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Query: CCND2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CCND2 1 1.597 1.210 -0.610

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CCND2 Phosphorylation S271 2.155 _DGSKS(ph)EDELDQASTPTDVR_
CCND2 Ubiquitylation K173 -1.137 0.202 _EK(gl)LSLIR_
CCND2 Phosphorylation S269 0.049 _DGS(ph)KSEDELDQASTPTDVR_
CCND2 Ubiquitylation K45 -0.759 -0.277 _YLPQCSYFK(gl)CVQK_
CCND2 Ubiquitylation K49 -0.524 _CVQK(gl)DIQPYMR_
CCND2 Ubiquitylation K113 -0.572 _LK(gl)ETSPLTAEK_

Background Information for CCND2:


Pubmed-CCND2 »
Uniprot-CCND2 »
Biogrid-CCND2 »
ProteomicsDB-CCND2 »

Tumorportal-CCND2 »
COSMIC-CCND2 »
GenomeRNAi-CCND2 »
Genecards-CCND2


Protein-protein Interactions for CCND2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCND2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CCND2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cyclin_A/B/D/E/F IPR014400 0.09
Category members Cyclin_C-dom IPR004367 0
Category members Cyclin_N IPR006671 0
Category members Cyclin-like IPR013763 0


Protein complexes (CORUM database) featuring CCND2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3085 CCND2-CDK4 complex Database 0.11
Category members Corum 5107 p34(SEI-1)-CDK4-CyclinD2 complex Database 0.11
Category members Corum 1642 p16-cyclin D2-CDK4 complex Database 0
Category members Corum 3088 CCND2-CDK6 complex Database 0


Categories featuring CCND2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members GO Category GO:0051301 cell division Database 1.15
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members Pathway Pathway_447 KEGG_JAK_STAT_SIGNALING_PATHWAY 0 0.13
Category members GO Category GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity Database 0.13
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Disease phenotype Megalencephaly_-_polymicrogyria_-_post-axial_polydactyly_-_hydrocephalus Megalencephaly - polymicrogyria - post-axial polydactyly - hydrocephalus Database 0.04
Category members GO Category GO:0045737 positive regulation of cyclin-dependent protein kinase activity Database 0.03
Category members Pathway Pathway_791 REACTOME_G1_PHASE 0 0.02
Category members Disease phenotype MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS_SYNDROME; MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME; Database 0.01
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members Pathway Pathway_567 PID_IL2_STAT5_PATHWAY 0 0
Category members Pathway Pathway_970 BIOCARTA_CELLCYCLE_PATHWAY 0 0
Category members GO Category GO:0000307 cyclin-dependent protein kinase holoenzyme complex Database 0


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