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Query: CALM2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CALM2 1 -0.209 -0.690 0.700 1.911
CALM2 1 -0.209 -0.690 0.700 0.877 -4.680

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CALM2 Ubiquitylation K142 0.922 _VFDK(gl)DGNGYISAAELR_
CALM2 Ubiquitylation K78 0.061 _DGDGTITTK(gl)ELGTVMR_

Background Information for CALM2:


Pubmed-CALM2 »
Uniprot-CALM2 »
Biogrid-CALM2 »
ProteomicsDB-CALM2 »

Tumorportal-CALM2 »
COSMIC-CALM2 »
GenomeRNAi-CALM2 »
Genecards-CALM2


Protein-protein Interactions for CALM2
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in CALM2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EF_hand_dom IPR002048 0
Category members EF-hand_Ca_insen IPR014837 0


Protein complexes (CORUM database) featuring CALM2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1223 H2AX complex, isolated from cells without IR exposure Database 8.51
Category members Corum 2242 TGM2-HD-CALM1 complex Database 0
Category members Corum 4158 HSP90-FKBP38-CAM-Ca(2+) complex Database 0
Category members Corum 5189 YWHAQ-CALM1-CABIN1 complex Database 0
Category members Corum 5526 CALM1-FKBP38-BCL2 complex Database 0


