPP3CA Ubiquitylation K56 0.132 _VDVLK(gl)NHLVK_
PPP3CA Ubiquitylation K405 0.078 _AIGK(gl)MAR_
PPP3CA Ubiquitylation K32 -0.137 _LTAK(gl)EVFDNDGKPR_

Background Information for PPP3CA:


Pubmed-PPP3CA »
Uniprot-PPP3CA »
Biogrid-PPP3CA »
ProteomicsDB-PPP3CA »

Tumorportal-PPP3CA »
COSMIC-PPP3CA »
GenomeRNAi-PPP3CA »
Genecards-PPP3CA


Protein-protein Interactions for PPP3CA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DEFA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM122A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLRG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NFATC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDHB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP3CA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RASSF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RCAN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RCAN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RCAN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMPD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM200A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PPP3CA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ser/Thr-sp_prot-phosphatase IPR006186 0.88
Category members Calcineurin-like_PHP_apaH IPR004843 0.24
Category members Metallo-depent_PP-like IPR029052 0.23


Protein complexes (CORUM database) featuring PPP3CA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 786 MR-UBC9-SRC1 complex Database 0.11
Category members Corum 6023 Calcineurin Database 0.05
Category members Corum 2266 PPP3CA-PPP3CA-RCAN1 complex Database 0
Category members Corum 517 Kinase-scaffold-phosphatase complex, PKA-AKAP79-CaN Database 0


Categories featuring PPP3CA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members GO Category GO:0006606 protein import into nucleus Database 1.81
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members Pathway Pathway_1023 PID_NFAT_3PATHWAY 0 1.46
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_305 REACTOME_DARPP_32_EVENTS 0 0.47
Category members Pathway Pathway_420 KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 0 0.39
Category members GO Category GO:0005955 calcineurin complex Database 0.39
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members GO Category GO:0030018 Z disc Database 0.32
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members Pathway Pathway_260 REACTOME_OPIOID_SIGNALLING 0 0.28
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_535 SIG_BCR_SIGNALING_PATHWAY 0 0.24
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members GO Category GO:0004723 calcium-dependent protein serine/threonine phosphatase activity Database 0.21
Category members Pathway Pathway_232 KEGG_LONG_TERM_POTENTIATION 0 0.21
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members Pathway Pathway_648 KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.19
Category members Pathway Pathway_686 BIOCARTA_BCR_PATHWAY 0 0.16
Category members Pathway Pathway_233 KEGG_CALCIUM_SIGNALING_PATHWAY 0 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_698 BIOCARTA_CALCINEURIN_PATHWAY 0 0.11
Category members GO Category GO:0004722 protein serine/threonine phosphatase activity Database 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0004721 phosphoprotein phosphatase activity Database 0.11
Category members GO Category GO:0035690 cellular response to drug Database 0.1
Category members GO Category GO:0033555 multicellular organismal response to stress Database 0.1
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Pathway Pathway_297 BIOCARTA_NDKDYNAMIN_PATHWAY 0 0.08
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0050804 regulation of synaptic transmission Database 0.05
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members Pathway Pathway_543 BIOCARTA_TCR_PATHWAY 0 0.03
Category members GO Category GO:0042110 T cell activation Database 0.02
Category members GO Category GO:0033192 calmodulin-dependent protein phosphatase activity Database 0.01
Category members Pathway Pathway_1144 BIOCARTA_MEF2D_PATHWAY 0 0
Category members Pathway Pathway_218 BIOCARTA_GPCR_PATHWAY 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_421 BIOCARTA_NOS1_PATHWAY 0 0
Category members Pathway Pathway_423 PID_IL12_2PATHWAY 0 0
Category members Pathway Pathway_436 KEGG_VEGF_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_524 BIOCARTA_FMLP_PATHWAY 0 0
Category members Pathway Pathway_540 PID_BCR_5PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_574 BIOCARTA_HDAC_PATHWAY 0 0
Category members Pathway Pathway_597 BIOCARTA_FCER1_PATHWAY 0 0
Category members Pathway Pathway_641 BIOCARTA_NFAT_PATHWAY 0 0
Category members Pathway Pathway_646 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0 0
Category members Pathway Pathway_676 BIOCARTA_CK1_PATHWAY 0 0
Category members Pathway Pathway_702 BIOCARTA_VIP_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_732 PID_TCR_CALCIUM_PATHWAY 0 0
Category members Pathway Pathway_897 PID_CD8_TCR_DOWNSTREAM_PATHWAY 0 0
Category members Pathway Pathway_904 PID_IL12_STAT4_PATHWAY 0 0
Category members Pathway Pathway_938 BIOCARTA_PGC1A_PATHWAY 0 0
Category members GO Category GO:0001975 response to amphetamine Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0006816 calcium ion transport Database 0
Category members GO Category GO:0006950 response to stress Database 0
Category members GO Category GO:0008144 drug binding Database 0
Category members GO Category GO:0016311 dephosphorylation Database 0
Category members GO Category GO:0019722 calcium-mediated signaling Database 0
Category members GO Category GO:0046676 negative regulation of insulin secretion Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0048741 skeletal muscle fiber development Database 0
Category members GO Category GO:0051592 response to calcium ion Database 0
Category members GO Category GO:0060079 regulation of excitatory postsynaptic membrane potential Database 0
Category members GO Category GO:0071333 cellular response to glucose stimulus Database 0


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