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Query: POLR2A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
POLR2A 3 7.011 -0.397 0.863 1.593 -2.121 0.465

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
POLR2A Ubiquitylation K767 1.702 _SLSEYNNFK(gl)SMVVSGAK_
POLR2A Ubiquitylation K758 -0.129 1.511 _DKTGSSAQK(gl)SLSEYNNFK_
POLR2A Ubiquitylation K751 -0.268 1.477 _DK(gl)TGSSAQK(gl)SLSEYNNFK_
POLR2A Ubiquitylation K127 1.428 _IK(gl)DILAK_
POLR2A Ubiquitylation K710 1.362 1.417 _AK(gl)QDVIEVIEK_
POLR2A Ubiquitylation K707 1.333 _TYQDIQNTIK(gl)K_
POLR2A Ubiquitylation K226 1.254 _VHEIFK(gl)R_
POLR2A Ubiquitylation K775 1.252 _SMVVSGAK(gl)GSK_
POLR2A Ubiquitylation K285 1.235 _LADIVK(gl)INNQLR_
POLR2A Ubiquitylation K1125 4.356 1.173 _LK(gl)ELINISK_
POLR2A Ubiquitylation K149 1.053 _LTHVYDLCK(gl)GK_
POLR2A Ubiquitylation K32 1.006 _VQFGVLSPDELK(gl)R_
POLR2A Ubiquitylation K1350 5.000 0.930 _VLSEK(gl)DVDPVR_
POLR2A Ubiquitylation K279 0.885 _NQDDLTHK(gl)LADIVK_
POLR2A Ubiquitylation K1014 0.766 _VVEGVK(gl)ELSK_
POLR2A Ubiquitylation K417 0.662 _GNSQYPGAK(gl)YIIR_
POLR2A Ubiquitylation K1155 3.909 0.506 _AK(gl)DILCR_
POLR2A Ubiquitylation K132 0.487 _IKDILAK(gl)SK_
POLR2A Ubiquitylation K976 0.145 0.332 _VIFPTGDSK(gl)VVLPCNLLR_
POLR2A Phosphorylation S1882 -0.491 0.086 _YSPTS(ph)PTYS(ph)PTTPK_
POLR2A Phosphorylation T1885 -0.372 -0.103 _YSPTS(ph)PTYSPTT(ph)PK_
POLR2A Ubiquitylation K812 -0.169 _TLPHFIK(gl)DDYGPESR_
POLR2A Phosphorylation S1878 -1.417 -0.623 _YSPTS(ph)PTYSPTT(ph)PK_
POLR2A Phosphorylation S1850 -1.360 -0.983 _YTPTSPSYSPSS(ph)PEYTPTS(ph)PK_
POLR2A Phosphorylation S1899 -0.903 -1.110 _YSPTSPTYSPTS(ph)PVYT(ph)PTSPK_
POLR2A Phosphorylation S1896 -1.174 _YSPTSPTYS(ph)PTSPVYTPT(ph)SPK_
POLR2A Phosphorylation S1920 -1.088 -1.414 _YSPTS(ph)PTYSPTS(ph)PK_
POLR2A Phosphorylation S1843 -1.841 -1.437 _YTPTS(ph)PSYSPSSPEYTPTSPK_
POLR2A Phosphorylation S1910 -1.108 -1.445 _YS(ph)PTSPTYS(ph)PTSPK_
POLR2A Phosphorylation T1919 -2.218 -1.471 _YSPTS(ph)PTYSPT(ph)SPK_
POLR2A Phosphorylation S1889 -1.476 _YS(ph)PTSPTYSPTS(ph)PVYTPTSPK_
POLR2A Phosphorylation S1913 -2.778 -1.508 _YSPTS(ph)PTYSPTS(ph)PK_
POLR2A Phosphorylation T1898 -1.558 _YSPTS(ph)PTYSPT(ph)SPVYTPTSPK_
POLR2A Phosphorylation T1912 -1.639 _YSPT(ph)SPTYS(ph)PTSPK_
POLR2A Phosphorylation S1847 -1.016 -1.726 _Y(ph)TPTSPSYS(ph)PSSPEYTPT(ph)SPK_
POLR2A Phosphorylation T1903 -0.180 -1.726 _YSPTSPTYSPTS(ph)PVYT(ph)PTSPK_
POLR2A Phosphorylation T1856 -1.740 _YTPTSPSYS(ph)PSSPEYTPT(ph)SPK_
POLR2A Phosphorylation Y1846 -1.758 _YTPTSPSY(ph)SPSSPEYTPTS(ph)PK_
POLR2A Phosphorylation S1917 -2.286 -1.773 _YSPTS(ph)PTYS(ph)PTSPK_
POLR2A Phosphorylation T1905 -1.328 -1.788 _YSPTSPTYSPTS(ph)PVYTPT(ph)SPK_
POLR2A Phosphorylation T1840 -1.940 _YT(ph)PTSPSYSPSSPEYTPTSPK_
POLR2A Phosphorylation S1892 -2.675 -2.044 _YSPTS(ph)PTYSPTSPVYTPTSPK_
POLR2A Phosphorylation T1891 -3.041 -2.243 _YSPT(ph)SPTYSPTSPVYTPTSPK_
POLR2A Phosphorylation S1906 -2.720 -2.245 _YSPTS(ph)PTYSPTSPVYTPTS(ph)PK_
POLR2A Phosphorylation S1857 -2.153 -2.282 _YTPTSPSYSPSSPEYTPTS(ph)PK_
POLR2A Phosphorylation S1849 -2.693 _YTPTSPSY(ph)SPS(ph)SPEYTPTSPK_
POLR2A Phosphorylation T1842 -2.070 _YTPT(ph)SPSYS(ph)PSSPEYTPTSPK_
POLR2A Phosphorylation Y1853 -1.665 _YTPTSPSYSPSSPEY(ph)TPT(ph)SPK_
POLR2A Phosphorylation T1877 -0.410 _YSPT(ph)SPTYS(ph)PTTPK_
POLR2A Phosphorylation T1915 -2.612 _YSPTSPT(ph)YSPTSPK_

