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Query: MAP3K3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MAP3K3 0 0.029 0.830 -0.050

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MAP3K3 Phosphorylation S175 0.120 -0.091 _S(ph)SPPPGYVPER_
MAP3K3 Phosphorylation S176 0.120 -0.091 _S(ph)SPPPGYVPER_
MAP3K3 Phosphorylation S166 -0.325 _HLS(ph)VSSQNPGR_
MAP3K3 Phosphorylation S250 -0.070 _AQS(ph)FPDNR_

Background Information for MAP3K3:


Pubmed-MAP3K3 »
Uniprot-MAP3K3 »
Biogrid-MAP3K3 »
ProteomicsDB-MAP3K3 »

Tumorportal-MAP3K3 »
COSMIC-MAP3K3 »
GenomeRNAi-MAP3K3 »
Genecards-MAP3K3


Protein-protein Interactions for MAP3K3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANAPC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP85 Cat. description Hein, Mann, Cell 2015
Category members IP bait IP6K3 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIFC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAP3K2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAP2K5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MAP3K3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members OPR_PB1 IPR000270 0
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring MAP3K3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5199 Kinase maturation complex 1 Database 3.38


Categories featuring MAP3K3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members Pathway Pathway_975 REACTOME_IL1_SIGNALING 0 0.42
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0000186 activation of MAPKK activity Database 0.16
Category members GO Category GO:0004709 MAP kinase kinase kinase activity Database 0.08
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1021 ST_TUMOR_NECROSIS_FACTOR_PATHWAY 0 0
Category members Pathway Pathway_1039 PID_P38_ALPHA_BETA_PATHWAY 0 0
Category members Pathway Pathway_1098 PID_P38_MKK3_6PATHWAY 0 0
Category members Pathway Pathway_21 ST_JNK_MAPK_PATHWAY 0 0
Category members Pathway Pathway_257 KEGG_GNRH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_631 PID_IL1_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members GO Category GO:0000165 MAPK cascade Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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