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Query: CTBP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CTBP1 0 1.741 -0.410 0.390
CTBP1 0 1.741 -0.410 0.390 -0.293 -0.875 0.361 0.407 -0.049
CTBP1 0 1.741 -0.410 0.390 1.494 -0.398 0.504 0.897 -0.123

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CTBP1 Ubiquitylation K286 0.130 0.008 _ALAQALK(gl)EGR_
CTBP1 Phosphorylation S492 -1.548 _YPPGIVGVAPGGLPAAM(ox)EGIIPGGIPVTHNLPTVAHPS(ph)QAPSPNQPTK_
CTBP1 Ubiquitylation K279 0.443 _GGLVDEK(gl)ALAQALK_

Background Information for CTBP1:


Pubmed-CTBP1 »
Uniprot-CTBP1 »
Biogrid-CTBP1 »
ProteomicsDB-CTBP1 »

Tumorportal-CTBP1 »
COSMIC-CTBP1 »
GenomeRNAi-CTBP1 »
Genecards-CTBP1


Protein-protein Interactions for CTBP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APC Cat. description Hein, Mann, Cell 2015
Category members IP bait CTBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CTBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IGFBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CTBP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members 6PGDH_NADP-bd IPR006115 0.04
Category members D-isomer_DH_NAD-bd IPR006140 0.03
Category members D-isomer_2_OHA_DH_cat_dom IPR006139 0


Protein complexes (CORUM database) featuring CTBP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 642 CtBP complex Database 3.6
Category members Corum 643 CtBP core complex Database 1.41
Category members Corum 626 LSD1 complex Database 0.17
Category members Corum 2921 SHARP-CtBP complex Database 0.08
Category members Corum 2931 SHARP-CtBP1-CtIP-RBP-Jkappa corepressor complex Database 0.04
Category members Corum 2819 BRCA1-CtIP-CtBP complex Database 0
Category members Corum 2923 SHARP-CtBP1-CtIP complex Database 0


Categories featuring CTBP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0051287 NAD binding Database 1.6
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Database 0.29
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members GO Category GO:0019079 viral genome replication Database 0.22
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members GO Category GO:0031065 positive regulation of histone deacetylation Database 0.21
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0007030 Golgi organization Database 0.13
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Pathway Pathway_941 BIOCARTA_WNT_PATHWAY 0 0.08
Category members GO Category GO:0035067 negative regulation of histone acetylation Database 0.08
Category members GO Category GO:0048037 cofactor binding Database 0.08
Category members GO Category GO:0006098 pentose-phosphate shunt Database 0.07
Category members GO Category GO:0001106 RNA polymerase II transcription corepressor activity Database 0.06
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity Database 0.04
Category members Pathway Pathway_942 PID_PS1_PATHWAY 0 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_119 PID_HES_HEY_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members Pathway Pathway_892 KEGG_NOTCH_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0050872 white fat cell differentiation Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0
Category members GO Category GO:0070491 repressing transcription factor binding Database 0


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