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Query: CAPN1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CAPN1 0 2.822 0.770 -1.250
CAPN1 0 2.822 0.770 -1.250 0.308 0.573 0.029

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CAPN1 Ubiquitylation K79 1.041 _DLGPNSSK(gl)TYGIK_
CAPN1 Ubiquitylation K359 0.871 0.535 _LEICNLTPDALK(gl)SR_
CAPN1 Ubiquitylation K280 0.470 _GHAYSVTGAK(gl)QVNYR_

Background Information for CAPN1:


Pubmed-CAPN1 »
Uniprot-CAPN1 »
Biogrid-CAPN1 »
ProteomicsDB-CAPN1 »

Tumorportal-CAPN1 »
COSMIC-CAPN1 »
GenomeRNAi-CAPN1 »
Genecards-CAPN1


Protein-protein Interactions for CAPN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CAPN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KATNA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SNRNP70 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPN8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KNG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBC1D22B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZIC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CAPN1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Peptidase_C2_calpain_cat IPR001300 0
Category members EF_hand_dom IPR002048 0
Category members Calpain_domain_III IPR022682 0
Category members Calpain_III IPR022683 0
Category members Calpain_cysteine_protease IPR022684 0


Protein complexes (CORUM database) featuring CAPN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CAPN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_1156 BIOCARTA_UCALPAIN_PATHWAY 0 1.12
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_1141 BIOCARTA_P35ALZHEIMERS_PATHWAY 0 0.19
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Pathway Pathway_1069 BIOCARTA_MCALPAIN_PATHWAY 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_602 PID_PTP1B_PATHWAY 0 0
Category members GO Category GO:0004198 calcium-dependent cysteine-type endopeptidase activity Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0032801 receptor catabolic process Database 0


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