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Query: CALM3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CALM3 1 -0.789 -0.190 0.120 1.911
CALM3 1 -0.789 -0.190 0.120 0.877 -4.680

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CALM3 Ubiquitylation K142 0.922 _VFDK(gl)DGNGYISAAELR_
CALM3 Ubiquitylation K78 0.061 _DGDGTITTK(gl)ELGTVMR_

Background Information for CALM3:


Pubmed-CALM3 »
Uniprot-CALM3 »
Biogrid-CALM3 »
ProteomicsDB-CALM3 »

Tumorportal-CALM3 »
COSMIC-CALM3 »
GenomeRNAi-CALM3 »
Genecards-CALM3


Protein-protein Interactions for CALM3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CAMK1D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD33 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYLK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CALM3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EF_hand_dom IPR002048 0
Category members EF-hand_Ca_insen IPR014837 0


Protein complexes (CORUM database) featuring CALM3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1223 H2AX complex, isolated from cells without IR exposure Database 8.51
Category members Corum 2242 TGM2-HD-CALM1 complex Database 0
Category members Corum 4158 HSP90-FKBP38-CAM-Ca(2+) complex Database 0
Category members Corum 5189 YWHAQ-CALM1-CABIN1 complex Database 0
Category members Corum 5526 CALM1-FKBP38-BCL2 complex Database 0


