bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: CCNE1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CCNE1 0 -0.060 0.460 -0.980

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CCNE1 Phosphorylation S100 -0.765 _IIAPS(ph)RGSPLPVLSWANR_
CCNE1 Phosphorylation S103 -0.765 _IIAPS(ph)RGSPLPVLSWANR_
CCNE1 Phosphorylation S387 0.705 -0.922 _AS(ph)PLPSGLLTPPQSGK_

Background Information for CCNE1:


Pubmed-CCNE1 »
Uniprot-CCNE1 »
Biogrid-CCNE1 »
ProteomicsDB-CCNE1 »

Tumorportal-CCNE1 »
COSMIC-CCNE1 »
GenomeRNAi-CCNE1 »
Genecards-CCNE1


Protein-protein Interactions for CCNE1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CKS1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CKS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCNA Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CCNE1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cyclin_A/B/D/E/F IPR014400 0.09
Category members Cyclin_C-dom IPR004367 0
Category members Cyclin_N IPR006671 0
Category members Cyclin-like IPR013763 0


Protein complexes (CORUM database) featuring CCNE1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3015 p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex Database 0.28
Category members Corum 5159 E2F4-p107-cyclinE complex Database 0.02
Category members Corum 1656 p27-cyclinE-CDK2 complex Database 0
Category members Corum 5560 CDK2-CCNE1 complex Database 0


Categories featuring CCNE1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members GO Category GO:0030521 androgen receptor signaling pathway Database 1.25
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0051301 cell division Database 1.15
Category members Pathway Pathway_830 REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE 0 0.93
Category members Pathway Pathway_968 PID_FOXM1_PATHWAY 0 0.8
Category members Pathway Pathway_782 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 0 0.66
Category members Pathway Pathway_835 REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 0 0.63
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0006270 DNA replication initiation Database 0.57
Category members Pathway Pathway_326 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION 0 0.49
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_332 REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 0 0.36
Category members GO Category GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Database 0.34
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members Pathway Pathway_1135 PID_PRL_SIGNALING_EVENTS_PATHWAY 0 0.27
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members Pathway Pathway_871 BIOCARTA_P53_PATHWAY 0 0.19
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity Database 0.13
Category members GO Category GO:0050681 androgen receptor binding Database 0.12
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members Pathway Pathway_1171 SA_REG_CASCADE_OF_CYCLIN_EXPR 0 0.1
Category members Pathway Pathway_867 BIOCARTA_MCM_PATHWAY 0 0.1
Category members Pathway Pathway_973 BIOCARTA_P27_PATHWAY 0 0.1
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_1250 BIOCARTA_SKP2E2F_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_589 BIOCARTA_RACCYCD_PATHWAY 0 0
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0
Category members Pathway Pathway_869 REACTOME_G0_AND_EARLY_G1 0 0
Category members Pathway Pathway_970 BIOCARTA_CELLCYCLE_PATHWAY 0 0
Category members GO Category GO:0000307 cyclin-dependent protein kinase holoenzyme complex Database 0
Category members GO Category GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity Database 0


.

© Copyright Svejstrup Laboratory 2015