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Query: PRKACB

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRKACB 0 0.355 1.740 -1.200 -1.064
PRKACB 0 0.355 1.740 -1.200 -1.005 -0.697 0.234 0.487

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRKACB Ubiquitylation K93 0.839 0.714 _QIEHTLNEK(gl)R_
PRKACB Phosphorylation T245 -0.116 -0.102 _TWT(ph)LCGTPEYLAPEIILSK_
PRKACB Phosphorylation T243 -0.835 _T(ph)WTLCGTPEYLAPEIILSK_
PRKACB Ubiquitylation K30 -0.143 _AKEDFLKK(gl)_

Background Information for PRKACB:


Pubmed-PRKACB »
Uniprot-PRKACB »
Biogrid-PRKACB »
ProteomicsDB-PRKACB »

Tumorportal-PRKACB »
COSMIC-PRKACB »
GenomeRNAi-PRKACB »
Genecards-PRKACB


Protein-protein Interactions for PRKACB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AKAP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK5RAP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP170P1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNLL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FGFR1OP Cat. description Hein, Mann, Cell 2015
Category members IP bait GSK3B Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKACB Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKAR2A Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKAR2B Cat. description Hein, Mann, Cell 2015
Category members IP bait SMN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait USO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait AKAP14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP2M1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BMP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCLRE1C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DFFB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MLF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPS15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NAPG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NPAS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDE4DIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PKIG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RABGGTB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAPGEF5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAPA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PRKACB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members AGC-kinase_C IPR000961 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring PRKACB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 518 AKAP250-PKA-PDE4D complex Database 0.17
Category members Corum 621 AKAP250-PKA-PDE4D complex Database 0.17
Category members Corum 879 PRKAC-AKAP5-ADRB1 complex Database 0.17
Category members Corum 520 KCNQ1 macromolecular complex Database 0


