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Query: EZR

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EZR 1 0.159 -0.240 -0.210 2.501 -2.209 0.246 0.091

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EZR Ubiquitylation K162 1.580 0.660 _VMDQHK(gl)LTR_
EZR Ubiquitylation K139 1.519 0.361 _FGDYNK(gl)EVHK_
EZR Ubiquitylation K344 0.598 0.235 _EK(gl)EELMLR_
EZR Ubiquitylation K450 0.393 0.174 _AK(gl)EAQDDLVK_
EZR Ubiquitylation K79 0.172 -0.032 _ENPLQFK(gl)FR_
EZR Ubiquitylation K3 -0.313 -0.251 _PK(gl)PINVR_
EZR Ubiquitylation K253 -0.069 _NISFNDK(gl)K_
EZR Ubiquitylation K263 -0.786 _K(gl)APDFVFYAPR_
EZR Ubiquitylation K357 -0.003 _LQDYEEK(gl)TK_
EZR Ubiquitylation K359 0.051 _LQDYEEK(gl)TK_

Background Information for EZR:


Pubmed-EZR »
Uniprot-EZR »
Biogrid-EZR »
ProteomicsDB-EZR »

Tumorportal-EZR »
COSMIC-EZR »
GenomeRNAi-EZR »
Genecards-EZR


Protein-protein Interactions for EZR
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EZR Cat. description Hein, Mann, Cell 2015
Category members IP bait MSN Cat. description Hein, Mann, Cell 2015
Category members IP bait C19orf21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSPAN33 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EZR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members Ez/rad/moesin_like IPR000798 0.38
Category members FERM_N IPR018979 0.36
Category members FERM_PH-like_C IPR018980 0.35
Category members Band_41_fam IPR019750 0.33
Category members FERM_domain IPR000299 0
Category members Moesin_tail IPR008954 0
Category members ERM IPR011174 0
Category members ERM_C_dom IPR011259 0
Category members FERM_central IPR019748 0
Category members Band_41_domain IPR019749 0


Protein complexes (CORUM database) featuring EZR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 681 (C-CFTR)2-NHERF-ezrin complex Database 0
Category members Corum 682 C-CFTR-NHERF(PDZ1 domain)-ezrin complex Database 0
Category members Corum 683 C-CFTR-NHERF(PDZ2 domain)-ezrin complex Database 0


Categories featuring EZR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003779 actin binding Database 5.41
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_1156 BIOCARTA_UCALPAIN_PATHWAY 0 1.12
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members GO Category GO:0007016 cytoskeletal anchoring at plasma membrane Database 0.74
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0032587 ruffle membrane Database 0.65
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members GO Category GO:0008092 cytoskeletal protein binding Database 0.5
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0051017 actin filament bundle assembly Database 0.47
Category members Pathway Pathway_1026 KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 0 0.45
Category members GO Category GO:0001726 ruffle Database 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0030855 epithelial cell differentiation Database 0.28
Category members GO Category GO:0030863 cortical cytoskeleton Database 0.24
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members GO Category GO:0005902 microvillus Database 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_1022 PID_SYNDECAN_2_PATHWAY 0 0.08
Category members GO Category GO:0005884 actin filament Database 0.08
Category members GO Category GO:0030175 filopodium Database 0.05
Category members Pathway Pathway_1136 REACTOME_RECYCLING_PATHWAY_OF_L1 0 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0031623 receptor internalization Database 0.02
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members Pathway Pathway_1069 BIOCARTA_MCALPAIN_PATHWAY 0 0
Category members Pathway Pathway_245 BIOCARTA_CFTR_PATHWAY 0 0
Category members Pathway Pathway_650 PID_FAS_PATHWAY 0 0
Category members Pathway Pathway_668 PID_RHOA_PATHWAY 0 0
Category members Pathway Pathway_692 REACTOME_NETRIN1_SIGNALING 0 0
Category members GO Category GO:0001931 uropod Database 0
Category members GO Category GO:0005932 microtubule basal body Database 0
Category members GO Category GO:0007159 leukocyte cell-cell adhesion Database 0
Category members GO Category GO:0008360 regulation of cell shape Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0019898 extrinsic to membrane Database 0
Category members GO Category GO:0022614 membrane to membrane docking Database 0
Category members GO Category GO:0030315 T-tubule Database 0
Category members GO Category GO:0031528 microvillus membrane Database 0
Category members GO Category GO:0035088 establishment or maintenance of apical/basal cell polarity Database 0
Category members GO Category GO:0044297 cell body Database 0
Category members GO Category GO:0045177 apical part of cell Database 0
Category members GO Category GO:0046847 filopodium assembly Database 0
Category members GO Category GO:0050839 cell adhesion molecule binding Database 0
Category members GO Category GO:0051286 cell tip Database 0


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