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Query: GLI3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GLI3 0 0.816 -0.980 1.650

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GLI3 Phosphorylation S664 -0.582 -0.252 _S(ph)PGRPTQGALGEQQDLSNTTSK_

Background Information for GLI3:


Pubmed-GLI3 »
Uniprot-GLI3 »
Biogrid-GLI3 »
ProteomicsDB-GLI3 »

Tumorportal-GLI3 »
COSMIC-GLI3 »
GenomeRNAi-GLI3 »
Genecards-GLI3


Protein-protein Interactions for GLI3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CELA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RCCD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait THSD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GLI3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_C2H2-like IPR015880 1.29
Category members Znf_C2H2 IPR007087 0.92


Protein complexes (CORUM database) featuring GLI3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring GLI3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0007224 smoothened signaling pathway Database 2.11
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0016485 protein processing Database 0.57
Category members GO Category GO:0016592 mediator complex Database 0.53
Category members GO Category GO:0048589 developmental growth Database 0.45
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0043627 response to estrogen Database 0.4
Category members GO Category GO:0030324 lung development Database 0.39
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members GO Category GO:0048856 anatomical structure development Database 0.33
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0048566 embryonic digestive tract development Database 0.24
Category members GO Category GO:0060021 palate development Database 0.23
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0007389 pattern specification process Database 0.18
Category members GO Category GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification Database 0.18
Category members GO Category GO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0043585 nose morphogenesis Database 0.18
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0070242 thymocyte apoptotic process Database 0.13
Category members GO Category GO:0021631 optic nerve morphogenesis Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_984 PID_HEDGEHOG_GLI_PATHWAY 0 0.1
Category members GO Category GO:0021861 forebrain radial glial cell differentiation Database 0.1
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0009952 anterior/posterior pattern specification Database 0.06
Category members GO Category GO:0043010 camera-type eye development Database 0.05
Category members GO Category GO:0045665 negative regulation of neuron differentiation Database 0.04
Category members GO Category GO:0009954 proximal/distal pattern formation Database 0.04
Category members GO Category GO:0021801 cerebral cortex radial glia guided migration Database 0.04
Category members GO Category GO:0035295 tube development Database 0.04
Category members GO Category GO:0061005 cell differentiation involved in kidney development Database 0.04
Category members Pathway Pathway_1151 KEGG_HEDGEHOG_SIGNALING_PATHWAY 0 0.04
Category members GO Category GO:0048557 embryonic digestive tract morphogenesis Database 0.04
Category members GO Category GO:0048646 anatomical structure formation involved in morphogenesis Database 0.04
Category members GO Category GO:0033077 T cell differentiation in thymus Database 0.03
Category members GO Category GO:0021915 neural tube development Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0048663 neuron fate commitment Database 0.02
Category members GO Category GO:0001656 metanephros development Database 0
Category members GO Category GO:0048704 embryonic skeletal system morphogenesis Database 0
Category members Pathway Pathway_1154 BIOCARTA_SHH_PATHWAY 0 0
Category members Pathway Pathway_1163 KEGG_BASAL_CELL_CARCINOMA 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Disease phenotype Acrocallosal_syndrome Acrocallosal syndrome Database 0
Category members Disease phenotype PALLISTER-HALL_SYNDROME PALLISTER-HALL SYNDROME Database 0
Category members Disease phenotype Postaxial_polydactyly_type_A_bilateral Postaxial polydactyly type A bilateral Database 0
Category members GO Category GO:0001658 branching involved in ureteric bud morphogenesis Database 0
Category members GO Category GO:0001822 kidney development Database 0
Category members GO Category GO:0002052 positive regulation of neuroblast proliferation Database 0
Category members GO Category GO:0005929 cilium Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007417 central nervous system development Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0007442 hindgut morphogenesis Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0009953 dorsal/ventral pattern formation Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0021513 spinal cord dorsal/ventral patterning Database 0
Category members GO Category GO:0021522 spinal cord motor neuron differentiation Database 0
Category members GO Category GO:0021537 telencephalon development Database 0
Category members GO Category GO:0021543 pallium development Database 0
Category members GO Category GO:0021544 subpallium development Database 0
Category members GO Category GO:0021798 forebrain dorsal/ventral pattern formation Database 0
Category members GO Category GO:0030318 melanocyte differentiation Database 0
Category members GO Category GO:0030326 embryonic limb morphogenesis Database 0
Category members GO Category GO:0030879 mammary gland development Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0032332 positive regulation of chondrocyte differentiation Database 0
Category members GO Category GO:0035035 histone acetyltransferase binding Database 0
Category members GO Category GO:0035108 limb morphogenesis Database 0
Category members GO Category GO:0042060 wound healing Database 0
Category members GO Category GO:0042307 positive regulation of protein import into nucleus Database 0
Category members GO Category GO:0042475 odontogenesis of dentin-containing tooth Database 0
Category members GO Category GO:0042733 embryonic digit morphogenesis Database 0
Category members GO Category GO:0043586 tongue development Database 0
Category members GO Category GO:0045060 negative thymic T cell selection Database 0
Category members GO Category GO:0045595 regulation of cell differentiation Database 0
Category members GO Category GO:0045596 negative regulation of cell differentiation Database 0
Category members GO Category GO:0045669 positive regulation of osteoblast differentiation Database 0
Category members GO Category GO:0045879 negative regulation of smoothened signaling pathway Database 0
Category members GO Category GO:0046638 positive regulation of alpha-beta T cell differentiation Database 0
Category members GO Category GO:0046639 negative regulation of alpha-beta T cell differentiation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048593 camera-type eye morphogenesis Database 0
Category members GO Category GO:0048598 embryonic morphogenesis Database 0
Category members GO Category GO:0048709 oligodendrocyte differentiation Database 0
Category members GO Category GO:0048754 branching morphogenesis of an epithelial tube Database 0
Category members GO Category GO:0048839 inner ear development Database 0
Category members GO Category GO:0060173 limb development Database 0
Category members GO Category GO:0060364 frontal suture morphogenesis Database 0
Category members GO Category GO:0060594 mammary gland specification Database 0
Category members GO Category GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning Database 0
Category members GO Category GO:0060840 artery development Database 0


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