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Query: SUFU

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SUFU 0 -0.571 1.190 -0.990

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SUFU Phosphorylation S346 0.344 0.498 _KDS(ph)LESDSSTAIIPHELIR_
SUFU Ubiquitylation K321 -1.917 -1.398 _GLEINSK(gl)PVLPPINPQR_
SUFU Ubiquitylation K303 -0.015 _RLSGK(gl)DTEQIR_

Background Information for SUFU:


Pubmed-SUFU »
Uniprot-SUFU »
Biogrid-SUFU »
ProteomicsDB-SUFU »

Tumorportal-SUFU »
COSMIC-SUFU »
GenomeRNAi-SUFU »
Genecards-SUFU


Protein-protein Interactions for SUFU
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EDEM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ALDH1B1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BFSP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BMP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C18orf1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDC25C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM90A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LIPT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LOXL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC36 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NFATC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NR2E1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NXPH3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OVOL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PEX11A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRPF31 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TTLL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBE2CBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFC3H1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF747 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF764 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF785 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SUFU
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring SUFU
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SUFU
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0045668 negative regulation of osteoblast differentiation Database 0.29
Category members GO Category GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity Database 0.18
Category members GO Category GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification Database 0.18
Category members GO Category GO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Database 0.18
Category members GO Category GO:0042994 cytoplasmic sequestering of transcription factor Database 0.14
Category members Pathway Pathway_984 PID_HEDGEHOG_GLI_PATHWAY 0 0.1
Category members GO Category GO:0001947 heart looping Database 0.08
Category members Disease phenotype Medulloblastoma Medulloblastoma Database 0.08
Category members Pathway Pathway_1151 KEGG_HEDGEHOG_SIGNALING_PATHWAY 0 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_1154 BIOCARTA_SHH_PATHWAY 0 0
Category members Pathway Pathway_1163 KEGG_BASAL_CELL_CARCINOMA 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Disease phenotype Familial_multiple_meningioma Familial multiple meningioma Database 0
Category members GO Category GO:0001501 skeletal system development Database 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005929 cilium Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007368 determination of left/right symmetry Database 0
Category members GO Category GO:0021513 spinal cord dorsal/ventral patterning Database 0
Category members GO Category GO:0042992 negative regulation of transcription factor import into nucleus Database 0
Category members GO Category GO:0043588 skin development Database 0
Category members GO Category GO:0045879 negative regulation of smoothened signaling pathway Database 0


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