Background Information for POLR2A:


Pubmed-POLR2A »
Uniprot-POLR2A »
Biogrid-POLR2A »
ProteomicsDB-POLR2A »

Tumorportal-POLR2A »
COSMIC-POLR2A »
GenomeRNAi-POLR2A »
Genecards-POLR2A


Protein-protein Interactions for POLR2A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CTR9 Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait GTF2B Cat. description Hein, Mann, Cell 2015
Category members IP bait MED22 Cat. description Hein, Mann, Cell 2015
Category members IP bait NABP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCIF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PFDN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR2F Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR2G Cat. description Hein, Mann, Cell 2015
Category members IP bait RPRD1B Cat. description Hein, Mann, Cell 2015
Category members IP bait RUVBL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RUVBL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SUPT5H Cat. description Hein, Mann, Cell 2015
Category members IP bait VWA9 Cat. description Hein, Mann, Cell 2015
Category members IP bait WHSC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ASB6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C7orf60 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COLQ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPNE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR156 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GRINL1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LMO2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NFKBIA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIH1D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR2E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR2G Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPRD1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYDE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UXT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WWP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in POLR2A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RNA_pol_asu IPR000722 0.68
Category members RNA_pol_N IPR006592 0.68
Category members RNA_pol_Rpb1_3 IPR007066 0.68
Category members RNA_pol_Rpb1_1 IPR007080 0.68
Category members RNA_pol_Rpb1_5 IPR007081 0.68
Category members RNA_pol_Rpb1_4 IPR007083 0.68
Category members RNA_pol_II_repeat_euk IPR000684 0.34


