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Query: GNAI3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GNAI3 1 0.984 0.750 -0.890
GNAI3 1 0.984 0.750 -0.890 0.217 -0.334 -0.374

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GNAI3 Ubiquitylation K29 0.529 -0.094 _NLREDGEK(gl)AAK_
GNAI3 Ubiquitylation K349 -0.221 -0.339 _NNLK(gl)ECGLY_
GNAI3 Ubiquitylation K53 -1.168 -0.413 _LLLLGAGESGK(gl)STIVK_
GNAI3 Ubiquitylation K92 1.569 _LK(gl)IDFGEAAR_

Background Information for GNAI3:


Pubmed-GNAI3 »
Uniprot-GNAI3 »
Biogrid-GNAI3 »
ProteomicsDB-GNAI3 »

Tumorportal-GNAI3 »
COSMIC-GNAI3 »
GenomeRNAi-GNAI3 »
Genecards-GNAI3


Protein-protein Interactions for GNAI3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait GNAI1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNAI3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNG4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GNAI3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Small_GTPase_ARF/SAR IPR006689 0.8
Category members GproteinA_insert IPR011025 0.18
Category members Gprotein_alpha_su IPR001019 0.02
Category members Gprotein_alpha_I IPR001408 0
Category members Fungi_Gprotein_alpha IPR002975 0


Protein complexes (CORUM database) featuring GNAI3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring GNAI3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members GO Category GO:0006906 vesicle fusion Database 1.28
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0051301 cell division Database 1.15
Category members Pathway Pathway_237 PID_LYSOPHOSPHOLIPID_PATHWAY 0 1.09
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Pathway Pathway_736 PID_S1P_META_PATHWAY 0 0.73
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members Pathway Pathway_1078 PID_S1P_S1P2_PATHWAY 0 0.62
Category members Pathway Pathway_220 KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 0 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_263 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 0 0.49
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0030496 midbody Database 0.39
Category members Pathway Pathway_286 KEGG_LONG_TERM_DEPRESSION 0 0.31
Category members Pathway Pathway_260 REACTOME_OPIOID_SIGNALLING 0 0.28
Category members Pathway Pathway_987 PID_S1P_S1P3_PATHWAY 0 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members Pathway Pathway_253 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 0 0.26
Category members Pathway Pathway_228 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS 0 0.24
Category members Pathway Pathway_433 PID_ER_NONGENOMIC_PATHWAY 0 0.23
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members Pathway Pathway_428 PID_THROMBIN_PAR1_PATHWAY 0 0.18
Category members Pathway Pathway_696 PID_S1P_S1P4_PATHWAY 0 0.18
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_546 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 0 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_213 KEGG_GAP_JUNCTION 0 0.11
Category members GO Category GO:0031234 extrinsic to cytoplasmic side of plasma membrane Database 0.1
Category members Pathway Pathway_984 PID_HEDGEHOG_GLI_PATHWAY 0 0.1
Category members GO Category GO:0019001 guanyl nucleotide binding Database 0.07
Category members Pathway Pathway_721 REACTOME_SIGNAL_AMPLIFICATION 0 0.06
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members GO Category GO:0031683 G-protein beta/gamma-subunit complex binding Database 0.02
Category members Pathway Pathway_1100 REACTOME_G_PROTEIN_ACTIVATION 0 0
Category members Pathway Pathway_1106 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_211 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY 0 0
Category members Pathway Pathway_215 REACTOME_GABA_RECEPTOR_ACTIVATION 0 0
Category members Pathway Pathway_219 REACTOME_GABA_B_RECEPTOR_ACTIVATION 0 0
Category members Pathway Pathway_227 REACTOME_PLC_BETA_MEDIATED_EVENTS 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members Pathway Pathway_234 PID_ENDOTHELIN_PATHWAY 0 0
Category members Pathway Pathway_244 KEGG_MELANOGENESIS 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_432 PID_SHP2_PATHWAY 0 0
Category members Pathway Pathway_624 PID_AR_NONGENOMIC_PATHWAY 0 0
Category members Pathway Pathway_655 PID_CXCR3_PATHWAY 0 0
Category members Pathway Pathway_683 PID_S1P_S1P1_PATHWAY 0 0
Category members Disease phenotype AURICULOCONDYLAR_SYNDROME AURICULOCONDYLAR SYNDROME Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005834 heterotrimeric G-protein complex Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Database 0
Category members GO Category GO:0007194 negative regulation of adenylate cyclase activity Database 0
Category members GO Category GO:0031821 G-protein coupled serotonin receptor binding Database 0
Category members GO Category GO:0032794 GTPase activating protein binding Database 0
Category members GO Category GO:0042588 zymogen granule Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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