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Query: GNAL

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GNAL 0 -0.311 1.660 -1.170
GNAL 0 -0.311 1.660 -1.170 -0.166 -0.094 0.032 0.420 0.504

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GNAL Ubiquitylation K58 -1.182 0.161 _STIVK(gl)QM(ox)R_
GNAL Ubiquitylation K53 -1.168 -0.413 _LLLLGAGESGK(gl)STIVK_

Background Information for GNAL:


Pubmed-GNAL »
Uniprot-GNAL »
Biogrid-GNAL »
ProteomicsDB-GNAL »

Tumorportal-GNAL »
COSMIC-GNAL »
GenomeRNAi-GNAL »
Genecards-GNAL


Protein-protein Interactions for GNAL
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CHIA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FNDC5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNAS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGED2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GNAL
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Small_GTPase_ARF/SAR IPR006689 0.8
Category members GproteinA_insert IPR011025 0.18
Category members Gprotein_alpha_su IPR001019 0.02
Category members Gprotein_alpha_S IPR000367 0


Protein complexes (CORUM database) featuring GNAL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring GNAL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_1198 REACTOME_OLFACTORY_SIGNALING_PATHWAY 0 0.82
Category members Pathway Pathway_267 KEGG_OLFACTORY_TRANSDUCTION 0 0.75
Category members Pathway Pathway_260 REACTOME_OPIOID_SIGNALLING 0 0.28
Category members Pathway Pathway_433 PID_ER_NONGENOMIC_PATHWAY 0 0.23
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members Pathway Pathway_233 KEGG_CALCIUM_SIGNALING_PATHWAY 0 0.13
Category members GO Category GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway Database 0.11
Category members GO Category GO:0031234 extrinsic to cytoplasmic side of plasma membrane Database 0.1
Category members GO Category GO:0001664 G-protein coupled receptor binding Database 0.09
Category members GO Category GO:0019001 guanyl nucleotide binding Database 0.07
Category members GO Category GO:0031683 G-protein beta/gamma-subunit complex binding Database 0.02
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_211 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY 0 0
Category members Pathway Pathway_215 REACTOME_GABA_RECEPTOR_ACTIVATION 0 0
Category members Pathway Pathway_219 REACTOME_GABA_B_RECEPTOR_ACTIVATION 0 0
Category members Pathway Pathway_225 PID_LPA4_PATHWAY 0 0
Category members Pathway Pathway_226 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members Pathway Pathway_234 PID_ENDOTHELIN_PATHWAY 0 0
Category members GO Category GO:0001975 response to amphetamine Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005834 heterotrimeric G-protein complex Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007190 activation of adenylate cyclase activity Database 0
Category members GO Category GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway Database 0
Category members GO Category GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Database 0
Category members GO Category GO:0007608 sensory perception of smell Database 0
Category members GO Category GO:0031000 response to caffeine Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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