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Query: LRRK2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LRRK2 0 -0.240 0.530 -0.620 -0.240

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for LRRK2:


Pubmed-LRRK2 »
Uniprot-LRRK2 »
Biogrid-LRRK2 »
ProteomicsDB-LRRK2 »

Tumorportal-LRRK2 »
COSMIC-LRRK2 »
GenomeRNAi-LRRK2 »
Genecards-LRRK2


Protein-protein Interactions for LRRK2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait LRRK2 Cat. description Hein, Mann, Cell 2015


Protein Domains in LRRK2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members P-loop_NTPase IPR027417 2.83
Category members WD40_repeat_dom IPR017986 1.39
Category members Small_GTPase_ARF/SAR IPR006689 0.8
Category members Small_GTPase IPR001806 0.65
Category members Leu-rich_rpt_typical-subtyp IPR003591 0.57
Category members Small_GTPase_Rab_type IPR003579 0.51
Category members MIRO-like IPR013684 0.4
Category members Small_GTP-bd_dom IPR005225 0.32
Category members Leu-rich_rpt IPR001611 0.32
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0
Category members Ankyrin_rpt-contain_dom IPR020683 0


Protein complexes (CORUM database) featuring LRRK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5849 HSP90-CDC37-LRRK2 complex Database 0.08
Category members Corum 5980 LRRK2-CHIP-HSP90 complex Database 0
Category members Corum 5991 LRRK2-FADD-CASP8 Database 0


Categories featuring LRRK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0015631 tubulin binding Database 0.83
Category members GO Category GO:0010942 positive regulation of cell death Database 0.82
Category members GO Category GO:0017048 Rho GTPase binding Database 0.69
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members GO Category GO:0008021 synaptic vesicle Database 0.28
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process Database 0.24
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members GO Category GO:0043547 positive regulation of GTPase activity Database 0.21
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0005096 GTPase activator activity Database 0.19
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0000186 activation of MAPKK activity Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0005802 trans-Golgi network Database 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0021772 olfactory bulb development Database 0.06
Category members GO Category GO:0045202 synapse Database 0.06
Category members GO Category GO:0008340 determination of adult lifespan Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0048312 intracellular distribution of mitochondria Database 0.04
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members GO Category GO:0018107 peptidyl-threonine phosphorylation Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0042391 regulation of membrane potential Database 0
Category members Pathway Pathway_31 KEGG_PARKINSONS_DISEASE 0 0
Category members Disease phenotype PARKINSON_DISEASE_LATE-ONSET PARKINSON DISEASE LATE-ONSET Database 0
Category members Disease phenotype Young_adult-onset_Parkinsonism Young adult-onset Parkinsonism Database 0
Category members GO Category GO:0000165 MAPK cascade Database 0
Category members GO Category GO:0000187 activation of MAPK activity Database 0
Category members GO Category GO:0004708 MAP kinase kinase activity Database 0
Category members GO Category GO:0006914 autophagy Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0007406 negative regulation of neuroblast proliferation Database 0
Category members GO Category GO:0007528 neuromuscular junction development Database 0
Category members GO Category GO:0010508 positive regulation of autophagy Database 0
Category members GO Category GO:0014043 negative regulation of neuron maturation Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0022028 tangential migration from the subventricular zone to the olfactory bulb Database 0
Category members GO Category GO:0031398 positive regulation of protein ubiquitination Database 0
Category members GO Category GO:0032839 dendrite cytoplasm Database 0
Category members GO Category GO:0034260 negative regulation of GTPase activity Database 0
Category members GO Category GO:0035640 exploration behavior Database 0
Category members GO Category GO:0040012 regulation of locomotion Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0043068 positive regulation of programmed cell death Database 0
Category members GO Category GO:0060161 positive regulation of dopamine receptor signaling pathway Database 0
Category members GO Category GO:0061002 negative regulation of dendritic spine morphogenesis Database 0
Category members GO Category GO:0070997 neuron death Database 0
Category members GO Category GO:0071407 cellular response to organic cyclic compound Database 0


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