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Query: BTRC

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BTRC 0 0.069 -0.780 0.690 0.532 -1.791 0.313

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BTRC Ubiquitylation K466 0.325 _IVSGAYDGKIK(gl)_

Background Information for BTRC:


Pubmed-BTRC »
Uniprot-BTRC »
Biogrid-BTRC »
ProteomicsDB-BTRC »

Tumorportal-BTRC »
COSMIC-BTRC »
GenomeRNAi-BTRC »
Genecards-BTRC


Protein-protein Interactions for BTRC
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APBA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL2L11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BTRC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C9orf25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDC25A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DLD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXW11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR161 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INTU Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KHDRBS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LSP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUAK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUAK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLEKHG5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRICKLE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SH3BP5L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPANXN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPATA20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TACC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TFAP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSC22D4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WWTR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF704 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BTRC
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members G-protein_beta_WD-40_rep IPR020472 0.12
Category members Beta-TrCP_D IPR021977 0.08
Category members F-box_dom IPR001810 0


Protein complexes (CORUM database) featuring BTRC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5196 TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) Database 1.67
Category members Corum 2187 Ubiquitin E3 ligase (NFKBIA, FBXW11, BTRC, CUL1, SKP1A) Database 0.2
Category members Corum 2188 Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1) Database 0.04
Category members Corum 2189 Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1) Database 0.04
Category members Corum 2724 Ubiquitin E3 ligase (NFKBIA, BTRC, CUL1, SKP1A) Database 0.04
Category members Corum 227 Ubiquitin E3 ligase (SKP1A, BTRC, CUL1) Database 0


Categories featuring BTRC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.38
Category members GO Category GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.26
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_807 REACTOME_SIGNALING_BY_WNT 0 2.74
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members GO Category GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Database 2.59
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members Pathway Pathway_706 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 0 1.96
Category members Pathway Pathway_788 REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 0 1.91
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_811 REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 0 1.14
Category members Pathway Pathway_157 REACTOME_CIRCADIAN_CLOCK 0 0.92
Category members Pathway Pathway_804 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 0 0.86
Category members Pathway Pathway_975 REACTOME_IL1_SIGNALING 0 0.42
Category members GO Category GO:0030163 protein catabolic process Database 0.38
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members Pathway Pathway_1173 BIOCARTA_PS1_PATHWAY 0 0.28
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity Database 0.18
Category members GO Category GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling Database 0.17
Category members Pathway Pathway_974 REACTOME_PROLACTIN_RECEPTOR_SIGNALING 0 0.13
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members GO Category GO:0019005 SCF ubiquitin ligase complex Database 0.09
Category members GO Category GO:0033598 mammary gland epithelial cell proliferation Database 0.09
Category members Pathway Pathway_941 BIOCARTA_WNT_PATHWAY 0 0.08
Category members GO Category GO:0042753 positive regulation of circadian rhythm Database 0.08
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members Pathway Pathway_1151 KEGG_HEDGEHOG_SIGNALING_PATHWAY 0 0.04
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_977 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 0 0
Category members Disease phenotype Split_hand-split_foot_malformation Split hand-split foot malformation Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0031648 protein destabilization Database 0
Category members GO Category GO:0045309 protein phosphorylated amino acid binding Database 0
Category members GO Category GO:0045862 positive regulation of proteolysis Database 0
Category members GO Category GO:0045879 negative regulation of smoothened signaling pathway Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0060444 branching involved in mammary gland duct morphogenesis Database 0
Category members GO Category GO:0061136 regulation of proteasomal protein catabolic process Database 0
Category members GO Category GO:0071407 cellular response to organic cyclic compound Database 0


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