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Query: ITGA1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ITGA1 0 2.199 -0.750 1.480 0.650 0.069

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for ITGA1:


Pubmed-ITGA1 »
Uniprot-ITGA1 »
Biogrid-ITGA1 »
ProteomicsDB-ITGA1 »

Tumorportal-ITGA1 »
COSMIC-ITGA1 »
GenomeRNAi-ITGA1 »
Genecards-ITGA1


Protein-protein Interactions for ITGA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CSNK1D Cat. description Hein, Mann, Cell 2015
Category members IP bait FAM178A Cat. description Hein, Mann, Cell 2015
Category members IP bait GNPNAT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HAX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAGOH;MAGOHB Cat. description Hein, Mann, Cell 2015
Category members IP bait LGALS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LMAN2L Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ITGA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members FG-GAP IPR013517 0.3
Category members Int_alpha_beta-p IPR013519 0.1
Category members Integrin_alpha IPR000413 0.03
Category members Integrin_alpha-2 IPR013649 0.03
Category members VWF_A IPR002035 0


Protein complexes (CORUM database) featuring ITGA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2434 ITGA1-ITGB1-COL6A3 complex Database 0.09
Category members Corum 2435 ITGA1-ITGB1-PTPN2 complex Database 0


Categories featuring ITGA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_1156 BIOCARTA_UCALPAIN_PATHWAY 0 1.12
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members Pathway Pathway_295 PID_ARF6_TRAFFICKING_PATHWAY 0 0.9
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members GO Category GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway Database 0.64
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_449 KEGG_HEMATOPOIETIC_CELL_LINEAGE 0 0.31
Category members GO Category GO:0042311 vasodilation Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members Pathway Pathway_1135 PID_PRL_SIGNALING_EVENTS_PATHWAY 0 0.27
Category members Pathway Pathway_536 BIOCARTA_ECM_PATHWAY 0 0.25
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_1041 BIOCARTA_AGR_PATHWAY 0 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0005178 integrin binding Database 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_1158 BIOCARTA_EPHA4_PATHWAY 0 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members Pathway Pathway_680 BIOCARTA_SPPA_PATHWAY 0 0.05
Category members GO Category GO:0043204 perikaryon Database 0.05
Category members Pathway Pathway_653 BIOCARTA_MET_PATHWAY 0 0.04
Category members Pathway Pathway_1284 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS 0 0.04
Category members GO Category GO:0008305 integrin complex Database 0.03
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members GO Category GO:0005518 collagen binding Database 0.02
Category members GO Category GO:0009897 external side of plasma membrane Database 0
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_1027 PID_INTEGRIN1_PATHWAY 0 0
Category members Pathway Pathway_1069 BIOCARTA_MCALPAIN_PATHWAY 0 0
Category members Pathway Pathway_1286 PID_INTEGRIN_CS_PATHWAY 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Pathway Pathway_539 PID_LYMPH_ANGIOGENESIS_PATHWAY 0 0
Category members Pathway Pathway_544 BIOCARTA_BCELLSURVIVAL_PATHWAY 0 0
Category members Pathway Pathway_593 PID_TCPTP_PATHWAY 0 0
Category members Pathway Pathway_922 KEGG_ECM_RECEPTOR_INTERACTION 0 0
Category members Pathway Pathway_930 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 0 0
Category members Pathway Pathway_949 REACTOME_SMOOTH_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_950 REACTOME_MUSCLE_CONTRACTION 0 0
Category members GO Category GO:0000187 activation of MAPK activity Database 0
Category members GO Category GO:0001669 acrosomal vesicle Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0006936 muscle contraction Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007160 cell-matrix adhesion Database 0
Category members GO Category GO:0007229 integrin-mediated signaling pathway Database 0
Category members GO Category GO:0030593 neutrophil chemotaxis Database 0
Category members GO Category GO:0032516 positive regulation of phosphoprotein phosphatase activity Database 0
Category members GO Category GO:0043525 positive regulation of neuron apoptotic process Database 0
Category members GO Category GO:0045123 cellular extravasation Database 0
Category members GO Category GO:0045178 basal part of cell Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048812 neuron projection morphogenesis Database 0
Category members GO Category GO:0060326 cell chemotaxis Database 0


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