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Query: PPP1CA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PPP1CA 3 6.646 2.150 -0.860
PPP1CA 3 6.646 2.150 -0.860 -0.250 0.634 0.981 -0.108 0.171

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PPP1CA Ubiquitylation K269 2.628 2.591 _AHQVVEDGYEFFAK(gl)R_
PPP1CA Ubiquitylation K156 0.883 1.047 _YNIK(gl)LWK_
PPP1CA Ubiquitylation K150 0.321 0.619 _IYGFYDECK(gl)RR_
PPP1CA Ubiquitylation K50 -0.131 0.478 _GLCLK(gl)SR_
PPP1CA Ubiquitylation K6 0.594 0.414 _(ac)SDSEK(gl)LNLDSIIGR_
PPP1CA Ubiquitylation K247 0.313 _FLHK(gl)HDLDLICR_

Background Information for PPP1CA:


Pubmed-PPP1CA »
Uniprot-PPP1CA »
Biogrid-PPP1CA »
ProteomicsDB-PPP1CA »

Tumorportal-PPP1CA »
COSMIC-PPP1CA »
GenomeRNAi-PPP1CA »
Genecards-PPP1CA


Protein-protein Interactions for PPP1CA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait ARRB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ASF1A Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait FUS Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MATR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTX2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO5C Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP153 Cat. description Hein, Mann, Cell 2015
Category members IP bait PARD6B Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CC Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1R10 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1R3B Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1R7 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TAF15 Cat. description Hein, Mann, Cell 2015
Category members IP bait TOX4 Cat. description Hein, Mann, Cell 2015
Category members IP bait YAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GPN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIH1D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR2E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1CA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1CC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1R16B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1R7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SH2D4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UXT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR92 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PPP1CA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ser/Thr-sp_prot-phosphatase IPR006186 0.88
Category members Calcineurin-like_PHP_apaH IPR004843 0.24
Category members Metallo-depent_PP-like IPR029052 0.23


Protein complexes (CORUM database) featuring PPP1CA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1183 CDC5L complex Database 2.07
Category members Corum 180 PNUTS-PP1 complex Database 0.34


Categories featuring PPP1CA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members GO Category GO:0051301 cell division Database 1.15
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members GO Category GO:0043197 dendritic spine Database 0.86
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_995 PID_ALK1_PATHWAY 0 0.69
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0005981 regulation of glycogen catabolic process Database 0.54
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members Pathway Pathway_305 REACTOME_DARPP_32_EVENTS 0 0.47
Category members GO Category GO:0042587 glycogen granule Database 0.44
Category members GO Category GO:0030324 lung development Database 0.39
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_794 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 0 0.29
Category members Pathway Pathway_260 REACTOME_OPIOID_SIGNALLING 0 0.28
Category members GO Category GO:0005979 regulation of glycogen biosynthetic process Database 0.26
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0070688 MLL5-L complex Database 0.25
Category members Pathway Pathway_816 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING 0 0.23
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members Pathway Pathway_1174 BIOCARTA_EIF2_PATHWAY 0 0.22
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members Pathway Pathway_232 KEGG_LONG_TERM_POTENTIATION 0 0.21
Category members GO Category GO:0000164 protein phosphatase type 1 complex Database 0.14
Category members GO Category GO:0004722 protein serine/threonine phosphatase activity Database 0.11
Category members GO Category GO:0004721 phosphoprotein phosphatase activity Database 0.11
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0005977 glycogen metabolic process Database 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members Pathway Pathway_496 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS 0 0.07
Category members GO Category GO:0043204 perikaryon Database 0.05
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members Pathway Pathway_160 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0 0.01
Category members Pathway Pathway_1133 PID_BMP_PATHWAY 0 0
Category members Pathway Pathway_1153 BIOCARTA_AKAPCENTROSOME_PATHWAY 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_490 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 0 0
Category members Pathway Pathway_676 BIOCARTA_CK1_PATHWAY 0 0
Category members Pathway Pathway_879 BIOCARTA_AKAP95_PATHWAY 0 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0019433 triglyceride catabolic process Database 0
Category members GO Category GO:0043021 ribonucleoprotein complex binding Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048754 branching morphogenesis of an epithelial tube Database 0


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