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Query: PPP2R1A

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PPP2R1A 1 4.279 -0.260 -0.200 0.714 0.973
PPP2R1A 1 4.279 -0.260 -0.200 1.697 1.450 -1.553
PPP2R1A 1 4.279 -0.260 -0.200 -0.003 -0.196 0.057

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PPP2R1A Ubiquitylation K467 0.890 _EAATSNLK(gl)K_
PPP2R1A Ubiquitylation K468 0.890 _EAATSNLK(gl)K_
PPP2R1A Ubiquitylation K307 0.224 0.500 _VK(gl)EFCENLSADCR_
PPP2R1A Ubiquitylation K107 0.584 0.441 _DK(gl)AVESLR_
PPP2R1A Ubiquitylation K266 0.464 0.338 _YMVADK(gl)FTELQK_
PPP2R1A Ubiquitylation K255 0.301 0.202 _QAAEDK(gl)SWR_
PPP2R1A Ubiquitylation K163 0.106 0.149 _VSSAVK(gl)AELR_
PPP2R1A Ubiquitylation K188 0.395 0.130 _AAASK(gl)LGEFAK_
PPP2R1A Ubiquitylation K542 -0.187 _FNVAK(gl)SLQK_
PPP2R1A Ubiquitylation K175 -0.351 _ASNAVK(gl)AEIR_
PPP2R1A Ubiquitylation K284 -0.575 _FSELQK(gl)AMGPK_
PPP2R1A Ubiquitylation K34 0.304 _K(gl)LSTIALALGVER_

Background Information for PPP2R1A:


Pubmed-PPP2R1A »
Uniprot-PPP2R1A »
Biogrid-PPP2R1A »
ProteomicsDB-PPP2R1A »

Tumorportal-PPP2R1A »
COSMIC-PPP2R1A »
GenomeRNAi-PPP2R1A »
Genecards-PPP2R1A


Protein-protein Interactions for PPP2R1A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ABI1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait FAM40A Cat. description Hein, Mann, Cell 2015
Category members IP bait FAN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FGFR1OP Cat. description Hein, Mann, Cell 2015
Category members IP bait FGFR1OP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GTF2E2 Cat. description Hein, Mann, Cell 2015
Category members IP bait INTS4 Cat. description Hein, Mann, Cell 2015
Category members IP bait MARK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NABP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NHSL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CA Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CB Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R1A Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R1B Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R2A Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R2D Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R3A Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R5C Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R5D Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP4C Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP4R1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SAMHD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SGOL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SIKE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SOGA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait STRN Cat. description Hein, Mann, Cell 2015
Category members IP bait STRN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait VWA9 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDCA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM122A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IER2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCAPD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2CB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2R2C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2R2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2R3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRR14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERTAD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBCCD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF114 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF331 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF517 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF550 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PPP2R1A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members HEAT IPR000357 3.83
Category members HEAT_type_2 IPR021133 0.74


Protein complexes (CORUM database) featuring PPP2R1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1131 RFC2-RIalpha complex Database 0.2
Category members Corum 1543 PPP2CA-PPP2R1A complex Database 0.15
Category members Corum 5876 PPP2R1A-PPP2R1B-PPP2CA-PPME1-EIF4A1 complex Database 0.08
Category members Corum 1132 RFC2-RIalpha complex Database 0
Category members Corum 1544 PPP2CA-PPP2R1A-PPP2R3A complex Database 0
Category members Corum 5211 RAF1-PPP2-PIN1 complex Database 0


Categories featuring PPP2R1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_770 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX 0 INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005488 binding Database 9.32
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_57 REACTOME_GLYCOLYSIS 0 4.41
Category members Pathway Pathway_865 PID_ATR_PATHWAY 0 3.46
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_807 REACTOME_SIGNALING_BY_WNT 0 2.74
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members Pathway Pathway_726 REACTOME_MITOTIC_PROMETAPHASE 0 2.41
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members Pathway Pathway_35 REACTOME_GLUCOSE_METABOLISM 0 1.79
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members GO Category GO:0015630 microtubule cytoskeleton Database 1.34
Category members Pathway Pathway_1257 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE 0 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members Pathway Pathway_936 REACTOME_CTLA4_INHIBITORY_SIGNALING 0 0.77
Category members Pathway Pathway_662 PID_IL8_CXCR2_PATHWAY 0 0.62
Category members Pathway Pathway_123 BIOCARTA_CHREBP2_PATHWAY 0 0.61
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_305 REACTOME_DARPP_32_EVENTS 0 0.47
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members Pathway Pathway_728 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 0 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members Pathway Pathway_332 REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 0 0.36
Category members Pathway Pathway_730 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 0 0.33
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members Pathway Pathway_286 KEGG_LONG_TERM_DEPRESSION 0 0.31
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members Pathway Pathway_720 REACTOME_PLATELET_SENSITIZATION_BY_LDL 0 0.29
Category members GO Category GO:0000775 chromosome, centromeric region Database 0.29
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members Pathway Pathway_260 REACTOME_OPIOID_SIGNALLING 0 0.28
Category members GO Category GO:0007084 mitotic nuclear envelope reassembly Database 0.24
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members Pathway Pathway_1001 REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES 0 0.2
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members Pathway Pathway_1028 PID_PLK1_PATHWAY 0 0.16
Category members GO Category GO:0006275 regulation of DNA replication Database 0.14
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0003823 antigen binding Database 0.13
Category members Pathway Pathway_797 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 0 0.12
Category members GO Category GO:0004722 protein serine/threonine phosphatase activity Database 0.11
Category members Pathway Pathway_312 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 0 0.11
Category members Pathway Pathway_813 REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 0 0.11
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Pathway Pathway_810 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING 0 0.09
Category members Pathway Pathway_285 REACTOME_PLATELET_HOMEOSTASIS 0 0.08
Category members GO Category GO:0030111 regulation of Wnt signaling pathway Database 0.08
Category members Pathway Pathway_620 REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 0 0.06
Category members Pathway Pathway_814 REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 0 0.05
Category members Pathway Pathway_996 REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 0 0.05
Category members Pathway Pathway_834 REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 0 0.04
Category members GO Category GO:0019932 second-messenger-mediated signaling Database 0.04
Category members Pathway Pathway_791 REACTOME_G1_PHASE 0 0.02
Category members GO Category GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein Database 0.02
Category members Pathway Pathway_1063 REACTOME_ERK_MAPK_TARGETS 0 0
Category members Pathway Pathway_1064 REACTOME_ERKS_ARE_INACTIVATED 0 0
Category members Pathway Pathway_1065 REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION 0 0
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members Pathway Pathway_783 REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING 0 0
Category members GO Category GO:0000159 protein phosphatase type 2A complex Database 0
Category members GO Category GO:0000188 inactivation of MAPK activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0006672 ceramide metabolic process Database 0
Category members GO Category GO:0008601 protein phosphatase type 2A regulator activity Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0030155 regulation of cell adhesion Database 0
Category members GO Category GO:0040008 regulation of growth Database 0
Category members GO Category GO:0045595 regulation of cell differentiation Database 0


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