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Query: ERCC3

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ERCC3 2 7.026 -1.110 1.490 2.619 2.418 0.499

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for ERCC3:


Pubmed-ERCC3 »
Uniprot-ERCC3 »
Biogrid-ERCC3 »
ProteomicsDB-ERCC3 »

Tumorportal-ERCC3 »
COSMIC-ERCC3 »
GenomeRNAi-ERCC3 »
Genecards-ERCC3


Protein-protein Interactions for ERCC3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GSPT1;GSPT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GTF2H5 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait ERCC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTF2H2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LZTS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NSUN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ERCC3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members Helicase/UvrB_dom IPR006935 0.78


Protein complexes (CORUM database) featuring ERCC3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1141 CF IIAm complex (Cleavage factor IIAm complex) Database 2.57
Category members Corum 1037 TFIIH transcription factor core complex Database 1.41
Category members Corum 2825 BRCA1-RNA polymerase II complex Database 1.38
Category members Corum 103 RNA polymerase II holoenzyme complex Database 1.07
Category members Corum 3066 RNA polymerase II complex, chromatin structure modifying Database 0.92
Category members Corum 1009 TFIIH transcription factor complex Database 0.82
Category members Corum 1029 TFIIH transcription factor complex Database 0.82
Category members Corum 1036 TFIIH transcription factor complex Database 0.82
Category members Corum 107 TFIIH transcription factor complex Database 0.82
Category members Corum 5495 TFIIH transcription factor complex (ERCC2, ERCC3, GTF2H1, CDK7, CCNH, GTF2H2) Database 0.67
Category members Corum 443 BP-SMAD complex Database 0


Categories featuring ERCC3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_351 REACTOME_RNA_POL_I_TRANSCRIPTION 0 8.31
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_350 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION 0 7.97
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_374 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 0 7.57
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006283 transcription-coupled nucleotide-excision repair Database 6.58
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0050434 positive regulation of viral transcription Database 4.8
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members Pathway Pathway_336 REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 0 4.6
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Pathway Pathway_857 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER 0 4.24
Category members Pathway Pathway_378 REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX 0 3.95
Category members GO Category GO:0000718 nucleotide-excision repair, DNA damage removal Database 3.83
Category members Pathway Pathway_346 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION 0 3.42
Category members Pathway Pathway_360 REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ 0 3.35
Category members Pathway Pathway_344 REACTOME_GLOBAL_GENOMIC_NER_GG_NER 0 3.29
Category members GO Category GO:0006360 transcription from RNA polymerase I promoter Database 2.66
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members GO Category GO:0006361 transcription initiation from RNA polymerase I promoter Database 2.41
Category members GO Category GO:0008094 DNA-dependent ATPase activity Database 2.31
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0006368 transcription elongation from RNA polymerase II promoter Database 2.03
Category members GO Category GO:0006265 DNA topological change Database 1.92
Category members Pathway Pathway_345 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION 0 1.9
Category members Pathway Pathway_363 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS 0 1.84
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0006363 termination of RNA polymerase I transcription Database 1.71
Category members Pathway Pathway_361 REACTOME_FORMATION_OF_THE_HIV1_EARLY_ELONGATION_COMPLEX 0 1.57
Category members Pathway Pathway_362 REACTOME_MRNA_CAPPING 0 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006362 transcription elongation from RNA polymerase I promoter Database 1.47
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0032564 dATP binding Database 1.31
Category members GO Category GO:0006370 7-methylguanosine mRNA capping Database 1.26
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members GO Category GO:0005675 holo TFIIH complex Database 0.83
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0009411 response to UV Database 0.79
Category members GO Category GO:0009650 UV protection Database 0.68
Category members GO Category GO:0008104 protein localization Database 0.5
Category members GO Category GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity Database 0.42
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Disease phenotype TRICHOTHIODYSTROPHY_PHOTOSENSITIVE TRICHOTHIODYSTROPHY PHOTOSENSITIVE Database 0.35
Category members GO Category GO:0000441 SSL2-core TFIIH complex Database 0.35
Category members Pathway Pathway_370 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING 0 0.34
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Disease phenotype TRICHOTHIODYSTROPHY_NONPHOTOSENSITIVE_1 TRICHOTHIODYSTROPHY NONPHOTOSENSITIVE 1 Database 0.25
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0035315 hair cell differentiation Database 0.17
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_381 BIOCARTA_RARRXR_PATHWAY 0 0.08
Category members GO Category GO:0033683 nucleotide-excision repair, DNA incision Database 0.06
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_365 BIOCARTA_CARM_ER_PATHWAY 0 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0042277 peptide binding Database 0
Category members GO Category GO:0043138 3'-5' DNA helicase activity Database 0


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