Categories featuring CALM3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members Pathway Pathway_35 REACTOME_GLUCOSE_METABOLISM 0 1.79
Category members GO Category GO:0030426 growth cone Database 1.61
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members Pathway Pathway_267 KEGG_OLFACTORY_TRANSDUCTION 0 0.75
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0005876 spindle microtubule Database 0.68
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members Pathway Pathway_305 REACTOME_DARPP_32_EVENTS 0 0.47
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_214 REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 0 0.33
Category members GO Category GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity Database 0.33
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0030235 nitric-oxide synthase regulator activity Database 0.28
Category members Pathway Pathway_260 REACTOME_OPIOID_SIGNALLING 0 0.28
Category members GO Category GO:0006006 glucose metabolic process Database 0.28
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0007603 phototransduction, visible light Database 0.25
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members Pathway Pathway_66 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS 0 0.22
Category members GO Category GO:0034704 calcium channel complex Database 0.21
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members Pathway Pathway_232 KEGG_LONG_TERM_POTENTIATION 0 0.21
Category members GO Category GO:0005980 glycogen catabolic process Database 0.2
Category members GO Category GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity Database 0.19
Category members GO Category GO:0048306 calcium-dependent protein binding Database 0.17
Category members Pathway Pathway_686 BIOCARTA_BCR_PATHWAY 0 0.16
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_233 KEGG_CALCIUM_SIGNALING_PATHWAY 0 0.13
Category members GO Category GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Database 0.12
Category members Pathway Pathway_698 BIOCARTA_CALCINEURIN_PATHWAY 0 0.11
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0005513 detection of calcium ion Database 0.1
Category members Pathway Pathway_297 BIOCARTA_NDKDYNAMIN_PATHWAY 0 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0030017 sarcomere Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0032465 regulation of cytokinesis Database 0.05
Category members GO Category GO:0016056 rhodopsin mediated signaling pathway Database 0.04
Category members Pathway Pathway_543 BIOCARTA_TCR_PATHWAY 0 0.03
Category members Pathway Pathway_690 BIOCARTA_CCR5_PATHWAY 0 0.03
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members Pathway Pathway_251 REACTOME_DAG_AND_IP3_SIGNALING 0 0.02
Category members GO Category GO:0030234 enzyme regulator activity Database 0.02
Category members Pathway Pathway_160 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0 0.01
Category members GO Category GO:0022400 regulation of rhodopsin mediated signaling pathway Database 0
Category members Pathway Pathway_1119 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR 0 0
Category members Pathway Pathway_1144 BIOCARTA_MEF2D_PATHWAY 0 0
Category members Pathway Pathway_1167 BIOCARTA_CACAM_PATHWAY 0 0
Category members Pathway Pathway_1169 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII 0 0
Category members Pathway Pathway_1190 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_218 BIOCARTA_GPCR_PATHWAY 0 0
Category members Pathway Pathway_222 REACTOME_CA_DEPENDENT_EVENTS 0 0
Category members Pathway Pathway_224 REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS 0 0
Category members Pathway Pathway_227 REACTOME_PLC_BETA_MEDIATED_EVENTS 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members Pathway Pathway_238 REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS 0 0
Category members Pathway Pathway_244 KEGG_MELANOGENESIS 0 0
Category members Pathway Pathway_257 KEGG_GNRH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_261 REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_301 BIOCARTA_NO1_PATHWAY 0 0
Category members Pathway Pathway_421 BIOCARTA_NOS1_PATHWAY 0 0
Category members Pathway Pathway_435 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION 0 0
Category members Pathway Pathway_438 REACTOME_ENOS_ACTIVATION_AND_REGULATION 0 0
Category members Pathway Pathway_439 BIOCARTA_GCR_PATHWAY 0 0
Category members Pathway Pathway_488 KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 0 0
Category members Pathway Pathway_524 BIOCARTA_FMLP_PATHWAY 0 0
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_574 BIOCARTA_HDAC_PATHWAY 0 0
Category members Pathway Pathway_597 BIOCARTA_FCER1_PATHWAY 0 0
Category members Pathway Pathway_641 BIOCARTA_NFAT_PATHWAY 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members Pathway Pathway_659 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS 0 0
Category members Pathway Pathway_678 REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING 0 0
Category members Pathway Pathway_693 BIOCARTA_PYK2_PATHWAY 0 0
Category members Pathway Pathway_702 BIOCARTA_VIP_PATHWAY 0 0
Category members Pathway Pathway_704 BIOCARTA_BIOPEPTIDES_PATHWAY 0 0
Category members Pathway Pathway_935 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS 0 0
Category members Pathway Pathway_938 BIOCARTA_PGC1A_PATHWAY 0 0
Category members Pathway Pathway_949 REACTOME_SMOOTH_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_950 REACTOME_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_998 BIOCARTA_AT1R_PATHWAY 0 0
Category members Disease phenotype VENTRICULAR_TACHYCARDIA_CATECHOLAMINERGIC_POLYMORPHIC_4 VENTRICULAR TACHYCARDIA CATECHOLAMINERGIC POLYMORPHIC 4 Database 0
Category members GO Category GO:0001975 response to amphetamine Database 0
Category members GO Category GO:0002027 regulation of heart rate Database 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0006936 muscle contraction Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007190 activation of adenylate cyclase activity Database 0
Category members GO Category GO:0007202 activation of phospholipase C activity Database 0
Category members GO Category GO:0008179 adenylate cyclase binding Database 0
Category members GO Category GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Database 0
Category members GO Category GO:0019722 calcium-mediated signaling Database 0
Category members GO Category GO:0030801 positive regulation of cyclic nucleotide metabolic process Database 0
Category members GO Category GO:0031432 titin binding Database 0
Category members GO Category GO:0031800 type 3 metabotropic glutamate receptor binding Database 0
Category members GO Category GO:0031996 thioesterase binding Database 0
Category members GO Category GO:0031997 N-terminal myristoylation domain binding Database 0
Category members GO Category GO:0032516 positive regulation of phosphoprotein phosphatase activity Database 0
Category members GO Category GO:0035307 positive regulation of protein dephosphorylation Database 0
Category members GO Category GO:0043274 phospholipase binding Database 0
Category members GO Category GO:0043548 phosphatidylinositol 3-kinase binding Database 0
Category members GO Category GO:0043647 inositol phosphate metabolic process Database 0
Category members GO Category GO:0046209 nitric oxide metabolic process Database 0
Category members GO Category GO:0050998 nitric-oxide synthase binding Database 0
Category members GO Category GO:0050999 regulation of nitric-oxide synthase activity Database 0
Category members GO Category GO:0051000 positive regulation of nitric-oxide synthase activity Database 0
Category members GO Category GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity Database 0
Category members GO Category GO:0051412 response to corticosterone Database 0
Category members GO Category GO:0051592 response to calcium ion Database 0
Category members GO Category GO:0055117 regulation of cardiac muscle contraction Database 0
Category members GO Category GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity Database 0


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