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Query: RRM2B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RRM2B 1 1.685 -0.160 -0.120

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RRM2B Ubiquitylation K424 2.394 -0.588 _TNFFEK(gl)R_

Background Information for RRM2B:


Pubmed-RRM2B »
Uniprot-RRM2B »
Biogrid-RRM2B »
ProteomicsDB-RRM2B »

Tumorportal-RRM2B »
COSMIC-RRM2B »
GenomeRNAi-RRM2B »
Genecards-RRM2B


Protein-protein Interactions for RRM2B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FZR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRM2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMOD2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RRM2B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RNR_small IPR000358 0
Category members Ferritin-like_SF IPR009078 0


Protein complexes (CORUM database) featuring RRM2B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring RRM2B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0003014 renal system process Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members Disease phenotype Mitochondrial_neurogastrointestinal_encephalomyopathy Mitochondrial neurogastrointestinal encephalomyopathy Database 0.07
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members Pathway Pathway_27 KEGG_GLUTATHIONE_METABOLISM 0 0
Category members Pathway Pathway_274 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES 0 0
Category members Disease phenotype Autosomal_dominant_progressive_external_ophthalmoplegia Autosomal dominant progressive external ophthalmoplegia Database 0
Category members Disease phenotype PROGRESSIVE_EXTERNAL_OPHTHALMOPLEGIA_WITH_MITOCHONDRIAL_DNA_DELETIONS PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS Database 0
Category members GO Category GO:0001822 kidney development Database 0
Category members GO Category GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Database 0
Category members GO Category GO:0006264 mitochondrial DNA replication Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0009186 deoxyribonucleoside diphosphate metabolic process Database 0
Category members GO Category GO:0009263 deoxyribonucleotide biosynthetic process Database 0
Category members GO Category GO:0015949 nucleobase-containing small molecule interconversion Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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