Categories featuring PRKACB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members Pathway Pathway_35 REACTOME_GLUCOSE_METABOLISM 0 1.79
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members GO Category GO:0006094 gluconeogenesis Database 1.42
Category members Pathway Pathway_33 REACTOME_GLUCONEOGENESIS 0 1.41
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Pathway Pathway_267 KEGG_OLFACTORY_TRANSDUCTION 0 0.75
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_123 BIOCARTA_CHREBP2_PATHWAY 0 0.61
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members Pathway Pathway_220 KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 0 0.6
Category members Pathway Pathway_305 REACTOME_DARPP_32_EVENTS 0 0.47
Category members Pathway Pathway_187 KEGG_VIBRIO_CHOLERAE_INFECTION 0 0.44
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Pathway Pathway_214 REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 0 0.33
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members Pathway Pathway_260 REACTOME_OPIOID_SIGNALLING 0 0.28
Category members GO Category GO:0006006 glucose metabolic process Database 0.28
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0006112 energy reserve metabolic process Database 0.21
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members Pathway Pathway_232 KEGG_LONG_TERM_POTENTIATION 0 0.21
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_948 BIOCARTA_CARM1_PATHWAY 0 0.17
Category members Pathway Pathway_233 KEGG_CALCIUM_SIGNALING_PATHWAY 0 0.13
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members Pathway Pathway_213 KEGG_GAP_JUNCTION 0 0.11
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Pathway Pathway_270 REACTOME_REGULATION_OF_INSULIN_SECRETION 0 0.09
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members Pathway Pathway_496 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS 0 0.07
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0050796 regulation of insulin secretion Database 0.06
Category members Pathway Pathway_236 BIOCARTA_MPR_PATHWAY 0 0.06
Category members Pathway Pathway_1138 BIOCARTA_STATHMIN_PATHWAY 0 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members Pathway Pathway_1151 KEGG_HEDGEHOG_SIGNALING_PATHWAY 0 0.04
Category members Pathway Pathway_251 REACTOME_DAG_AND_IP3_SIGNALING 0 0.02
Category members Pathway Pathway_1152 REACTOME_RAP1_SIGNALLING 0 0.01
Category members Pathway Pathway_160 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_235 BIOCARTA_PLCE_PATHWAY 0 0.01
Category members Pathway Pathway_1024 PID_INTEGRIN_A4B1_PATHWAY 0 0
Category members Pathway Pathway_1069 BIOCARTA_MCALPAIN_PATHWAY 0 0
Category members Pathway Pathway_1099 BIOCARTA_AKAP13_PATHWAY 0 0
Category members Pathway Pathway_1130 BIOCARTA_GATA3_PATHWAY 0 0
Category members Pathway Pathway_1153 BIOCARTA_AKAPCENTROSOME_PATHWAY 0 0
Category members Pathway Pathway_1154 BIOCARTA_SHH_PATHWAY 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_212 BIOCARTA_IGF1R_PATHWAY 0 0
Category members Pathway Pathway_218 BIOCARTA_GPCR_PATHWAY 0 0
Category members Pathway Pathway_222 REACTOME_CA_DEPENDENT_EVENTS 0 0
Category members Pathway Pathway_224 REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS 0 0
Category members Pathway Pathway_227 REACTOME_PLC_BETA_MEDIATED_EVENTS 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members Pathway Pathway_238 REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS 0 0
Category members Pathway Pathway_239 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB 0 0
Category members Pathway Pathway_241 BIOCARTA_CSK_PATHWAY 0 0
Category members Pathway Pathway_242 REACTOME_AQUAPORIN_MEDIATED_TRANSPORT 0 0
Category members Pathway Pathway_244 KEGG_MELANOGENESIS 0 0
Category members Pathway Pathway_245 BIOCARTA_CFTR_PATHWAY 0 0
Category members Pathway Pathway_246 REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION 0 0
Category members Pathway Pathway_248 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS 0 0
Category members Pathway Pathway_249 BIOCARTA_CREB_PATHWAY 0 0
Category members Pathway Pathway_250 BIOCARTA_BAD_PATHWAY 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_257 KEGG_GNRH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_261 REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Pathway Pathway_266 KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 0 0
Category members Pathway Pathway_268 KEGG_TASTE_TRANSDUCTION 0 0
Category members Pathway Pathway_271 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 0 0
Category members Pathway Pathway_301 BIOCARTA_NO1_PATHWAY 0 0
Category members Pathway Pathway_359 BIOCARTA_DREAM_PATHWAY 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_421 BIOCARTA_NOS1_PATHWAY 0 0
Category members Pathway Pathway_490 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_506 REACTOME_IL_3_5_AND_GM_CSF_SIGNALING 0 0
Category members Pathway Pathway_550 PID_IL3_PATHWAY 0 0
Category members Pathway Pathway_569 PID_GMCSF_PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_641 BIOCARTA_NFAT_PATHWAY 0 0
Category members Pathway Pathway_676 BIOCARTA_CK1_PATHWAY 0 0
Category members Pathway Pathway_702 BIOCARTA_VIP_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_879 BIOCARTA_AKAP95_PATHWAY 0 0
Category members Pathway Pathway_883 KEGG_PRION_DISEASES 0 0
Category members Pathway Pathway_993 BIOCARTA_AGPCR_PATHWAY 0 0
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0004691 cAMP-dependent protein kinase activity Database 0
Category members GO Category GO:0005952 cAMP-dependent protein kinase complex Database 0
Category members GO Category GO:0006833 water transport Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway Database 0
Category members GO Category GO:0007202 activation of phospholipase C activity Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0019433 triglyceride catabolic process Database 0
Category members GO Category GO:0034199 activation of protein kinase A activity Database 0
Category members GO Category GO:0051447 negative regulation of meiotic cell cycle Database 0
Category members GO Category GO:0071377 cellular response to glucagon stimulus Database 0


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