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Query: GATA4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GATA4 0 0.289 -0.670 0.350

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GATA4 Phosphorylation S407 -0.185 0.124 _LS(ph)PQGYASPVSQSPQTSSK_
GATA4 Phosphorylation S109 -0.520 -0.425 _FS(ph)FPGTTGSLAAAAAAAAAR_

Background Information for GATA4:


Pubmed-GATA4 »
Uniprot-GATA4 »
Biogrid-GATA4 »
ProteomicsDB-GATA4 »

Tumorportal-GATA4 »
COSMIC-GATA4 »
GenomeRNAi-GATA4 »
Genecards-GATA4


Protein-protein Interactions for GATA4
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in GATA4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_GATA IPR000679 0.29
Category members GATA_N IPR008013 0.04
Category members TF_GATA_4/5/6 IPR016375 0


Protein complexes (CORUM database) featuring GATA4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3917 Ternary complex (GATA4, SRF, MYOCD) Database 0


Categories featuring GATA4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0007267 cell-cell signaling Database 0.94
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0043627 response to estrogen Database 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0003197 endocardial cushion development Database 0.31
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0009612 response to mechanical stimulus Database 0.23
Category members GO Category GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding Database 0.21
Category members GO Category GO:0030509 BMP signaling pathway Database 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0045766 positive regulation of angiogenesis Database 0.19
Category members GO Category GO:0003181 atrioventricular valve morphogenesis Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Disease phenotype TETRALOGY_OF_FALLOT TETRALOGY OF FALLOT Database 0.11
Category members GO Category GO:0051891 positive regulation of cardioblast differentiation Database 0.1
Category members Pathway Pathway_270 REACTOME_REGULATION_OF_INSULIN_SECRETION 0 0.09
Category members GO Category GO:0060045 positive regulation of cardiac muscle cell proliferation Database 0.09
Category members GO Category GO:0001706 endoderm formation Database 0.08
Category members GO Category GO:0001947 heart looping Database 0.08
Category members GO Category GO:0023019 signal transduction involved in regulation of gene expression Database 0.08
Category members GO Category GO:0003208 cardiac ventricle morphogenesis Database 0.08
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members GO Category GO:0007492 endoderm development Database 0.06
Category members GO Category GO:0030513 positive regulation of BMP signaling pathway Database 0.05
Category members GO Category GO:0048557 embryonic digestive tract morphogenesis Database 0.04
Category members GO Category GO:0070410 co-SMAD binding Database 0.03
Category members GO Category GO:0060413 atrial septum morphogenesis Database 0.02
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_119 PID_HES_HEY_PATHWAY 0 0
Category members Pathway Pathway_641 BIOCARTA_NFAT_PATHWAY 0 0
Category members Pathway Pathway_872 BIOCARTA_ALK_PATHWAY 0 0
Category members Pathway Pathway_917 REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION 0 0
Category members Pathway Pathway_919 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP 0 0
Category members Disease phenotype 46XY_partial_gonadal_dysgenesis 46XY partial gonadal dysgenesis Database 0
Category members Disease phenotype Atrial_septal_defect_ostium_secundum_type Atrial septal defect ostium secundum type Database 0
Category members Disease phenotype Complete_atrioventricular_canal_-_Fallot_tetralogy Complete atrioventricular canal - Fallot tetralogy Database 0
Category members Disease phenotype Complete_atrioventricular_canal_-_left_heart_obstruction Complete atrioventricular canal - left heart obstruction Database 0
Category members Disease phenotype Complete_atrioventricular_canal_-_ventricle_hypoplasia Complete atrioventricular canal - ventricle hypoplasia Database 0
Category members Disease phenotype Familial_atrial_fibrillation Familial atrial fibrillation Database 0
Category members Disease phenotype Partial_atrioventricular_canal Partial atrioventricular canal Database 0
Category members Disease phenotype Single_ventricular_septal_defect Single ventricular septal defect Database 0
Category members GO Category GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity Database 0
Category members GO Category GO:0001076 RNA polymerase II transcription factor binding transcription factor activity Database 0
Category members GO Category GO:0001158 enhancer sequence-specific DNA binding Database 0
Category members GO Category GO:0001702 gastrulation with mouth forming second Database 0
Category members GO Category GO:0003215 cardiac right ventricle morphogenesis Database 0
Category members GO Category GO:0003229 ventricular cardiac muscle tissue development Database 0
Category members GO Category GO:0003281 ventricular septum development Database 0
Category members GO Category GO:0003289 atrial septum primum morphogenesis Database 0
Category members GO Category GO:0003290 atrial septum secundum morphogenesis Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0008584 male gonad development Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0010507 negative regulation of autophagy Database 0
Category members GO Category GO:0010575 positive regulation vascular endothelial growth factor production Database 0
Category members GO Category GO:0014898 cardiac muscle hypertrophy in response to stress Database 0
Category members GO Category GO:0033613 activating transcription factor binding Database 0
Category members GO Category GO:0035050 embryonic heart tube development Database 0
Category members GO Category GO:0035054 embryonic heart tube anterior/posterior pattern specification Database 0
Category members GO Category GO:0035239 tube morphogenesis Database 0
Category members GO Category GO:0048598 embryonic morphogenesis Database 0
Category members GO Category GO:0048617 embryonic foregut morphogenesis Database 0
Category members GO Category GO:0048738 cardiac muscle tissue development Database 0
Category members GO Category GO:0051525 NFAT protein binding Database 0
Category members GO Category GO:0055007 cardiac muscle cell differentiation Database 0
Category members GO Category GO:0060008 Sertoli cell differentiation Database 0
Category members GO Category GO:0060043 regulation of cardiac muscle cell proliferation Database 0
Category members GO Category GO:0060070 canonical Wnt signaling pathway Database 0
Category members GO Category GO:0060395 SMAD protein signal transduction Database 0
Category members GO Category GO:0060575 intestinal epithelial cell differentiation Database 0
Category members GO Category GO:0061049 cell growth involved in cardiac muscle cell development Database 0
Category members GO Category GO:0071333 cellular response to glucose stimulus Database 0
Category members GO Category GO:0071371 cellular response to gonadotropin stimulus Database 0
Category members GO Category GO:0071372 cellular response to follicle-stimulating hormone stimulus Database 0


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