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Query: PTCH1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PTCH1 0 -0.390 0.630 -0.690

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PTCH1 Ubiquitylation K904 -0.390 _DKPIDISQLTK(gl)QR_

Background Information for PTCH1:


Pubmed-PTCH1 »
Uniprot-PTCH1 »
Biogrid-PTCH1 »
ProteomicsDB-PTCH1 »

Tumorportal-PTCH1 »
COSMIC-PTCH1 »
GenomeRNAi-PTCH1 »
Genecards-PTCH1


Protein-protein Interactions for PTCH1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PTCH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PTCH1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SSD IPR000731 0.17
Category members Patched IPR003392 0.09
Category members TM_rcpt_patched IPR004766 0


Protein complexes (CORUM database) featuring PTCH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5551 CDC2-CCNB1-PTCH1 complex Database 0.44


Categories featuring PTCH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_1105 REACTOME_GPCR_LIGAND_BINDING 0 2.35
Category members GO Category GO:0007224 smoothened signaling pathway Database 2.11
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_1104 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS 0 0.93
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0016485 protein processing Database 0.57
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0045668 negative regulation of osteoblast differentiation Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0008201 heparin binding Database 0.27
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0009612 response to mechanical stimulus Database 0.23
Category members GO Category GO:0050680 negative regulation of epithelial cell proliferation Database 0.19
Category members GO Category GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity Database 0.18
Category members GO Category GO:0007389 pattern specification process Database 0.18
Category members GO Category GO:0021997 neural plate axis specification Database 0.18
Category members GO Category GO:0042593 glucose homeostasis Database 0.18
Category members GO Category GO:0051782 negative regulation of cell division Database 0.17
Category members GO Category GO:0008589 regulation of smoothened signaling pathway Database 0.11
Category members Pathway Pathway_984 PID_HEDGEHOG_GLI_PATHWAY 0 0.1
Category members GO Category GO:0021532 neural tube patterning Database 0.1
Category members GO Category GO:0010157 response to chlorate Database 0.08
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0015485 cholesterol binding Database 0.04
Category members GO Category GO:0008158 hedgehog receptor activity Database 0.04
Category members GO Category GO:0061005 cell differentiation involved in kidney development Database 0.04
Category members Pathway Pathway_1151 KEGG_HEDGEHOG_SIGNALING_PATHWAY 0 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0043616 keratinocyte proliferation Database 0.01
Category members Pathway Pathway_1154 BIOCARTA_SHH_PATHWAY 0 0
Category members Pathway Pathway_1163 KEGG_BASAL_CELL_CARCINOMA 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_594 PID_HEDGEHOG_2PATHWAY 0 0
Category members Pathway Pathway_969 BIOCARTA_PTC1_PATHWAY 0 0
Category members Disease phenotype Alobar_holoprosencephaly Alobar holoprosencephaly Database 0
Category members Disease phenotype BASAL_CELL_CARCINOMA_SUSCEPTIBILITY_TO_1 BASAL CELL CARCINOMA SUSCEPTIBILITY TO 1 Database 0
Category members Disease phenotype Lobar_holoprosencephaly Lobar holoprosencephaly Database 0
Category members Disease phenotype Microform_holoprosencephaly Microform holoprosencephaly Database 0
Category members Disease phenotype Midline_interhemispheric_variant_of_holoprosencephaly Midline interhemispheric variant of holoprosencephaly Database 0
Category members Disease phenotype Semilobar_holoprosencephaly Semilobar holoprosencephaly Database 0
Category members Disease phenotype Septopreoptic_holoprosencephaly Septopreoptic holoprosencephaly Database 0
Category members GO Category GO:0001658 branching involved in ureteric bud morphogenesis Database 0
Category members GO Category GO:0001841 neural tube formation Database 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0003007 heart morphogenesis Database 0
Category members GO Category GO:0005113 patched binding Database 0
Category members GO Category GO:0005119 smoothened binding Database 0
Category members GO Category GO:0005901 caveola Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007346 regulation of mitotic cell cycle Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0008544 epidermis development Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0009953 dorsal/ventral pattern formation Database 0
Category members GO Category GO:0010875 positive regulation of cholesterol efflux Database 0
Category members GO Category GO:0014069 postsynaptic density Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0021522 spinal cord motor neuron differentiation Database 0
Category members GO Category GO:0021904 dorsal/ventral neural tube patterning Database 0
Category members GO Category GO:0030326 embryonic limb morphogenesis Database 0
Category members GO Category GO:0030332 cyclin binding Database 0
Category members GO Category GO:0030879 mammary gland development Database 0
Category members GO Category GO:0032355 response to estradiol Database 0
Category members GO Category GO:0032526 response to retinoic acid Database 0
Category members GO Category GO:0032880 regulation of protein localization Database 0
Category members GO Category GO:0035108 limb morphogenesis Database 0
Category members GO Category GO:0035137 hindlimb morphogenesis Database 0
Category members GO Category GO:0040008 regulation of growth Database 0
Category members GO Category GO:0040015 negative regulation of multicellular organism growth Database 0
Category members GO Category GO:0044294 dendritic growth cone Database 0
Category members GO Category GO:0044295 axonal growth cone Database 0
Category members GO Category GO:0045879 negative regulation of smoothened signaling pathway Database 0
Category members GO Category GO:0060037 pharyngeal system development Database 0
Category members GO Category GO:0060603 mammary gland duct morphogenesis Database 0
Category members GO Category GO:0060644 mammary gland epithelial cell differentiation Database 0
Category members GO Category GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning Database 0
Category members GO Category GO:0061053 somite development Database 0
Category members GO Category GO:0071397 cellular response to cholesterol Database 0


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