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Query: KDM1A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
KDM1A 1 4.679 -1.020 1.190 1.814 0.225
KDM1A 1 4.679 -1.020 1.190 0.355 0.031 0.593

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
KDM1A Phosphorylation S137 0.122 0.511 _EM(ox)DESLANLS(ph)EDEYYS(ph)EEER_
KDM1A Phosphorylation S126 0.780 0.501 _EMDES(ph)LANLSEDEYYS(ph)EEER_
KDM1A Phosphorylation S131 0.204 0.473 _EM(ox)DESLANLS(ph)EDEYYS(ph)EEER_
KDM1A Phosphorylation S166 -2.328 -2.624 _KLPPPPPQAPPEEENES(ph)EPEEPSGVEGAAFQSR_
KDM1A Phosphorylation S69 -2.048 -2.645 _KEPPRAS(ph)PPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGR_
KDM1A Ubiquitylation K296 -0.820 _IKPLPTK(gl)K_
KDM1A Ubiquitylation K297 -0.820 _IKPLPTK(gl)K_
KDM1A Ubiquitylation K507 -1.073 _DITAEFLVKSK(gl)_
KDM1A Phosphorylation T88 -1.832 _KEPPRASPPGGLAEPPGSAGPQAGPT(ph)VVPGSATPM(ox)ETGIAETPEGR_

Background Information for KDM1A:


Pubmed-KDM1A »
Uniprot-KDM1A »
Biogrid-KDM1A »
ProteomicsDB-KDM1A »

Tumorportal-KDM1A »
COSMIC-KDM1A »
GenomeRNAi-KDM1A »
Genecards-KDM1A


Protein-protein Interactions for KDM1A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CTBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HMG20A Cat. description Hein, Mann, Cell 2015
Category members IP bait UFL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARRDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C15orf27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CTBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ECE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HDAC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HMG20A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HMG20B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZSCAN5A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in KDM1A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SWIRM IPR007526 1.31
Category members Pyr_OxRdtase_NAD-bd_dom IPR001327 0.03
Category members Amino_oxidase IPR002937 0
Category members FAD_bind_dom IPR003953 0
Category members FAD-dep_OxRdtase IPR006076 0
Category members Homeodomain-like IPR009057 0


Protein complexes (CORUM database) featuring KDM1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1257 ALL-1 supercomplex Database 4.3
Category members Corum 642 CtBP complex Database 3.6
Category members Corum 646 HDAC1-associated protein complex Database 3.34
Category members Corum 614 NRD complex (Nucleosome remodeling and deacetylation complex) Database 2.26
Category members Corum 632 Anti-HDAC2 complex Database 2.11
Category members Corum 643 CtBP core complex Database 1.41
Category members Corum 634 XFIM complex Database 1.15
Category members Corum 648 HDAC1-associated core complex cI Database 0.75
Category members Corum 633 anti-BHC110 complex Database 0.53
Category members Corum 636 BHC complex Database 0.53
Category members Corum 1492 BHC110 complex Database 0.39
Category members Corum 620 CoREST-HDAC complex Database 0.34
Category members Corum 871 BRAF53-BRCA2 complex Database 0.34
Category members Corum 624 LSD1-CoREST complex Database 0.31
Category members Corum 626 LSD1 complex Database 0.17
Category members Corum 2160 AOF2-AR complex Database 0


Categories featuring KDM1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0051573 negative regulation of histone H3-K9 methylation Database 0.84
Category members GO Category GO:0032452 histone demethylase activity Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0032454 histone demethylase activity (H3-K9 specific) Database 0.29
Category members GO Category GO:0045654 positive regulation of megakaryocyte differentiation Database 0.28
Category members GO Category GO:0045648 positive regulation of erythrocyte differentiation Database 0.23
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity Database 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0050660 flavin adenine dinucleotide binding Database 0.12
Category members GO Category GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity Database 0.12
Category members GO Category GO:0050681 androgen receptor binding Database 0.12
Category members GO Category GO:0051572 negative regulation of histone H3-K4 methylation Database 0.08
Category members GO Category GO:0032091 negative regulation of protein binding Database 0.08
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0033169 histone H3-K9 demethylation Database 0.05
Category members GO Category GO:0006482 protein demethylation Database 0.05
Category members GO Category GO:0034720 histone H3-K4 demethylation Database 0.05
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0043392 negative regulation of DNA binding Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_119 PID_HES_HEY_PATHWAY 0 0
Category members GO Category GO:0001085 RNA polymerase II transcription factor binding Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0021983 pituitary gland development Database 0
Category members GO Category GO:0030851 granulocyte differentiation Database 0
Category members GO Category GO:0032451 demethylase activity Database 0
Category members GO Category GO:0032453 histone demethylase activity (H3-K4 specific) Database 0
Category members GO Category GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific) Database 0
Category members GO Category GO:0043426 MRF binding Database 0
Category members GO Category GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator Database 0
Category members GO Category GO:0046886 positive regulation of hormone biosynthetic process Database 0
Category members GO Category GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0055001 muscle cell development Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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