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Query: GNB2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GNB2 0 2.730 0.120 -0.090 0.137 0.627 1.296

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GNB2 Ubiquitylation K209 0.251 0.419 _TFVSGACDASIK(gl)LWDVR_
GNB2 Ubiquitylation K23 -0.095 0.033 _K(gl)ACGDSTLTQITAGLDPVGR_

Background Information for GNB2:


Pubmed-GNB2 »
Uniprot-GNB2 »
Biogrid-GNB2 »
ProteomicsDB-GNB2 »

Tumorportal-GNB2 »
COSMIC-GNB2 »
GenomeRNAi-GNB2 »
Genecards-GNB2


Protein-protein Interactions for GNB2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT4 Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait KCTD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB7A Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TMOD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait UFL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait USO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACSF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ADAM21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AKR7A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ANGPTL7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASB6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BMP7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C7orf52 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CBLN4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD97 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHIA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLU Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPLX3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CTSE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CYP8B1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEFB104A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXL14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FMO2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GALK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GDF9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNAI3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GRN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HMOX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR2C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IGFBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL27RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KCNJ5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MMP26 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NTRK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLA2G10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR3E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRAMEF17 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCMH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERINC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SHBG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC29A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC4A8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC6A5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SP6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCTN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TINAGL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM206 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMPRSS12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TXNDC9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF517 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GNB2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members G-protein_beta_WD-40_rep IPR020472 0.12
Category members Gprotein_B IPR001632 0
Category members Guanine_nucleotide-bd_bsu IPR016346 0


Protein complexes (CORUM database) featuring GNB2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 117 GPR56-CD81-Galphaq/11-Gbeta complex Database 0


Categories featuring GNB2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_1105 REACTOME_GPCR_LIGAND_BINDING 0 2.35
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_1104 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS 0 0.93
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members Pathway Pathway_263 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 0 0.49
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members Pathway Pathway_260 REACTOME_OPIOID_SIGNALLING 0 0.28
Category members Pathway Pathway_253 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 0 0.26
Category members Pathway Pathway_1102 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS 0 0.25
Category members Pathway Pathway_228 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS 0 0.24
Category members Pathway Pathway_760 REACTOME_POTASSIUM_CHANNELS 0 0.23
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0006112 energy reserve metabolic process Database 0.21
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_270 REACTOME_REGULATION_OF_INSULIN_SECRETION 0 0.09
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members Pathway Pathway_285 REACTOME_PLATELET_HOMEOSTASIS 0 0.08
Category members Pathway Pathway_721 REACTOME_SIGNAL_AMPLIFICATION 0 0.06
Category members Pathway Pathway_486 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 0 0.04
Category members Pathway Pathway_1100 REACTOME_G_PROTEIN_ACTIVATION 0 0
Category members Pathway Pathway_1101 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR 0 0
Category members Pathway Pathway_1103 REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR 0 0
Category members Pathway Pathway_1106 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 0 0
Category members Pathway Pathway_1107 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_215 REACTOME_GABA_RECEPTOR_ACTIVATION 0 0
Category members Pathway Pathway_219 REACTOME_GABA_B_RECEPTOR_ACTIVATION 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members Pathway Pathway_242 REACTOME_AQUAPORIN_MEDIATED_TRANSPORT 0 0
Category members Pathway Pathway_246 REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION 0 0
Category members Pathway Pathway_248 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_269 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE 0 0
Category members Pathway Pathway_271 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 0 0
Category members Pathway Pathway_487 REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 0 0
Category members Pathway Pathway_623 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 0 0
Category members Pathway Pathway_661 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA 0 0
Category members Pathway Pathway_664 REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING 0 0
Category members Pathway Pathway_675 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA 0 0
Category members Pathway Pathway_678 REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING 0 0
Category members Pathway Pathway_722 REACTOME_ADP_SIGNALLING_THROUGH_P2RY1 0 0
Category members Pathway Pathway_761 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS 0 0
Category members Pathway Pathway_994 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS 0 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005246 calcium channel regulator activity Database 0
Category members GO Category GO:0044297 cell body Database 0
Category members GO Category GO:0051020 GTPase binding Database 0
Category members GO Category GO:0071377 cellular response to glucagon stimulus Database 0


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