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Query: PPM1D

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PPM1D 0 -1.630 -0.190 -0.110

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PPM1D Phosphorylation S85 -1.520 _DPLPDAGAS(ph)PAPSR_

Background Information for PPM1D:


Pubmed-PPM1D »
Uniprot-PPM1D »
Biogrid-PPM1D »
ProteomicsDB-PPM1D »

Tumorportal-PPM1D »
COSMIC-PPM1D »
GenomeRNAi-PPM1D »
Genecards-PPM1D


Protein-protein Interactions for PPM1D
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in PPM1D
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PP2C-like_dom IPR001932 0.04


Protein complexes (CORUM database) featuring PPM1D
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1183 CDC5L complex Database 2.07


Categories featuring PPM1D
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members GO Category GO:0004722 protein serine/threonine phosphatase activity Database 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0009314 response to radiation Database 0.07
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0009617 response to bacterium Database 0
Category members GO Category GO:0035970 peptidyl-threonine dephosphorylation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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