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Query: TCF3

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TCF3 0 1.621 0.270 -0.020

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TCF3 Phosphorylation S328 0.865 0.756 _AGAPGALS(ph)PSYDGGLHGLQSK_

Background Information for TCF3:


Pubmed-TCF3 »
Uniprot-TCF3 »
Biogrid-TCF3 »
ProteomicsDB-TCF3 »

Tumorportal-TCF3 »
COSMIC-TCF3 »
GenomeRNAi-TCF3 »
Genecards-TCF3


Protein-protein Interactions for TCF3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCOR Cat. description Hein, Mann, Cell 2015
Category members IP bait DCTN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ID1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ID2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF13B Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF18A Cat. description Hein, Mann, Cell 2015
Category members IP bait FERD3L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FKBP9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLT25D2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ID2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MESP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYOG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NEUROD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NEUROG3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TCF3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members bHLH_dom IPR011598 0.32


Protein complexes (CORUM database) featuring TCF3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 302 INO80 chromatin remodeling complex Database 0.14
Category members Corum 1372 Rb-tal-1-E2A-Lmo2-Ldb1 complex Database 0.05


Categories featuring TCF3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0033152 immunoglobulin V(D)J recombination Database 0.46
Category members Pathway Pathway_444 PID_P38_MK2_PATHWAY 0 0.42
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0032496 response to lipopolysaccharide Database 0.35
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members Disease phenotype Precursor_B-cell_acute_lymphoblastic_leukemia Precursor B-cell acute lymphoblastic leukemia Database 0.25
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0042692 muscle cell differentiation Database 0.1
Category members GO Category GO:0050821 protein stabilization Database 0.04
Category members GO Category GO:0045787 positive regulation of cell cycle Database 0.04
Category members GO Category GO:0051149 positive regulation of muscle cell differentiation Database 0.04
Category members GO Category GO:0002326 B cell lineage commitment Database 0.04
Category members GO Category GO:0033077 T cell differentiation in thymus Database 0.03
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_1038 REACTOME_MYOGENESIS 0 0
Category members Pathway Pathway_119 PID_HES_HEY_PATHWAY 0 0
Category members Disease phenotype Autosomal_agammaglobulinemia Autosomal agammaglobulinemia Database 0
Category members GO Category GO:0000788 nuclear nucleosome Database 0
Category members GO Category GO:0001779 natural killer cell differentiation Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0030098 lymphocyte differentiation Database 0
Category members GO Category GO:0030183 B cell differentiation Database 0
Category members GO Category GO:0030890 positive regulation of B cell proliferation Database 0
Category members GO Category GO:0031435 mitogen-activated protein kinase kinase kinase binding Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043425 bHLH transcription factor binding Database 0
Category members GO Category GO:0043966 histone H3 acetylation Database 0
Category members GO Category GO:0043967 histone H4 acetylation Database 0
Category members GO Category GO:0045666 positive regulation of neuron differentiation Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0048468 cell development Database 0
Category members GO Category GO:0048541 Peyer's patch development Database 0
Category members GO Category GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0070491 repressing transcription factor binding Database 0
Category members GO Category GO:0070644 vitamin D response element binding Database 0
Category members GO Category GO:0070888 E-box binding Database 0


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