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Query: ACTA1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ACTA1 0 -0.164 -0.170 0.010 -0.189 0.025 -0.002 -0.165
ACTA1 0 -0.164 -0.170 0.010 0.157

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for ACTA1:


Pubmed-ACTA1 »
Uniprot-ACTA1 »
Biogrid-ACTA1 »
ProteomicsDB-ACTA1 »

Tumorportal-ACTA1 »
COSMIC-ACTA1 »
GenomeRNAi-ACTA1 »
Genecards-ACTA1


Protein-protein Interactions for ACTA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANXA8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DMC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIF1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCSTN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1R1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TLE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF324B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ACTA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Actin-related IPR004000 0.11


Protein complexes (CORUM database) featuring ACTA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ACTA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members GO Category GO:0070062 extracellular vesicular exosome Database 1.36
Category members Pathway Pathway_1156 BIOCARTA_UCALPAIN_PATHWAY 0 1.12
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0043531 ADP binding Database 0.27
Category members GO Category GO:0009612 response to mechanical stimulus Database 0.23
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members Pathway Pathway_1273 BIOCARTA_RAB_PATHWAY 0 0.18
Category members Pathway Pathway_1041 BIOCARTA_AGR_PATHWAY 0 0.13
Category members GO Category GO:0048545 response to steroid hormone Database 0.11
Category members Pathway Pathway_1158 BIOCARTA_EPHA4_PATHWAY 0 0.08
Category members GO Category GO:0005884 actin filament Database 0.08
Category members Pathway Pathway_236 BIOCARTA_MPR_PATHWAY 0 0.06
Category members GO Category GO:0030017 sarcomere Database 0.06
Category members Pathway Pathway_653 BIOCARTA_MET_PATHWAY 0 0.04
Category members Disease phenotype Congenital_fiber-type_disproportion_myopathy Congenital fiber-type disproportion myopathy Database 0.04
Category members GO Category GO:0001725 stress fiber Database 0.04
Category members Pathway Pathway_1017 BIOCARTA_HSP27_PATHWAY 0 0
Category members Pathway Pathway_1037 BIOCARTA_SALMONELLA_PATHWAY 0 0
Category members Pathway Pathway_1040 BIOCARTA_MAL_PATHWAY 0 0
Category members Pathway Pathway_1069 BIOCARTA_MCALPAIN_PATHWAY 0 0
Category members Pathway Pathway_301 BIOCARTA_NO1_PATHWAY 0 0
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Pathway Pathway_641 BIOCARTA_NFAT_PATHWAY 0 0
Category members Pathway Pathway_668 PID_RHOA_PATHWAY 0 0
Category members Pathway Pathway_912 BIOCARTA_ACTINY_PATHWAY 0 0
Category members Disease phenotype Childhood-onset_nemaline_myopathy Childhood-onset nemaline myopathy Database 0
Category members Disease phenotype Intermediate_nemaline_myopathy Intermediate nemaline myopathy Database 0
Category members Disease phenotype MYOPATHY_CONGENITAL_WITH_FIBER-TYPE_DISPROPORTION MYOPATHY CONGENITAL WITH FIBER-TYPE DISPROPORTION Database 0
Category members Disease phenotype Severe_congenital_nemaline_myopathy Severe congenital nemaline myopathy Database 0
Category members Disease phenotype Typical_nemaline_myopathy Typical nemaline myopathy Database 0
Category members GO Category GO:0005200 structural constituent of cytoskeleton Database 0
Category members GO Category GO:0005865 striated muscle thin filament Database 0
Category members GO Category GO:0006936 muscle contraction Database 0
Category members GO Category GO:0009991 response to extracellular stimulus Database 0
Category members GO Category GO:0010226 response to lithium ion Database 0
Category members GO Category GO:0016049 cell growth Database 0
Category members GO Category GO:0017022 myosin binding Database 0
Category members GO Category GO:0030049 muscle filament sliding Database 0
Category members GO Category GO:0030240 skeletal muscle thin filament assembly Database 0
Category members GO Category GO:0048741 skeletal muscle fiber development Database 0


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