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Query: TWIST1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TWIST1 0 0.974 -0.640 1.150

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TWIST1 Ubiquitylation K150 -0.176 _IQTLK(gl)LAAR_

Background Information for TWIST1:


Pubmed-TWIST1 »
Uniprot-TWIST1 »
Biogrid-TWIST1 »
ProteomicsDB-TWIST1 »

Tumorportal-TWIST1 »
COSMIC-TWIST1 »
GenomeRNAi-TWIST1 »
Genecards-TWIST1


Protein-protein Interactions for TWIST1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CETN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TWIST1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members bHLH_dom IPR011598 0.32


Protein complexes (CORUM database) featuring TWIST1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TWIST1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0050679 positive regulation of epithelial cell proliferation Database 0.5
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0045668 negative regulation of osteoblast differentiation Database 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0060021 palate development Database 0.23
Category members Pathway Pathway_762 PID_HIF2PATHWAY 0 0.23
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0045766 positive regulation of angiogenesis Database 0.19
Category members GO Category GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity Database 0.18
Category members GO Category GO:0010718 positive regulation of epithelial to mesenchymal transition Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_347 BIOCARTA_ARF_PATHWAY 0 0.12
Category members GO Category GO:0042476 odontogenesis Database 0.09
Category members GO Category GO:0035067 negative regulation of histone acetylation Database 0.08
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members GO Category GO:0003180 aortic valve morphogenesis Database 0.05
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0048701 embryonic cranial skeleton morphogenesis Database 0.01
Category members GO Category GO:0048704 embryonic skeletal system morphogenesis Database 0
Category members Pathway Pathway_119 PID_HES_HEY_PATHWAY 0 0
Category members Disease phenotype Isolated_brachycephaly Isolated brachycephaly Database 0
Category members Disease phenotype Isolated_scaphocephaly Isolated scaphocephaly Database 0
Category members Disease phenotype SAETHRE-CHOTZEN_SYNDROME SAETHRE-CHOTZEN SYNDROME Database 0
Category members GO Category GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity Database 0
Category members GO Category GO:0001503 ossification Database 0
Category members GO Category GO:0001649 osteoblast differentiation Database 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0003183 mitral valve morphogenesis Database 0
Category members GO Category GO:0003203 endocardial cushion morphogenesis Database 0
Category members GO Category GO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis Database 0
Category members GO Category GO:0007517 muscle organ development Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling Database 0
Category members GO Category GO:0030326 embryonic limb morphogenesis Database 0
Category members GO Category GO:0030500 regulation of bone mineralization Database 0
Category members GO Category GO:0032000 positive regulation of fatty acid beta-oxidation Database 0
Category members GO Category GO:0032720 negative regulation of tumor necrosis factor production Database 0
Category members GO Category GO:0032760 positive regulation of tumor necrosis factor production Database 0
Category members GO Category GO:0033128 negative regulation of histone phosphorylation Database 0
Category members GO Category GO:0035115 embryonic forelimb morphogenesis Database 0
Category members GO Category GO:0035116 embryonic hindlimb morphogenesis Database 0
Category members GO Category GO:0035137 hindlimb morphogenesis Database 0
Category members GO Category GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway Database 0
Category members GO Category GO:0042473 outer ear morphogenesis Database 0
Category members GO Category GO:0042733 embryonic digit morphogenesis Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043425 bHLH transcription factor binding Database 0
Category members GO Category GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator Database 0
Category members GO Category GO:0044092 negative regulation of molecular function Database 0
Category members GO Category GO:0045596 negative regulation of cell differentiation Database 0
Category members GO Category GO:0045843 negative regulation of striated muscle tissue development Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0048642 negative regulation of skeletal muscle tissue development Database 0
Category members GO Category GO:0060348 bone development Database 0
Category members GO Category GO:0060363 cranial suture morphogenesis Database 0
Category members GO Category GO:0060900 embryonic camera-type eye formation Database 0
Category members GO Category GO:0061029 eyelid development in camera-type eye Database 0
Category members GO Category GO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis Database 0
Category members GO Category GO:0070888 E-box binding Database 0
Category members GO Category GO:0071363 cellular response to growth factor stimulus Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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