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Query: RBBP8

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RBBP8 0 -0.116 0.120 0.020

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RBBP8 Phosphorylation S327 -0.154 0.038 _VSS(ph)PVFGATSSIK_

Background Information for RBBP8:


Pubmed-RBBP8 »
Uniprot-RBBP8 »
Biogrid-RBBP8 »
ProteomicsDB-RBBP8 »

Tumorportal-RBBP8 »
COSMIC-RBBP8 »
GenomeRNAi-RBBP8 »
Genecards-RBBP8


Protein-protein Interactions for RBBP8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BUB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP135 Cat. description Hein, Mann, Cell 2015
Category members IP bait HOMER1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF7 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait PLK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPX2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ERP44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCOC Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RBBP8
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring RBBP8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2815 BRCA1-BARD1-BACH1-DNA damage complex II Database 1.57
Category members Corum 2787 BRCA1 C complex Database 0.66
Category members Corum 2930 SHARP-CtIP-RBP-Jkappa complex Database 0.24
Category members Corum 2931 SHARP-CtBP1-CtIP-RBP-Jkappa corepressor complex Database 0.04
Category members Corum 2214 LMO4-BRCA1-CTIP-LDB1 complex Database 0
Category members Corum 2215 BRCA1-LMO4-CTIP complex Database 0
Category members Corum 240 BRCA1-CTIP-ZBRK1 repressor complex Database 0
Category members Corum 2819 BRCA1-CtIP-CtBP complex Database 0
Category members Corum 2923 SHARP-CtBP1-CtIP complex Database 0


Categories featuring RBBP8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members Pathway Pathway_874 REACTOME_MEIOTIC_RECOMBINATION 0 3.7
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members GO Category GO:0000724 double-strand break repair via homologous recombination Database 2.41
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members Pathway Pathway_980 BIOCARTA_ATM_PATHWAY 0 0.46
Category members GO Category GO:0001103 RNA polymerase II repressing transcription factor binding Database 0.36
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members Disease phenotype Seckel_syndrome Seckel syndrome Database 0.25
Category members GO Category GO:0000014 single-stranded DNA endodeoxyribonuclease activity Database 0.23
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0001835 blastocyst hatching Database 0.08
Category members GO Category GO:0001106 RNA polymerase II transcription corepressor activity Database 0.06
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0007126 meiosis Database 0.01
Category members Pathway Pathway_119 PID_HES_HEY_PATHWAY 0 0
Category members GO Category GO:0000075 cell cycle checkpoint Database 0
Category members GO Category GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing Database 0
Category members GO Category GO:0031572 G2 DNA damage checkpoint Database 0


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