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Query: CDK5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDK5 0 3.722 -1.100 1.740 -0.236 1.063 0.312

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CDK5 Ubiquitylation K56 0.606 0.237 _EICLLK(gl)ELK_

Background Information for CDK5:


Pubmed-CDK5 »
Uniprot-CDK5 »
Biogrid-CDK5 »
ProteomicsDB-CDK5 »

Tumorportal-CDK5 »
COSMIC-CDK5 »
GenomeRNAi-CDK5 »
Genecards-CDK5


Protein-protein Interactions for CDK5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AURKC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCND1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCND2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCND3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNI2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK5R1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CNPPD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FIBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDK5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring CDK5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 313 Cell cycle kinase complex CDK5 Database 0


Categories featuring CDK5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006913 nucleocytoplasmic transport Database 2.96
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members GO Category GO:0030426 growth cone Database 1.61
Category members Pathway Pathway_729 PID_LIS1_PATHWAY 0 1.41
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0051301 cell division Database 1.15
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members GO Category GO:0045786 negative regulation of cell cycle Database 0.93
Category members GO Category GO:0030866 cortical actin cytoskeleton organization Database 0.89
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0014044 Schwann cell development Database 0.62
Category members GO Category GO:0030334 regulation of cell migration Database 0.61
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_305 REACTOME_DARPP_32_EVENTS 0 0.47
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0021987 cerebral cortex development Database 0.37
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members Pathway Pathway_548 BIOCARTA_RAC1_PATHWAY 0 0.3
Category members GO Category GO:0046875 ephrin receptor binding Database 0.3
Category members Pathway Pathway_260 REACTOME_OPIOID_SIGNALLING 0 0.28
Category members GO Category GO:0021819 layer formation in cerebral cortex Database 0.27
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0051402 neuron apoptotic process Database 0.25
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0046826 negative regulation of protein export from nucleus Database 0.23
Category members GO Category GO:0061001 regulation of dendritic spine morphogenesis Database 0.23
Category members GO Category GO:0048813 dendrite morphogenesis Database 0.23
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0016310 phosphorylation Database 0.21
Category members GO Category GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex Database 0.21
Category members GO Category GO:0006887 exocytosis Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_1141 BIOCARTA_P35ALZHEIMERS_PATHWAY 0 0.19
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members Pathway Pathway_1282 REACTOME_CRMPS_IN_SEMA3A_SIGNALING 0 0.17
Category members GO Category GO:0045956 positive regulation of calcium ion-dependent exocytosis Database 0.16
Category members GO Category GO:0048167 regulation of synaptic plasticity Database 0.14
Category members GO Category GO:0021549 cerebellum development Database 0.14
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0035249 synaptic transmission, glutamatergic Database 0.13
Category members GO Category GO:0031175 neuron projection development Database 0.12
Category members GO Category GO:0033136 serine phosphorylation of STAT3 protein Database 0.11
Category members GO Category GO:0071156 regulation of cell cycle arrest Database 0.11
Category members GO Category GO:0004693 cyclin-dependent protein serine/threonine kinase activity Database 0.08
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0045211 postsynaptic membrane Database 0.06
Category members GO Category GO:0045860 positive regulation of protein kinase activity Database 0.06
Category members GO Category GO:0030175 filopodium Database 0.05
Category members GO Category GO:0048488 synaptic vesicle endocytosis Database 0.05
Category members GO Category GO:0043204 perikaryon Database 0.05
Category members GO Category GO:0019233 sensory perception of pain Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0050321 tau-protein kinase activity Database 0.04
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members GO Category GO:0021954 central nervous system neuron development Database 0.02
Category members GO Category GO:0048675 axon extension Database 0.01
Category members GO Category GO:0018107 peptidyl-threonine phosphorylation Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_558 PID_REELIN_PATHWAY 0 0.01
Category members Pathway Pathway_665 PID_EPHA_FWDPATHWAY 0 0.01
Category members Pathway Pathway_1006 PID_MAPK_TRK_PATHWAY 0 0
Category members Pathway Pathway_1116 BIOCARTA_CDK5_PATHWAY 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_676 BIOCARTA_CK1_PATHWAY 0 0
Category members Pathway Pathway_704 BIOCARTA_BIOPEPTIDES_PATHWAY 0 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0001963 synaptic transmission, dopaminergic Database 0
Category members GO Category GO:0005176 ErbB-2 class receptor binding Database 0
Category members GO Category GO:0007160 cell-matrix adhesion Database 0
Category members GO Category GO:0007416 synapse assembly Database 0
Category members GO Category GO:0007519 skeletal muscle tissue development Database 0
Category members GO Category GO:0008045 motor neuron axon guidance Database 0
Category members GO Category GO:0008306 associative learning Database 0
Category members GO Category GO:0008542 visual learning Database 0
Category members GO Category GO:0009611 response to wounding Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0014069 postsynaptic density Database 0
Category members GO Category GO:0016079 synaptic vesicle exocytosis Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0021537 telencephalon development Database 0
Category members GO Category GO:0021695 cerebellar cortex development Database 0
Category members GO Category GO:0021766 hippocampus development Database 0
Category members GO Category GO:0022038 corpus callosum development Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0030182 neuron differentiation Database 0
Category members GO Category GO:0030517 negative regulation of axon extension Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0031397 negative regulation of protein ubiquitination Database 0
Category members GO Category GO:0031594 neuromuscular junction Database 0
Category members GO Category GO:0031914 negative regulation of synaptic plasticity Database 0
Category members GO Category GO:0032092 positive regulation of protein binding Database 0
Category members GO Category GO:0032801 receptor catabolic process Database 0
Category members GO Category GO:0035418 protein localization to synapse Database 0
Category members GO Category GO:0042220 response to cocaine Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0043113 receptor clustering Database 0
Category members GO Category GO:0043125 ErbB-3 class receptor binding Database 0
Category members GO Category GO:0043525 positive regulation of neuron apoptotic process Database 0
Category members GO Category GO:0045055 regulated secretory pathway Database 0
Category members GO Category GO:0048148 behavioral response to cocaine Database 0
Category members GO Category GO:0048709 oligodendrocyte differentiation Database 0
Category members GO Category GO:0048812 neuron projection morphogenesis Database 0
Category members GO Category GO:0060078 regulation of postsynaptic membrane potential Database 0
Category members GO Category GO:0060079 regulation of excitatory postsynaptic membrane potential Database 0
Category members GO Category GO:0070509 calcium ion import Database 0


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