Protein complexes (CORUM database) featuring POLR2A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1155 Integrator-RNAPII complex Database 5.97
Category members Corum 3137 MASH1 promoter-coactivator complex Database 5.32
Category members Corum 1191 RNA pol II containing coactivator complex Tat-SF Database 2.13
Category members Corum 728 CSA-POLIIa complex Database 1.74
Category members Corum 2825 BRCA1-RNA polymerase II complex Database 1.38
Category members Corum 103 RNA polymerase II holoenzyme complex Database 1.07
Category members Corum 3066 RNA polymerase II complex, chromatin structure modifying Database 0.92
Category members Corum 1769 CPSF6-ITCH-NUDT21-POLR2A complex Database 0.85
Category members Corum 2599 POLR2A-CCNT1-CDK9-NCL-LEM6-CPSF2 complex Database 0.75
Category members Corum 2213 BRCA1-BARD1-POLR2A complex Database 0.66
Category members Corum 3064 RNA polymerase II complex, chromatin structure modifying Database 0.64
Category members Corum 2686 BRCA1-core RNA polymerase II complex Database 0.51
Category members Corum 2639 HES1 promoter-Notch enhancer complex Database 0.45
Category members Corum 1767 CPSF6-ITCH-NUDT21-POLR2A-UBAP2L complex Database 0.43
Category members Corum 3060 RNA polymerase II complex (RPB1, RAP74, CDK8, CYCC, SRB7, BAF190, BAF47), chromatin structure modifying Database 0.35
Category members Corum 3062 RNA polymerase II complex, incomplete (CBP, RPBI, PCAF, BAF47), chromatin structure modifying Database 0.33
Category members Corum 104 RNA polymerase II core complex Database 0.29
Category members Corum 1768 CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex Database 0.23
Category members Corum 3061 RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying Database 0.18
Category members Corum 2685 RNA polymerase II (RNAPII) Database 0.12
Category members Corum 3142 CAMK2-delta-MASH1 promoter-coactivator complex Database 0.07
Category members Corum 5363 Actin-ribonucleoprotein complex (POLR2A, GTF2F1, HNRNPU) Database 0.06
Category members Corum 1749 SMN-PolII-RHA complex Database 0
Category members Corum 2638 HES1 promoter corepressor complex Database 0
Category members Corum 5736 Pre-initiation complex (PIC) Database 0


Categories featuring POLR2A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_369 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION 0 INF
Category members Pathway Pathway_371 REACTOME_INFLUENZA_LIFE_CYCLE 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_374 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 0 7.57
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006283 transcription-coupled nucleotide-excision repair Database 6.58
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members GO Category GO:0050434 positive regulation of viral transcription Database 4.8
Category members Pathway Pathway_336 REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 0 4.6
Category members Pathway Pathway_378 REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX 0 3.95
Category members Pathway Pathway_360 REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ 0 3.35
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members GO Category GO:0006368 transcription elongation from RNA polymerase II promoter Database 2.03
Category members Pathway Pathway_363 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS 0 1.84
Category members Pathway Pathway_367 REACTOME_ELONGATION_ARREST_AND_RECOVERY 0 1.67
Category members Pathway Pathway_361 REACTOME_FORMATION_OF_THE_HIV1_EARLY_ELONGATION_COMPLEX 0 1.57
Category members Pathway Pathway_362 REACTOME_MRNA_CAPPING 0 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_372 REACTOME_MRNA_SPLICING_MINOR_PATHWAY 0 1.52
Category members Pathway Pathway_366 BIOCARTA_TEL_PATHWAY 0 1.44
Category members GO Category GO:0006370 7-methylguanosine mRNA capping Database 1.26
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_349 KEGG_RNA_POLYMERASE 0 0.91
Category members GO Category GO:0001055 RNA polymerase II activity Database 0.54
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members GO Category GO:0003899 DNA-directed RNA polymerase activity Database 0.46
Category members GO Category GO:0005665 DNA-directed RNA polymerase II, core complex Database 0.38
Category members Pathway Pathway_364 REACTOME_ABORTIVE_ELONGATION_OF_HIV1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT 0 0.35
Category members Pathway Pathway_370 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING 0 0.34
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members Pathway Pathway_368 REACTOME_MICRORNA_MIRNA_BIOGENESIS 0 0.18
Category members Pathway Pathway_358 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS 0 0.14
Category members Pathway Pathway_379 REACTOME_REGULATORY_RNA_PATHWAYS 0 0.12
Category members Pathway Pathway_381 BIOCARTA_RARRXR_PATHWAY 0 0.08
Category members Pathway Pathway_359 BIOCARTA_DREAM_PATHWAY 0 0
Category members Pathway Pathway_365 BIOCARTA_CARM_ER_PATHWAY 0 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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