Categories featuring CALM2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:24055347 Jungmichel et al., 2013 UV-stimulated poly(ADP-Ribosyl)ation targets Jungmichel et al., 2013 INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members Pathway Pathway_35 REACTOME_GLUCOSE_METABOLISM 0 1.79
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members Pathway Pathway_267 KEGG_OLFACTORY_TRANSDUCTION 0 0.75
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0005876 spindle microtubule Database 0.68
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members Pathway Pathway_305 REACTOME_DARPP_32_EVENTS 0 0.47
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_214 REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 0 0.33
Category members GO Category GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity Database 0.33
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members Pathway Pathway_260 REACTOME_OPIOID_SIGNALLING 0 0.28
Category members GO Category GO:0006006 glucose metabolic process Database 0.28
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0007603 phototransduction, visible light Database 0.25
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members Pathway Pathway_66 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS 0 0.22
Category members GO Category GO:0034704 calcium channel complex Database 0.21
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members Pathway Pathway_232 KEGG_LONG_TERM_POTENTIATION 0 0.21
Category members GO Category GO:0005980 glycogen catabolic process Database 0.2
Category members GO Category GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity Database 0.19
Category members GO Category GO:0048306 calcium-dependent protein binding Database 0.17
Category members Pathway Pathway_686 BIOCARTA_BCR_PATHWAY 0 0.16
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_233 KEGG_CALCIUM_SIGNALING_PATHWAY 0 0.13
Category members GO Category GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Database 0.12
Category members Pathway Pathway_698 BIOCARTA_CALCINEURIN_PATHWAY 0 0.11
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0005513 detection of calcium ion Database 0.1
Category members Pathway Pathway_297 BIOCARTA_NDKDYNAMIN_PATHWAY 0 0.08
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0030017 sarcomere Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0032465 regulation of cytokinesis Database 0.05
Category members GO Category GO:0016056 rhodopsin mediated signaling pathway Database 0.04
Category members Pathway Pathway_543 BIOCARTA_TCR_PATHWAY 0 0.03
Category members Pathway Pathway_690 BIOCARTA_CCR5_PATHWAY 0 0.03
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members Pathway Pathway_251 REACTOME_DAG_AND_IP3_SIGNALING 0 0.02
Category members Pathway Pathway_160 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0 0.01
Category members GO Category GO:0022400 regulation of rhodopsin mediated signaling pathway Database 0
Category members Pathway Pathway_1119 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR 0 0
Category members Pathway Pathway_1144 BIOCARTA_MEF2D_PATHWAY 0 0
Category members Pathway Pathway_1167 BIOCARTA_CACAM_PATHWAY 0 0
Category members Pathway Pathway_1169 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII 0 0
Category members Pathway Pathway_1190 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_218 BIOCARTA_GPCR_PATHWAY 0 0
Category members Pathway Pathway_222 REACTOME_CA_DEPENDENT_EVENTS 0 0
Category members Pathway Pathway_224 REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS 0 0
Category members Pathway Pathway_227 REACTOME_PLC_BETA_MEDIATED_EVENTS 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members Pathway Pathway_238 REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS 0 0
Category members Pathway Pathway_244 KEGG_MELANOGENESIS 0 0
Category members Pathway Pathway_257 KEGG_GNRH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_261 REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_301 BIOCARTA_NO1_PATHWAY 0 0
Category members Pathway Pathway_421 BIOCARTA_NOS1_PATHWAY 0 0
Category members Pathway Pathway_435 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION 0 0
Category members Pathway Pathway_438 REACTOME_ENOS_ACTIVATION_AND_REGULATION 0 0
Category members Pathway Pathway_439 BIOCARTA_GCR_PATHWAY 0 0
Category members Pathway Pathway_488 KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 0 0
Category members Pathway Pathway_524 BIOCARTA_FMLP_PATHWAY 0 0
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_574 BIOCARTA_HDAC_PATHWAY 0 0
Category members Pathway Pathway_597 BIOCARTA_FCER1_PATHWAY 0 0
Category members Pathway Pathway_641 BIOCARTA_NFAT_PATHWAY 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members Pathway Pathway_659 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS 0 0
Category members Pathway Pathway_678 REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING 0 0
Category members Pathway Pathway_693 BIOCARTA_PYK2_PATHWAY 0 0
Category members Pathway Pathway_702 BIOCARTA_VIP_PATHWAY 0 0
Category members Pathway Pathway_704 BIOCARTA_BIOPEPTIDES_PATHWAY 0 0
Category members Pathway Pathway_935 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS 0 0
Category members Pathway Pathway_938 BIOCARTA_PGC1A_PATHWAY 0 0
Category members Pathway Pathway_949 REACTOME_SMOOTH_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_950 REACTOME_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_998 BIOCARTA_AT1R_PATHWAY 0 0
Category members Disease phenotype VENTRICULAR_TACHYCARDIA_CATECHOLAMINERGIC_POLYMORPHIC_4 VENTRICULAR TACHYCARDIA CATECHOLAMINERGIC POLYMORPHIC 4 Database 0
Category members GO Category GO:0001975 response to amphetamine Database 0
Category members GO Category GO:0002027 regulation of heart rate Database 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0006936 muscle contraction Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007202 activation of phospholipase C activity Database 0
Category members GO Category GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Database 0
Category members GO Category GO:0030801 positive regulation of cyclic nucleotide metabolic process Database 0
Category members GO Category GO:0031432 titin binding Database 0
Category members GO Category GO:0031996 thioesterase binding Database 0
Category members GO Category GO:0031997 N-terminal myristoylation domain binding Database 0
Category members GO Category GO:0032516 positive regulation of phosphoprotein phosphatase activity Database 0
Category members GO Category GO:0035307 positive regulation of protein dephosphorylation Database 0
Category members GO Category GO:0043274 phospholipase binding Database 0
Category members GO Category GO:0043548 phosphatidylinositol 3-kinase binding Database 0
Category members GO Category GO:0043647 inositol phosphate metabolic process Database 0
Category members GO Category GO:0046209 nitric oxide metabolic process Database 0
Category members GO Category GO:0050999 regulation of nitric-oxide synthase activity Database 0
Category members GO Category GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity Database 0
Category members GO Category GO:0051412 response to corticosterone Database 0
Category members GO Category GO:0051592 response to calcium ion Database 0
Category members GO Category GO:0055117 regulation of cardiac muscle contraction Database 0


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