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Query: RRM2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RRM2 1 0.329

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RRM2 Ubiquitylation K106 -0.247 _VLASK(gl)TAR_
RRM2 Phosphorylation T93 -1.284 -0.534 _GLSLVDKENT(ph)PPALSGTR_
RRM2 Ubiquitylation K424 2.394 -0.588 _TNFFEK(gl)R_
RRM2 Ubiquitylation K121 -2.427 -0.884 _TK(gl)AAAPGVEDEPLLR_
RRM2 Phosphorylation S80 -1.483 -1.780 _VPLAPITDPQQLQLS(ph)PLK_

Background Information for RRM2:


Pubmed-RRM2 »
Uniprot-RRM2 »
Biogrid-RRM2 »
ProteomicsDB-RRM2 »

Tumorportal-RRM2 »
COSMIC-RRM2 »
GenomeRNAi-RRM2 »
Genecards-RRM2


Protein-protein Interactions for RRM2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANAPC15 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANAPC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC16 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC23 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC26 Cat. description Hein, Mann, Cell 2015
Category members IP bait SDHAF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMEM248 Cat. description Hein, Mann, Cell 2015
Category members IP bait FAF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRM2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RRM2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RNR_small IPR000358 0
Category members Ferritin-like_SF IPR009078 0


Protein complexes (CORUM database) featuring RRM2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring RRM2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members Pathway Pathway_326 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION 0 0.49
Category members Pathway Pathway_332 REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 0 0.36
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Database 0.34
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members GO Category GO:0051290 protein heterotetramerization Database 0.05
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members Pathway Pathway_27 KEGG_GLUTATHIONE_METABOLISM 0 0
Category members Pathway Pathway_274 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES 0 0
Category members GO Category GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Database 0
Category members GO Category GO:0009186 deoxyribonucleoside diphosphate metabolic process Database 0
Category members GO Category GO:0009263 deoxyribonucleotide biosynthetic process Database 0
Category members GO Category GO:0015949 nucleobase-containing small molecule interconversion Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051259 protein oligomerization Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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