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Query: FGFR1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FGFR1 0 0.826 0.210 0.150

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FGFR1 Ubiquitylation K510 1.047 -0.221 _VTK(gl)VAVK_

Background Information for FGFR1:


Pubmed-FGFR1 »
Uniprot-FGFR1 »
Biogrid-FGFR1 »
ProteomicsDB-FGFR1 »

Tumorportal-FGFR1 »
COSMIC-FGFR1 »
GenomeRNAi-FGFR1 »
Genecards-FGFR1


Protein-protein Interactions for FGFR1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FGFR1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C14orf37 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C16orf58 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C19orf45 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C6orf72 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD79B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EVI2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM8A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FCGRT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGFR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GAD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GOLGA7B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HEPACAM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IFNGR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL27RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LITAF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MANSC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MREG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAET1E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCN3B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TGFBR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM30B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF10B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPCN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSPAN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZDHHC11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FGFR1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ig-like_dom IPR007110 0.6
Category members Ig_sub IPR003599 0.43
Category members Immunoglobulin IPR013151 0.23
Category members Ig_sub2 IPR003598 0.21
Category members Ig_I-set IPR013098 0.13
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members FGF_rcpt_fam IPR016248 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring FGFR1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring FGFR1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_1076 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 0 0.44
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members Pathway Pathway_592 REACTOME_SIGNALING_BY_FGFR1_MUTANTS 0 0.4
Category members GO Category GO:0030324 lung development Database 0.39
Category members Pathway Pathway_590 REACTOME_PI_3K_CASCADE 0 0.37
Category members Pathway Pathway_528 REACTOME_SIGNALING_BY_FGFR_MUTANTS 0 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_214 REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 0 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_562 PID_NCADHERIN_PATHWAY 0 0.29
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members Pathway Pathway_1093 PID_SYNDECAN_4_PATHWAY 0 0.28
Category members GO Category GO:0008201 heparin binding Database 0.27
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0016023 cytoplasmic membrane-bounded vesicle Database 0.17
Category members Disease phenotype Giant_cell_glioblastoma Giant cell glioblastoma Database 0.14
Category members Disease phenotype Gliosarcoma Gliosarcoma Database 0.14
Category members GO Category GO:0002062 chondrocyte differentiation Database 0.13
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Database 0.11
Category members Disease phenotype PILOCYTIC_ASTROCYTOMA_SOMATIC PILOCYTIC ASTROCYTOMA SOMATIC Database 0.09
Category members GO Category GO:0048339 paraxial mesoderm development Database 0.09
Category members GO Category GO:0060045 positive regulation of cardiac muscle cell proliferation Database 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Disease phenotype Septo-optic_dysplasia Septo-optic dysplasia Database 0.08
Category members GO Category GO:0043410 positive regulation of MAPK cascade Database 0.06
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0060117 auditory receptor cell development Database 0.06
Category members GO Category GO:0010976 positive regulation of neuron projection development Database 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0045787 positive regulation of cell cycle Database 0.04
Category members GO Category GO:0048699 generation of neurons Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0010518 positive regulation of phospholipase activity Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1010 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 0 0
Category members Pathway Pathway_1085 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION 0 0
Category members Pathway Pathway_1086 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 0 0
Category members Pathway Pathway_1088 REACTOME_SHC_MEDIATED_CASCADE 0 0
Category members Pathway Pathway_1091 REACTOME_FRS2_MEDIATED_CASCADE 0 0
Category members Pathway Pathway_1092 REACTOME_FGFR_LIGAND_BINDING_AND_ACTIVATION 0 0
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_261 REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_304 REACTOME_PI3K_CASCADE 0 0
Category members Pathway Pathway_598 KEGG_MELANOMA 0 0
Category members Pathway Pathway_657 PID_FGF_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_718 PID_GLYPICAN_1PATHWAY 0 0
Category members Pathway Pathway_783 REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING 0 0
Category members Disease phenotype Idiopathic_hypogonadotropic_hypogonadism_(IHH) Idiopathic hypogonadotropic hypogonadism (IHH) Database 0
Category members Disease phenotype Kallmann_Syndrome Kallmann Syndrome Database 0
Category members Disease phenotype Normosmic_congenital_hypogonadotropic_hypogonadism Normosmic congenital hypogonadotropic hypogonadism Database 0
Category members Disease phenotype Oligodontia Oligodontia Database 0
Category members Disease phenotype PFEIFFER_SYNDROME PFEIFFER SYNDROME Database 0
Category members Disease phenotype Pfeiffer_syndrome_type_1 Pfeiffer syndrome type 1 Database 0
Category members GO Category GO:0000165 MAPK cascade Database 0
Category members GO Category GO:0001501 skeletal system development Database 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001657 ureteric bud development Database 0
Category members GO Category GO:0001759 organ induction Database 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0002053 positive regulation of mesenchymal cell proliferation Database 0
Category members GO Category GO:0005007 fibroblast growth factor-activated receptor activity Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0007435 salivary gland morphogenesis Database 0
Category members GO Category GO:0007605 sensory perception of sound Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0010863 positive regulation of phospholipase C activity Database 0
Category members GO Category GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0017134 fibroblast growth factor binding Database 0
Category members GO Category GO:0018108 peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0021769 orbitofrontal cortex development Database 0
Category members GO Category GO:0021847 ventricular zone neuroblast division Database 0
Category members GO Category GO:0030326 embryonic limb morphogenesis Database 0
Category members GO Category GO:0030901 midbrain development Database 0
Category members GO Category GO:0035607 fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development Database 0
Category members GO Category GO:0042472 inner ear morphogenesis Database 0
Category members GO Category GO:0042473 outer ear morphogenesis Database 0
Category members GO Category GO:0042474 middle ear morphogenesis Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043009 chordate embryonic development Database 0
Category members GO Category GO:0043406 positive regulation of MAP kinase activity Database 0
Category members GO Category GO:0045595 regulation of cell differentiation Database 0
Category members GO Category GO:0045666 positive regulation of neuron differentiation Database 0
Category members GO Category GO:0048378 regulation of lateral mesodermal cell fate specification Database 0
Category members GO Category GO:0048469 cell maturation Database 0
Category members GO Category GO:0048514 blood vessel morphogenesis Database 0
Category members GO Category GO:0048705 skeletal system morphogenesis Database 0
Category members GO Category GO:0048762 mesenchymal cell differentiation Database 0
Category members GO Category GO:0060173 limb development Database 0
Category members GO Category GO:0060445 branching involved in salivary gland morphogenesis Database 0
Category members GO Category GO:0060484 lung-associated mesenchyme development Database 0


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