bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: TIMP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TIMP1 0 0.704 0.660 -0.830

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TIMP1 Ubiquitylation K70 1.253 -0.548 _MYK(gl)GFQALGDAADIR_

Background Information for TIMP1:


Pubmed-TIMP1 »
Uniprot-TIMP1 »
Biogrid-TIMP1 »
ProteomicsDB-TIMP1 »

Tumorportal-TIMP1 »
COSMIC-TIMP1 »
GenomeRNAi-TIMP1 »
Genecards-TIMP1


Protein-protein Interactions for TIMP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FGFR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IGFBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MMP10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MMP9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TIMP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Netrin_domain IPR001134 0
Category members Prot_inh_TIMP IPR001820 0
Category members TIMP-like_OB-fold IPR008993 0


Protein complexes (CORUM database) featuring TIMP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2709 MMP-9-TIMP-1-LRP complex Database 0.04


Categories featuring TIMP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0005578 proteinaceous extracellular matrix Database 0.53
Category members GO Category GO:0031012 extracellular matrix Database 0.45
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members GO Category GO:0022617 extracellular matrix disassembly Database 0.13
Category members GO Category GO:0008191 metalloendopeptidase inhibitor activity Database 0.11
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_415 REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION 0 0.09
Category members GO Category GO:0051045 negative regulation of membrane protein ectodomain proteolysis Database 0.04
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_652 PID_IL6_7_PATHWAY 0 0
Category members Pathway Pathway_928 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX 0 0
Category members GO Category GO:0001775 cell activation Database 0
Category members GO Category GO:0002020 protease binding Database 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0005604 basement membrane Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0031093 platelet alpha granule lumen Database 0
Category members GO Category GO:0034097 response to cytokine Database 0
Category members GO Category GO:0042060 wound healing Database 0
Category members GO Category GO:0043249 erythrocyte maturation Database 0
Category members GO Category GO:0043434 response to peptide hormone Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


.

© Copyright Svejstrup Laboratory 2015